DmeEX0005780 @ dm6
Exon Skipping
Gene
FBgn0020621 | Pkn
Description
The gene Protein kinase N is referred to in FlyBase by the symbol DmelPkn (CG2049, FBgn0020621). It is a protein_coding_gene from Dmel. It has 17 annotated transcripts and 17 polypeptides (14 unique). Gene sequence location is 2R:9252310..9285097. Its molecular function is described by: protein serine/threonine kinase activity; protein kinase activity; ATP binding; protein binding; GTP-Rho binding. It is involved in the biological process described with 9 unique terms, many of which group under: cellular component organization; regulation of wound healing; localization; cell division; post-embryonic animal organ development. 65 alleles are reported. The phenotypes of these alleles manifest in: cellular anatomical entity; array of sensillum rows; non-connected developing system; adult head; intracellular non-membrane-bounded organelle. The phenotypic classes of alleles include: female semi-sterile; some die during larval stage; increased mortality; phenotype. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period, in adult female stages.
Coordinates
chr2R:9255089-9260144:-
Coord C1 exon
chr2R:9258840-9260144
Coord A exon
chr2R:9255829-9256038
Coord C2 exon
chr2R:9255089-9255709
Length
210 bp
Sequences
Splice sites
3' ss Seq
GAAGAACCATCCTCTTGCAGGCC
3' ss Score
6.19
5' ss Seq
CAGGTAATC
5' ss Score
6.99
Exon sequences
Seq C1 exon
GCCTGCTTAAGCGGAATGCTCCTAACCATGTGCACATGGGATCGGCAGGATCAGGATCTTCTCTAACCGGTAGCTCGCCTATGGTGGTTGGTGGGTCTCGCGACTCTGAGTCTCCGATTTCGAGGACTCCCTCATCCGACGCACTGGTGGAACCGGAGCCCTACACGCCCGGAGAGCAGGCACAGAACTTGGAATTCGATCCCGATGCAGGAATTAATGAACACGTGGAGACGCCAGGTGAATACCCGGATCCGGCGGCCAGTGGTCTGAGCGGAATGCGACCCCTGTCCATGCACATGCAGGGAATTAGTGTGCTGCCCCCGGAATCGCCACCCGTGGCCACCGGAGCAGCTGGTCGGCCCAATACGCTCAGCTTACAGATGCCGGGTGCCAGTAAAGGACAGGTGATCCAAGGCGGACGGACTGCGGCGCCTACAACGGCGCCACCGCCACCACCTGTGCTCAAGGCGACATCCACCACTCCGATATTGGATCAGGAG
Seq A exon
GCCCGTATTAGTCTTGTACATATAACCCTCGAACCGATCAATGCCAGCCGGACGACCAGTTGCCTGATCGAGGAGGTAGCCGAGCCGGATTCACAGCCGGAGATTAAGCCGGTGGCAGAAGCGCAGTCTGCCAAAGTATCCGAGGCTTGTGTCGAAAGTATTCTCCCCGAGACAGTTGAAAAGTTAGAAACAGCAGACCAGGTCCAGCAG
Seq C2 exon
GTTATACCACAGTTGGGGAAGCTTTACGTGGGCAGTAGCCAGCAGCAGTATGCGCAGCAGTCATCGCCCATCATCCAGGAGCCAGCTACTCCTACTATTTACGGAAACAGCGCCGCAGCCGGAGCGCCGCAGTTCCCGCAGCCCGCCCAAAGGCAAGAGAAGCAGCCTCCGCAGCAGCAGCCCATCTACGCTAACCAGTATGAGCTGAATGTGGCCAAGGCGGCAGCTGCAGCATCTGTTTACTCACCCAGCTCCTCCACCACCAGCAACTCCAATCAACAGCAGCAGCAGCAGCGCCGGAATGTGGCCCGTGGACTGCAGTATCGTGAATCTGGAGGACTCGAGACTGGACGTGCTGGCAAGCAGCCACCCAATGCGGGCATGTTGTCAATGGACAACTTCCGTTTGCTAAGCGTTCTTGGTCGCGGCCACTTTGGCAAGGTGATTCTGTCCCAATTGCGAAGCAACAACCAGTACTACGCTATTAAGGCACTGAAGAA
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0020621_MULTIEX1-2/2=C1-C2
Average complexity
C2
Mappability confidence:
100%=100=100%
Protein Impact
Alternative protein isoforms (No Ref)
No structure available
Features
Disorder rate (Iupred):
C1=0.461 A=0.459 C2=0.480
Domain overlap (PFAM):
C1:
PF154561=Uds1=PD(36.8=6.4),PF0218511=HR1=PD(43.2=7.4)
A:
NO
C2:
PF0006920=Pkinase=PU(28.1=35.3)
Main Inclusion Isoform:
FBpp0291760

Main Skipping Isoform:
FBpp0290726

Other Inclusion Isoforms:
FBpp0087686, FBpp0291759, FBpp0297540, FBpp0300526, FBpp0308399, FBpp0308403
Other Skipping Isoforms:
FBpp0087682, FBpp0087683, FBpp0087684, FBpp0087685, FBpp0111810, FBpp0308400, FBpp0308401, FBpp0308402
Associated events
Conservation
Human
(hg38)
No conservation detected
Human
(hg19)
No conservation detected
Mouse
(mm10)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
TGCAGGGAATTAGTGTGCTGC
R:
GAGTAGCTGGCTCCTGGATGA
Band lengths:
294-504
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)