HsaEX6070855 @ hg19
Exon Skipping
Gene
ENSG00000100453 | GZMB
Description
granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) [Source:HGNC Symbol;Acc:4709]
Coordinates
chr14:25101530-25103473:-
Coord C1 exon
chr14:25103312-25103473
Coord A exon
chr14:25102121-25102268
Coord C2 exon
chr14:25101530-25101665
Length
148 bp
Sequences
Splice sites
3' ss Seq
CAGACAGACTTTTCCTTCAGGGG
3' ss Score
4.59
5' ss Seq
AAGGTGAGG
5' ss Score
9.16
Exon sequences
Seq C1 exon
GGAACATGAAGTCACTGAGCCTGCTCCACCTCTTTCCTCTCCCAAGAGCTAAAAGAGAGCAAGGAGGAAACAACAGCAGCTCCAACCAGGGCAGCCTTCCTGAGAAGATGCAACCAATCCTGCTTCTGCTGGCCTTCCTCCTGCTGCCCAGGGCAGATGCAG
Seq A exon
GGGAGATCATCGGGGGACATGAGGCCAAGCCCCACTCCCGCCCCTACATGGCTTATCTTATGATCTGGGATCAGAAGTCTCTGAAGAGGTGCGGTGGCTTCCTGATACGAGACGACTTCGTGCTGACAGCTGCTCACTGTTGGGGAAG
Seq C2 exon
CTCCATAAATGTCACCTTGGGGGCCCACAATATCAAAGAACAGGAGCCGACCCAGCAGTTTATCCCTGTGAAAAGACCCATCCCCCATCCAGCCTATAATCCTAAGAACTTCTCCAACGACATCATGCTACTGCAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSG00000100453-'1-1,'1-0,2-1=AN
Average complexity
A_S
Mappability confidence:
100%=100=100%
Protein Impact
ORF disruption upon sequence exclusion
No structure available
Features
Disorder rate (Iupred):
C1=0.149 A=0.045 C2=0.268
Domain overlap (PFAM):
C1:
NO
A:
PF0008921=Trypsin=WD(100=96.0),PF0008921=Trypsin=PU(1.5=4.0)
C2:
PF0008921=Trypsin=FE(20.5=100)
Other Inclusion Isoforms:
Other Skipping Isoforms:
NA
Associated events
Other assemblies
Conservation
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
ACATGAAGTCACTGAGCCTGC
R:
TGGATGGGGGATGGGTCTTTT
Band lengths:
250-398
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Autistic and control brains
Other AS DBs:
FasterDB (Includes CLIP-seq data)
AS-ALPS (AS-induced ALteration of Protein Structure, links to PINs)
APPRIS (Selection of principal isoform)
DEU primates (Only for human)