HsaEX6065026 @ hg19
Exon Skipping
Gene
ENSG00000166535 | A2ML1
Description
alpha-2-macroglobulin-like 1 [Source:HGNC Symbol;Acc:23336]
Coordinates
chr12:9020438-9021223:+
Coord C1 exon
chr12:9020438-9020653
Coord A exon
chr12:9020826-9020953
Coord C2 exon
chr12:9021133-9021223
Length
128 bp
Sequences
Splice sites
3' ss Seq
TACCTATTTCTTCCTACCAGACG
3' ss Score
8.41
5' ss Seq
CAGGTGATT
5' ss Score
5.95
Exon sequences
Seq C1 exon
GATACTGTAGTTGCTCTCCAAGCTCTTGCCAAATATGCCACTACCGCCTACATGCCATCTGAGGAGATCAACCTGGTTGTAAAATCCACTGAGAATTTCCAGCGCACATTCAACATACAGTCAGTTAACAGATTGGTATTTCAGCAGGATACCCTGCCCAATGTCCCTGGAATGTACACGTTGGAGGCCTCAGGCCAGGGCTGTGTCTATGTGCAG
Seq A exon
ACGGTGTTGAGATACAATATTCTCCCTCCCACAAATATGAAGACCTTTAGTCTTAGTGTGGAAATAGGAAAAGCTAGATGTGAGCAACCGACTTCACCTCGATCCTTGACTCTCACTATTCACACCAG
Seq C2 exon
TTATGTGGGGAGCCGTAGCTCTTCCAATATGGCTATTGTGGAAGTGAAGATGCTATCTGGGTTCAGTCCCATGGAGGGCACCAATCAGTTA
VastDB Features
Vast-tools module Information
Secondary ID
ENSG00000166535-'31-32,'31-31,32-32=AN
Average complexity
A_S
Mappability confidence:
100%=100=100%
Protein Impact
ORF disruption upon sequence exclusion
No structure available
Features
Disorder rate (Iupred):
C1=0.000 A=0.000 C2=0.000
Domain overlap (PFAM):
C1:
PF076789=A2M_comp=PD(5.3=18.1)
A:
PF079778=FabA=FE(45.2=100)
C2:
PF079778=FabA=PD(22.6=67.7),PF076779=A2M_recep=PU(25.0=71.0)
Main Skipping Isoform:
NA
Other Skipping Isoforms:
NA
Associated events
Other assemblies
Conservation
Rat
(rn6)
No conservation detected
Chicken
(galGal4)
No conservation detected
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
TGCCATCTGAGGAGATCAACCT
R:
AACTGATTGGTGCCCTCCATG
Band lengths:
254-382
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Autistic and control brains
Other AS DBs:
FasterDB (Includes CLIP-seq data)
AS-ALPS (AS-induced ALteration of Protein Structure, links to PINs)
APPRIS (Selection of principal isoform)
DEU primates (Only for human)