Special

FBgn0020621 @ dm6

Biotype
protein_coding
Gene Symbol
Pkn
Description
The gene Protein kinase N is referred to in FlyBase by the symbol DmelPkn (CG2049, FBgn0020621). It is a protein_coding_gene from Dmel. It has 17 annotated transcripts and 17 polypeptides (14 unique). Gene sequence location is 2R:9252310..9285097. Its molecular function is described by: protein serine/threonine kinase activity; protein kinase activity; ATP binding; protein binding; GTP-Rho binding. It is involved in the biological process described with 9 unique terms, many of which group under: cellular component organization; regulation of wound healing; localization; cell division; post-embryonic animal organ development. 65 alleles are reported. The phenotypes of these alleles manifest in: cellular anatomical entity; array of sensillum rows; non-connected developing system; adult head; intracellular non-membrane-bounded organelle. The phenotypic classes of alleles include: female semi-sterile; some die during larval stage; increased mortality; phenotype. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period, in adult female stages.
Coordinates
chr2R:9252310-9285097:-
Assembly

GENOMIC BROWSER[edit]


EXPRESSION VALUES[edit]


SPECIAL DATASETS

  • Neural diversity
  • Neurogenesis
  • Neuronal activity
  • Splicing factor regulation (brain)
  • Splicing factor regulation (SL2)

EVENTS AND AS PROFILES[edit]

Associated events[edit]

Event
Type
Length
Coordinates
Strand
PSI Average
PSI Range
Annotated Functions
Alternative 3'ss
0
NA
-
20.9
30.63
0
Alternative 3'ss
6
chr2R:9257674-9257679
-
36.94
60.78
0
Alternative 3'ss
387
chr2R:9257674-9258060
-
41.36
79.72
0
Alternative 5'ss
101
chr2R:9284959-9285059
-
89.56
73.58
0
Exon Skipping
408
chr2R:9272300-9272707
-
5.35
24.73
0
Exon Skipping
651
chr2R:9257410-9258060
-
23.5
93.86
0
Exon Skipping
210
chr2R:9255829-9256038
-
21.52
76.47
0
Exon Skipping
190
chr2R:9271985-9272174
-
18.05
84.71
0
Exon Skipping
410
chr2R:9268369-9268778
-
5.61
45.45
0
Intron Retention
15851
chr2R:9267977-9283827
-
3.48
70.04
0



Orthologous genes[edit]

Organism Assembly Gene ID Gene Name Orthology Type

Human hg38 ENSG00000065243 PKN2 1-to-3
Human hg38 ENSG00000123143 PKN1 1-to-3
Human hg38 ENSG00000160447 PKN3 1-to-3
Human hg19 ENSG00000065243 PKN2 1-to-3
Human hg19 ENSG00000123143 PKN1 1-to-3
Human hg19 ENSG00000160447 PKN3 1-to-3
Mouse mm10 ENSMUSG00000004591 Pkn2 1-to-3
Mouse mm10 ENSMUSG00000026785 Pkn3 1-to-3
Mouse mm10 ENSMUSG00000057672 Pkn1 1-to-3
Mouse mm9 ENSMUSG00000004591 Pkn2 1-to-3
Mouse mm9 ENSMUSG00000026785 Pkn3 1-to-3
Mouse mm9 ENSMUSG00000057672 Pkn1 1-to-3
Rat rn6 ENSRNOG00000004131 Pkn1 1-to-3
Rat rn6 ENSRNOG00000011317 Pkn2 1-to-3
Rat rn6 ENSRNOG00000025892 Set 1-to-3
Cow bosTau6 ENSBTAG00000010195 PKN3 1-to-3
Cow bosTau6 ENSBTAG00000017037 PKN1 1-to-3
Cow bosTau6 ENSBTAG00000021900 PKN2 1-to-3
Chicken galGal4 ENSGALG00000004689 PKN3 1-to-2
Chicken galGal4 ENSGALG00000006237 PKN2 1-to-2
Chicken galGal3 ENSGALG00000004689 PKN3 1-to-2
Chicken galGal3 ENSGALG00000006237 1-to-2
Zebrafish danRer10 ENSDARG00000060184 pkn1a 1-to-5
Zebrafish danRer10 ENSDARG00000062748 pkn1b 1-to-5
Zebrafish danRer10 ENSDARG00000079585 pkn3 1-to-5
Zebrafish danRer10 ENSDARG00000101293 PKN2 (1 of 2) 1-to-5
Zebrafish danRer10 ENSDARG00000101983 pkn2 1-to-5