HsaINT0000084 @ hg38
Intron Retention
Gene
ENSG00000166535 | A2ML1
Description
alpha-2-macroglobulin like 1 [Source:HGNC Symbol;Acc:HGNC:23336]
Coordinates
chr12:8869135-8874527:+
Coord C1 exon
chr12:8869135-8869203
Coord A exon
chr12:8869204-8874424
Coord C2 exon
chr12:8874425-8874527
Length
5221 bp
Sequences
Splice sites
5' ss Seq
GAGGTAGGT
5' ss Score
9.65
3' ss Seq
TTCATCTGTCTTCCCCACAGCTC
3' ss Score
11.91
Exon sequences
Seq C1 exon
CTTCTCCAGCAACCCCTGGTGAAGAAGGTTGAATTTGGAACTGACACACTTAACATTTACTTGGATGAG
Seq A exon
GTAGGTATTCAGGAACCAGATCAAAGAGCTGGATTGCTTACGGATCTTCATGACTTCCCTTCTAATCTGTATATACGGGTGTCACACACATGGGGATGAGGGGCCTGGGAGTGAGTCCACACCATGCCATGAGTTCTGCCTCCATGCTGGTATACCGTAAAACACCCCATTGTGCCTCTAGAGGAGCCCTGTCCAACAGACCTATAATGTGAGCCGTTTACGACATTTGAAGATTTCTGGTAGACACATTTAAAAAGTATAGAAACAGATGAAATTAAGTTTAACGGTATATTTTATGCAAGCTTATACACCCCAAATATTTCCATTTTACCATACAATTAATATACAGACGTATTAATGAGATATCTACATTCTTTTTTTTTTTCTGTACCACATCTTTGAAATCCAGTATGTACTTTACACTGTCAGTGCATCTCAATTCTGACTGACCTCATTTCAAGTGCTCAATAGCCACAAGTGACATTGCAACTCTAGAGTATGTTATAGTGGTTAATAGCAGAAGCTCTGAAGCCAGACTGCCTGGGCTGTGATCTTGGTTCTAGCATTGACTGAGTAACTGGACAAGCTGTTGAAAGTTAGCTGTAAAATGTGTGTGGGTAGGGGTCAAAATAGTTCTTTTAGAGTTATAGAAAAAACTAAATTATTTAAGACATGTAAAAATATTTAGAACTGTACCTGGTATAGAGTAAGCCCTCATCACTTTATAGCTATTCCTATCATTTTAACATAATGTTAATATTACTTAATATTAATCAGACATTGTATGTAACCTTTCATTTTAACAAAACAAGAAGTTCTCAAGGACTAACAATGTTCTAAAGATTGTTACAATGTTCCTTTTCATGATATTCCATTCCACACAAGGAACAAAGTTATCCTTATTGAATATAACCAAAAGACAAGAATATCCCAAATCAAAACATACTGTTGTTAGTAACATCCATTTCCAACCCCCTGCCCACCCACCAACCCCATCATCTAACTGTGTTTCCTGTCTTCCAGGGAGCCAGGGTTTTTTATGTTGTGTGAGCCGTGTATAGTTTCTTTTTTCTTTTTTTTTTGAGACGCAGTCTCGCTCTGTCACCCAGGCTGGAGTGCAGTGGCACAATCTCAGCTCACTGTAAGCTCTGCCTCCCGGGTTCATGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACCACATGCGCCCGCCACCATGCCCGGCTAATTTTTTGTATTTTTACTAGAGACAGGGTTTCACCGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCACCCACCTCGGCCTCCCAAAGTGTTAGGATTACAGGCGTAAGCCACCGCACCCAGCCGAGTTGTGTATAGTTTCTTTTGAGACAGCTCGGGTTAGCTTATCTGGCACTACCCTGTAATCATGATGTTGCTGTTTAAAACTTTGCCAAGTTTATGATGCTTTCATACATGACTTATTCAAGTCTTACAGCCACCCTCCTTAGACATAAGGAGACAGAGTTGGAGAGAGAGAGTGGGTTGTCCAAGTCATACCATCTGTCAGTGTCTAGGGTGGGAGCAGAACCTGGGGAGTCTGATTTCCATGACACCATGCCTGAGACTGCAATGAACTGCTCCTCAGTGTGTCCTGCCAAATCTGCCAGTTGGCTTCTAATTTGAGTTAACAGGCCTAATGATCTAAAAGCCAGTGCTAATCATTGTATCTGTGGTTATTTCCTCTTTTCTGTGTGTCTTCTCCCTTGTGTTCTTGATCAATTTCACCAGAGGATGACCTTATTCACATATATAGTCTTCCTTATTTTTTGATGAACTTACACTATAAGCGTCCCTCTAGGTACATGCCATCCCTCTCCCACAATCTCAGACAAGCAATGTTTTTACTGTCATTCAGTTCTAACTATTTCTTAATTTGTTGGGAAACACATGGAATTTTTAAAGCCATCCTTTTGTTCCTGATGTCTAATTTTGTTGCATTATGGTCTGAGAATACAGTCTTCATGATCCTGATTGCCTGGAATGTGCTGAAGTTTCTTCCATGACCTAATCCATGATCTGTTTTTGCAGGTGTTCAGTGTGCACTCCAAAAGAACATCTATTTCTTTTCTCTTGGGCTTGGATTCTGATCTAGAAGTCTGAGATCATTATTTCTGTTGTTCATGTGTTTGATAACTCTGCTTATTTTTCTGCTTGATTTAACAATTTCTGAAAAGCATGTGTTAAAATATCCAATTATGATGGTTTTTGTTTGTTTGTTTAGTATTTTTTTGGTAGAGACAGCGTTTCACCATGTTGGCCAGGCTGGTCTTGAACTTCTGACCTCAAGTGATCTGCCTGCCTAGGCCTCCCAAAGTGCTGGAGTTATAGGTGTGAGCCACCACGCCTGGCCTCTAATTATGATATTTGATTTATCCATTTATCCATACATTTCTGCCAATTGTTTCCTGATATATTTGAGACTACATAATTAGATATATATGTTATGAACATATCTTCTTATTAAATTTTCCTTATATTAGTACATACTATCCTTTCCCCATTACTATATATGTGTATATATTTATATCATTTACTTTTGCCTTAGATTCTTACACTCCCCCACCGCCACACACACACACACAATTTTTTTCCCTTGCCTTGGGTGCCATTTAGTCAGATATTAAAACTGCTACCTGGCCGGGCGCAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGACGGGCAGATCATGAGGTCAGGAGATCAAGACCATCCTGGCTAACACAGTGAAACCCCGTCTGTACTAAAGGTACAAAAAGTTAGCTGGGCGTGGTGGCAGGAGCCTGTAGTCCCAGCTACTCAGGTGGCTGAGGCACAAGAATGGCGTGAACCTGGGAGGCAGAGCTTGCAGTGAGCCGAGATTGCGCCACTGCACTCCAGCCTGGGCAACGGTGCAAGACTCCATCTCAGAAAAAAGAAAAAAAAAAAAAAACTGCTACCCCAGCTTTCTTTTGGTTCATATTAGTCATTTGCTTTAATTCATTATGGTGACCAAATGATAGAAAAGAACAGTGGTTCTAAAAATTCTTTGTTTCAGTGTCCCTTTATACTCTTAATTTACTGAGGACCTCAAACAGCTTTCGGTGAAGTGGGTTTTAACTATTGGTCTTTATCATATTAGAAATTAAAACTGAGACAATCTTAAAATATTTATTAATTAATTTAAAAATGATAATAAACTCACTACATCTTAATATAAATAAAATTTTTGTGAAAATAACTATTTTCTGGCCAGGCGTGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGTGGATCACGAGATCAGGAGTTCGAGATCAACCTGGCCAATATGGTGAAACCCCATCCATCTCTACTGAAAACACAAAAATTAGCTGGGCATGGTTGTGCGTGCCGGTAGTCCCAGCTACTTGAGAGGCTGAGGCAGAAGAATCGCCTGAACCTGGCAGGCAGAGGTTGCGGTGAGCCGAGATCATGCCACTATACTCTAGCCTGGGCAACAGAGTGAGACTCCATCTCAAAAAAAAAAAAAAAGAAAAAGAAAAAGAAAATAACTATTTTCCAAAACAAAAAAATAAGAATGGTGACATTGTTTTGCATTTTTGCTTTAATATCTGGCTTAATCAAAGAGAATGAAATTTTCCTATTTACTCCTACATTCAAACCGTTGCAATATTACACATAAAGTAGCCTCTGATAACTCTCCTGTATACTTGTTTTGTTTTTTATTTTTTTAAATCACTTTCCCCAGAAGGAAACAATCTCCTGTATATTTGTAAGAGAATGAGAGTGGAAAAAAAAAGTCTTAATATCATTCTAAAAATAATTCTGACCTCTCAGATATTCTGATGCAATCTCGGGGATCCCTGGAGTAGGGGAGGTCCCTCGACCACACTTTGAGAAGCACTATACCTGAAGAACTTTGGAAATCCCTTCCAATTAGGCGTTAATAGCGCTATATCTAAATTTATAATACGATTTTTTTTTTTTTTTGAGACAGGGTCTCACTCTGTTGCCCAGGCTGGACTTCAGTGGCCCGATCTTGGCTCACTATAATCTCCACCTCCTGGGTTCAAATGATCCTTCCACCTCAGCTTCCCAAGTAGCTAGGATTTATTTTTTTATATTAAAGTAACTTATACAATTGCCTTAGATTCTCCATTTGCTAATTTATTCAACAAATATTTACTGAACAACCAACATATGCCAGTCACTTTTCTAAGTGATGGAGACGTAGCAATGAAAACAATAGATATGATACCTGGCCTAAGAGTGCTGATATTCTAGTGGAGAGACAACAATATTCAGGTTTTTAAAAATTACATGTATATGTGTATACACACACATTTTTTTTCAGTAGTAATAAGTGCTATGCAGCATAAGGGGATAAAGAGTGCTGGTGGGGCAGGCCAGGGATGTGACTCTTTTTAAATAAGGTGTTCAAGGAAAGCCTCTTTGAGGAGGTATCATTTGCTCAGGGACCAGATTGAAGAAAGCAAACCAGTAAGGGGCATAGAACTGTTGGAGTAAAATGCAAGCCTCTGTTTCTCTGGCCACTTTGACTAATTTAGTGGAGAAGCCATGGGTCAGGGTGGACCATGAACAAAGGGAACCAGTTCACAAGAGGGCCAGAGAGCTGTAAGATCCTAAGAAGAAAGAGCCAGGAAGTCAGCAGGAGGCAATGTCTTTAAGACTCATAGGGCAGTAGCGGTACATAGAGGGTTTCAGAGAATCTTTTTTTAATTAAAAAAAAAATTTTTTTTTAATTTGAGATGGAGTCTCGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCGCCATCTCGGCTCACTGCAACATCTGCCTCCCAGGTTCAAGCGATTCTTCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGTGCCAGCCACCATGCCCGACTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGCTGGTCTGGAACTCCTGACCTCTGGTGATTCACCCACTTCGGCCTCCCAAAGTGCTGGGATTAGAGGCATGAGCCACCGTGCCTGGCGGGGCTTCAGAAAATCTACATGAAGACAGCAAGGGTCTTTTATTCCACATTGCATACAGTGTAATTTTCATTTTACTTCTAAGGTACTGTTTCATCTGTCTTCCCCACAG
Seq C2 exon
CTCATTAAGAACACTCAGACTTACACCTTCACCATCAGCCAAAGTGTGCTGGTCACCAACTTGAAACCAGCAACCATCAAGGTCTATGACTACTACCTACCAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSG00000166535:ENST00000299698:33
Average complexity
IR
Mappability confidence:
NA
Protein Impact
ORF disruption upon sequence inclusion
No structure available
Features
Disorder rate (Iupred):
C1=0.000 A=NA C2=0.000
Domain overlap (PFAM):
C1:
PF076779=A2M_recep=FE(25.0=100)
A:
NA
C2:
PF076779=A2M_recep=FE(38.6=100)
Main Inclusion Isoform:
NA
Other Inclusion Isoforms:
NA
Associated events
Other assemblies
Conservation
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
No suggested primer sequences
R:
No suggested primer sequences
Band lengths:
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Autistic and control brains
- Pre-implantation embryo development