DmeEX6009750 @ dm6
Exon Skipping
Gene
FBgn0261698 | CG42732
Description
The gene slowpoke 2 is referred to in FlyBase by the symbol DmelSLO2 (CG42732, FBgn0261698). It is a protein_coding_gene from Dmel. It has 10 annotated transcripts and 10 polypeptides (9 unique). Gene sequence location is 2R:10322195..10416996. Its molecular function is described by: calcium-activated potassium channel activity; outward rectifier potassium channel activity; intracellular sodium activated potassium channel activity. It is involved in the biological process described with: potassium ion transmembrane transport; potassium ion transport. 21 alleles are reported. The phenotypes of these alleles manifest in: mesothoracic tergum; ganglion mother cell; trichogen cell. The phenotypic classes of alleles include: phenotype; increased mortality; increased mortality during development; some die during P-stage.
Coordinates
chr2R:10340123-10412896:-
Coord C1 exon
chr2R:10412236-10412896
Coord A exon
chr2R:10388134-10388735
Coord C2 exon
chr2R:10340123-10340202
Length
602 bp
Sequences
Splice sites
3' ss Seq
CATTTATCAATGTCACTTAGTTG
3' ss Score
2.59
5' ss Seq
AAGGTGAGT
5' ss Score
10.47
Exon sequences
Seq C1 exon
GGTAAGGGGCATTGTTCGACCAGAAGGACACTCGCCAATCTGTGGACGCGCCTACGCTCGCCGCGGCCCAATCGGGCCACTGGCGGCTATCTGCTGACGGGCACAAGTGCGCCGCGTGACGATGAGTTCGTCGCAGGACGGAGGCATCTTCTGGATCAGGGCAAGGATAAGGATAAGGAGCAGCAGCAGCTGGGGCGGCGGGCATACGCACCTGCCGATGAGTGCTTAATTAATGTGACGGACTTTAGTGATATACAAATAAGTGAGGGGACTGGCGAGGCAGTGGCCAAGACCATCACCGAGCTGAGAGTGCCCACCATAACGACCACAAACAACAGCACCACCATCCACAGCAACAGCAACAGCAACAGCAACAGCAACAGCAACAGCAGCAACATCAACAGCAACAACAATAGCAACATGTCGCGCCTTATACAACCGCGATATCGTTTTCGGGATCTATTACTGGGCGATTTCTCATTTAACGACGACGGCGAAAG
Seq A exon
TTGCAGAATATAGCGATGTGGCTAAAGACGAGAGCGGGATCGAACGACGGAGAGAGACAGCCAATTGTTTGGGCTGATTGTGCTTAATGAAGTGTCGGATATGTCATGAGCCCAGACAATAAACAAGCCTTCGCAGTCCGCAGACCGTGCTCGGTGCAGATGCATCTGTGAGATACAAAACATGACCGGGAAATGTGAAAAGTAAGCAGTGACAACGAGCCGCGAGTGTGAGAACACAGCTAAATTATGTAGACCTGGTCAGAACCGGTGACCTGGTCAGAATCGTACACATATCCCGAATCGCCTCCCGTGCCGAAGGACATGAGCCAAAACCTCCAAGTGAGCTACACCGCTTTGGCCATGTCGGACGATAATCAAACCTGCAGCTACTCGATGCCCTCGGTGGCGTCGCCCAGCCTCAATCACCGCCTGCAGCGCAATGTCAACTTCAACGAGGACCTCAACGACCTGGCCGGCTACCCCCCGCAGCAGCTGCCCACCGCCCCGGCGGTCCGCCGCTTCTCCAAGTCCATTTTCCAGCGACCGCGTTCCATGTCCGTTTGGAGTGACATCAGTCGCAGCAGTATGCGTCTGGATGAAAG
Seq C2 exon
AGTTCGGGTGGAGTACTATGTGAACGAAAACACATTCAAAGAAAGACTGCAACTCTATTTCATTAAGAATCAGCGTTCAA
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0261698-'2-15,'2-4,4-15=AN
Average complexity
A_C2
Mappability confidence:
100%=100=100%
Protein Impact
Alternative protein isoforms (Ref, Alt. ATG (>10 exons))
No structure available
Features
Disorder rate (Iupred):
C1=0.000 A=0.031 C2=0.000
Domain overlap (PFAM):
C1:
NO
A:
NO
C2:
NO
Main Inclusion Isoform:
FBpp0292199
Main Skipping Isoform:
FBpp0302905
Other Inclusion Isoforms:
FBpp0292200
Other Skipping Isoforms:
FBpp0292202, FBpp0297088, FBpp0303466
Associated events
Conservation
Human
(hg38)
No conservation detected
Human
(hg19)
No conservation detected
Mouse
(mm10)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
AAGGATAAGGAGCAGCAGCAG
R:
CGTTCACATAGTACTCCACCCG
Band lengths:
358-960
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)