HsaEX6018383 @ hg38
Exon Skipping
Gene
ENSG00000115414 | FN1
Description
fibronectin 1 [Source:HGNC Symbol;Acc:HGNC:3778]
Coordinates
chr2:215371635-215372300:-
Coord C1 exon
chr2:215372109-215372300
Coord A exon
chr2:215371909-215372015
Coord C2 exon
chr2:215371635-215371735
Length
107 bp
Sequences
Splice sites
3' ss Seq
CAATCCAAATGCCTCTACAGGAC
3' ss Score
5.77
5' ss Seq
CAGGTAATT
5' ss Score
8.55
Exon sequences
Seq C1 exon
TTCAAAAGACCCCTTTCGTCACCCACCCTGGGTATGACACTGGAAATGGTATTCAGCTTCCTGGCACTTCTGGTCAGCAACCCAGTGTTGGGCAACAAATGATCTTTGAGGAACATGGTTTTAGGCGGACCACACCGCCCACAACGGCCACCCCCATAAGGCATAGGCCAAGACCATACCCGCCGAATGTAG
Seq A exon
GACAAGAAGCTCTCTCTCAGACAACCATCTCATGGGCCCCATTCCAGGACACTTCTGAGTACATCATTTCATGTCATCCTGTTGGCACTGATGAAGAACCCTTACAG
Seq C2 exon
TTCAAGACCAGCCTGGCCAACATGGTGAAACCTCGTCTCTTGAAAAAAAAAAAAAAAAAAAAGTGGCTCCACTTTTAGAACCTCTTAGAAGATGGCACATT
VastDB Features
Vast-tools module Information
Secondary ID
ENSG00000115414-'107-123,'107-122,108-123
Average complexity
C3*
Mappability confidence:
100%=100=100%
Protein Impact
ORF disruption upon sequence exclusion
No structure available
Features
Disorder rate (Iupred):
C1=0.988 A=0.636 C2=NA
Domain overlap (PFAM):
C1:
PF0004116=fn3=PU(9.0=10.8)
A:
PF0004116=fn3=PU(47.8=91.7)
C2:
NA
Main Skipping Isoform:
NA
Other Inclusion Isoforms:
Other Skipping Isoforms:
NA
Associated events
Other assemblies
Conservation
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
CACCCTGGGTATGACACTGGA
R:
AGAGGTTCTAAAAGTGGAGCCAC
Band lengths:
254-361
Functional annotations
There are 1 annotated functions for this event
PMID: 11246004
The alternatively spliced IIICS segment possesses the major alpha4beta1 integrin-binding sites. The exon is associated to HsaALTA0003426 and other complex AS events.
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Autistic and control brains