HsaEX0073614 @ hg38
Exon Skipping
Gene
ENSG00000170954 | ZNF415
Description
zinc finger protein 415 [Source:HGNC Symbol;Acc:HGNC:20636]
Coordinates
chr19:53107879-53122743:-
Coord C1 exon
chr19:53122662-53122743
Coord A exon
chr19:53116313-53116433
Coord C2 exon
chr19:53107879-53109908
Length
121 bp
Sequences
Splice sites
3' ss Seq
GTTTATTATTTTACGGACAGTTG
3' ss Score
4.94
5' ss Seq
TGGGTGAGG
5' ss Score
6.74
Exon sequences
Seq C1 exon
CATTGACTTCCAAAGACTCCTGGCACATGAGGAAGAAACCCAGAAGAGGAGAGCAAAGGAGTCAGGAATGGCTTTTACTCAG
Seq A exon
TTGACATTCAGGGACGTGGCCATCGAATTCTCTCAAGATGAGTGGAAATGCCTGAACTCTACACAGAGGACTTTATACAGGGATGTGATGTTGGAGAACTACAGGAACCTGGTCTCCCTGG
Seq C2 exon
ATCTGTCTCGTAACTGTGTAATCAAGGAACTAGCACCACAACAGGAAGGTAACCCAGGAGAAGTATTCCACACAGTGACATTGGAACAACATGAAAAACATGACATTGAAGAGTTTTGCTTCAGGGAAATCAAGAAAAAAATACACGACTTTGACTGTCAGTGGAGAGATGATGAAAGAAATTGCAACAAAGTGACTACGGCCCCAAAAGAAAATCTTACTTGTAGGAGAGACCAACGCGATAGAAGAGGTATAGGAAACAAGTCTATTAAACATCAGCTTGGATTAAGCTTTCTACCACATCCCCATGAACTGCAGCAGTTTCAAGCTGAAGGGAAAATTTATGAATGTAACCATGTTGAGAAGTCTGTCAACCATGGTTCCTCAGTTTCACCACCCCAAATAATTTCTTCTACCATCAAAACCCATGTTTCTAATAAATATGGGACTGATTTCATCTGTTCTTCATTACTCACACAAGAACAGAAATCATGCATTAGG
VastDB Features
Vast-tools module Information
Secondary ID
ENSG00000170954-'7-34,'7-12,11-34
Average complexity
C2
Mappability confidence:
96%=100=91%
Protein Impact
ORF disruption upon sequence exclusion
No structure available
Features
Disorder rate (Iupred):
C1=0.228 A=0.000 C2=0.097
Domain overlap (PFAM):
C1:
NO
A:
PF0135222=KRAB=WD(100=100.0)
C2:
PF0135222=KRAB=PD(0.1=0.0),PF134651=zf-H2C2_2=WD(100=5.3),PF134651=zf-H2C2_2=WD(100=5.1),PF134651=zf-H2C2_2=WD(100=4.9),PF134651=zf-H2C2_2=WD(100=4.9),PF134651=zf-H2C2_2=WD(100=5.1),PF134651=zf-H2C2_2=WD(100=5.1),PF134651=zf-H2C2_2=WD(100=5.1),PF0013017=C1_1=WD(100=10.6),PF134651=zf-H2C2_2=WD(100=5.1),PF134651=zf-H2C2_2=WD(100=5.1),PF134651=zf-H2C2_2=WD(100=5.1),PF0013017=C1_1=WD(100=10.0),PF134651=zf-H2C2_2=WD(100=5.1)
Other Inclusion Isoforms:
Other Skipping Isoforms:
NA
Associated events
Other assemblies
Conservation
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
AGCAAAGGAGTCAGGAATGGC
R:
TCTTTTGGGGCCGTAGTCACT
Band lengths:
242-363
Functional annotations
There are 1 annotated functions for this event
PMID: 17055453
Isoforms 2-5 are cytoplasmic, isoform 1 is nuclear. Isoforms 2-5, but not 1, inhibit AP-1 and p53. Isoforms are all expressed in both adult and fetal tissue. Exon 3 = HsaEX0073614, Exon 4 = HsaEX0073615, ALTA in Exon 4 = HsaALTA0009817, Exon 5 = HsaEX0073616. Isoform 1: skips exons 3, 4 and 5; Isoform 2: skips exon 4; Isoform 3: short version of exon 4; Isoform 4: long form of exon 4 and skipping of exon 5; Isoform 5: skippin of exons 4 and 5.
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- The Cancer Genome Atlas (TCGA)
- Genotype-Tissue Expression Project (GTEx)
- Autistic and control brains
- Pre-implantation embryo development