DmeEX0007849 @ dm6
Exon Skipping
Gene
FBgn0000535 | eag
Description
The gene ether a go-go is referred to in FlyBase by the symbol Dmeleag (CG10952, FBgn0000535). It is a protein_coding_gene from Dmel. It has 8 annotated transcripts and 8 polypeptides (7 unique). Gene sequence location is X:14955477..15009989. Its molecular function is described by: voltage-gated cation channel activity; voltage-gated potassium channel activity; ion channel binding. It is involved in the biological process described with 11 unique terms, many of which group under: cognition; behavior; multicellular organismal process; learning or memory; transport. 31 alleles are reported. The phenotypes of these alleles manifest in: cytoplasm; organelle; nervous system; myofibril; cellular anatomical entity. The phenotypic classes of alleles include: mating defective; phenotype; sensory perception defective; behavior defective. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of extremely low expression. Peak expression observed during late larval stages, during early pupal stages.
Coordinates
chrX:15000413-15009989:+
Coord C1 exon
chrX:15000413-15000828
Coord A exon
chrX:15002112-15002402
Coord C2 exon
chrX:15004035-15009989
Length
291 bp
Sequences
Splice sites
3' ss Seq
AATGCAACAACATATACAAGAAG
3' ss Score
-6.07
5' ss Seq
AAAGTAATT
5' ss Score
3.64
Exon sequences
Seq C1 exon
GCAAGGGCGACGTCTTCGGCGATCAATTCTGGAAGGACTCGGCCGTTGGCCAGAGTGCGGCCAATGTGCGTGCTCTGACCTATTGTGATTTGCATGCCATCAAACGTGATAAATTGCTCGAAGTCCTCGATTTCTATTCGGCATTTGCGAATAGCTTTGCACGCAATCTGGTGCTCACCTACAATCTCAGACATCGACTGATTTTTCGCAAGGTGGCCGATGTGAAGCGCGAAAAAGAATTGGCCGAACGGCGTAAGAACGAGCCGCAATTGCCCCAGAATCAGGACCATCTCGTCCGGAAGATCTTCTCCAAATTTCGTCGCACTCCGCAGGTCCAAGCGGGCAGTAAGGAGCTCGTCGGCGGTTCCGGCCAAAGTGATGTCGAGAAGGGTGACGGCGAGGTGGAGCGAACTAAG
Seq A exon
AAGCTACCAGCCAAACTGACACTGACCGAGGACGCTCGCATCCTTAGCACCGCCGCGGCGCCCTCGCCATCGCCATCCCCATCGCCCTCATCGGGTCCACCATCTGCGCGCAGTACACGGGCCAGCAAGTGGGGACGCCTCCTGGGCAGTTCAAGCGTCGATTCAGCTAGCGACACCAGCGCCAAGGTAGCCGTCTCGAGAAGTTTGAGCGCCCGCGAAAGCCTCCGAGAGAGCACCGCCCAAGCGCGGCAGAGTAGTACTTCGAGTAGCAATGGTGGACAAGGCAACAAA
Seq C2 exon
GTTTTTCCCAAGGCGCCCAAGCTGCAAGCTAGCCAGGCCACCCTTGCCCGCCAGGACACCATCGACGAGGGTGGCGAGGTGGACTCCTCGCCGCCAAGTCGCGACAGTCGCGTGGTCATCGAGGGTGCAGCCGTCTCCTCGGCCACCGTGGGACCATCGCCGCCAGTGGCTACCACATCCTCGGCGGCGGCGGGAGCTGGAGTATCTGGAGGACCAGGAAGTGGAGGCACTGTTGTGGCCATTGTCACCAAAGCGGATCGCAATCTGGCCTTGGAGCGAGAGCGACAAATCGAAATGGCCAGCTCGAGGGCCACCACATCGGATACGTACGATACCGGGCTGCGCGAGACGCCGCCCACGCTGGCGCAGCGCGATCTCATCGCCACCGTGCTGGACATGAAGGTGGATGTGCGGCTGGAGCTGCAGCGCATGCAGCAGCGGATTGGCCGCATTGAGGATCTGCTGGGCGAGCTGGTCAAGCGGCTGGCACCCGGTGCCGG
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0000535_MULTIEX1-1/2=C1-C2
Average complexity
C2*
Mappability confidence:
100%=100=100%
Protein Impact
Alternative protein isoforms (No Ref)
No structure available
Features
Disorder rate (Iupred):
C1=0.308 A=0.956 C2=0.905
Domain overlap (PFAM):
C1:
PF0002724=cNMP_binding=PD(54.7=33.8)
A:
NO
C2:
NO
Main Inclusion Isoform:
FBpp0301719
Main Skipping Isoform:
FBpp0073772
Other Inclusion Isoforms:
FBpp0110308, FBpp0292378
Other Skipping Isoforms:
NA
Associated events
Conservation
Human
(hg38)
No conservation detected
Human
(hg19)
No conservation detected
Mouse
(mm10)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
CGGCCAAAGTGATGTCGAGAA
R:
TGGTGACAATGGCCACAACAG
Band lengths:
299-590
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)