DmeALTD0004969-1/3 @ dm6
Alternative 5'ss
Gene
FBgn0010225 | Gel
Description
The gene Gelsolin is referred to in FlyBase by the symbol DmelGel (CG1106, FBgn0010225). It is a protein_coding_gene from Dmel. It has 8 annotated transcripts and 8 polypeptides (3 unique). Gene sequence location is 3R:4235217..4241057. Its molecular function is described by: phosphatidylinositol-4,5-bisphosphate binding; protein binding; actin filament binding. It is involved in the biological process described with: barbed-end actin filament capping; actin filament polymerization; actin filament severing; actin polymerization or depolymerization. 7 alleles are reported. The phenotypes of these alleles manifest in: adult brain; mitochondrion. The phenotypic classes of alleles include: partially lethal - majority die; some die during pupal stage; viable; size defective; partially lethal. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed at stages throughout the larval period, during early pupal stages.
Coordinates
chr3R:4236788-4237817:+
Coord C1 exon
chr3R:4236788-4236804
Coord A exon
NA
Coord C2 exon
chr3R:4237625-4237817
Length
0 bp
Sequences
Splice sites
5' ss Seq
CAGGTAATG
5' ss Score
9.43
3' ss Seq
TTTTTGCTTGTCTCTTTCAGCCT
3' ss Score
9.95
Exon sequences
Seq C1 exon
ATGGCAGTCCTCTCCAG
Seq A exon
NA
Seq C2 exon
CCTGCTTGTGTTTTTGGCCCTCTCGTCCAGTCTGTGCTCAGCCGGCACCCTCAACGCCCGTCCTGCGTTTCCCGTACAATCCGGCGAAATTCAGCCCAGCGGCCAGAACAGCAAGCAGGCAGCCAGACGCGTGATGCATCCTTCCTTCGCCAACGCCGGCCGTACTCCCGGCCTGGAAATCTGGCGCATCGAG
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0010225-3-7,4-7,5-7-1/3
Average complexity
Alt5
Mappability confidence:
NA
Protein Impact
Protein isoform when splice site is used (No Ref)
No structure available
Features
Disorder rate (Iupred):
C1=0.000 A=NA C2=0.307
Domain overlap (PFAM):
C1:
NO
A:
NA
C2:
NO
Main Inclusion Isoform:
FBpp0078607
Main Skipping Isoform:
NA
Other Inclusion Isoforms:
FBpp0078608, FBpp0078612, FBpp0301195
Other Skipping Isoforms:
NA
Associated events
Conservation
Human
(hg38)
No conservation detected
Human
(hg19)
No conservation detected
Mouse
(mm10)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
No suggested primer sequences
R:
No suggested primer sequences
Band lengths:
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)