HsaINT0076394 @ hg19
Intron Retention
Gene
ENSG00000160883 | HK3
Description
hexokinase 3 (white cell) [Source:HGNC Symbol;Acc:4925]
Coordinates
chr5:176308945-176310870:-
Coord C1 exon
chr5:176310771-176310870
Coord A exon
chr5:176309129-176310770
Coord C2 exon
chr5:176308945-176309128
Length
1642 bp
Sequences
Splice sites
5' ss Seq
TCGGTGAGG
5' ss Score
8.99
3' ss Seq
GTTGTCTGGCCTCTCTGCAGGAA
3' ss Score
9.89
Exon sequences
Seq C1 exon
GCAGTGGAGCTGAATGTGGTTGCCATTGTCAATGACACGGTGGGGACCATGATGTCCTGTGGCTATGAGGACCCCCGTTGCGAGATAGGCCTCATTGTCG
Seq A exon
GTGAGGAGGGCCCTGCCCTTTCATGCCCCTACTGCTTGGCAATTTGCTGCCTTCTGTTGATTCCTCTGGTTGGATGTTTCCTTGGCGGTGGGGATGTGGGATTGCTCTGGTCTGACCCAGTAGGGCTCTGGAACAATCTCTTGGGCTGGCAGTTTGGAGCTTGGGTGTATAGTCCAGCTCAGTGACTGACTCATGGTCATTTAAGCTCTCTGAACTTCACTTTGCCCATCTGATAAATGAATCTGAGCTTTGGAGTTGTACAGATTTGGGTGGAAATACTAGCTTTGTGTTTCCACCTGTATGACCTTGGGCAAGTCACCAGAGCCTCAGTTTCCTCATCTCTAAGATGGAGATAAGAGTAACAATGCCTGTCTCAAGGCATCATGAGGATGAAATGGGAGGGGACAAAATACAGCATGGTCCCTGGCTCATGGTACACACCTGGTGTTTGGAGCTGGGCGGGGGCAGGGGACCAATGAGCAATGAGGGTCCTTCAGACAGTCCAAGATTCCATCCTTATTAAGCACCTACCCTGTGTCCACAGGGGACTGGACAGAGGAATAGGAAGACACATAAAACAAGAGGCAATTTCTGCCTTCTCAGAACCGACCACTCAGCAAGGGTTAAGCCCAGAACAACACGTAGCGGTCAGAGAGTGACTTGATTCTACACGTGGGCAGCAGCGAGGCCAAGATCAGGAAGGAGTGGGTCCCAGGATGAGTGGAACTTGAAAGCCCTGAAAGAAAGGATTTGGCTCTGTTGGGGAGGAGGGATCCCACAGCTCCTGGGGCATTGGTCTCTCAACACGAGGCATGTGGCAGCCTCTCTTGAGGGGGAGGTTTTTGAACCCAGCACCTGGCACGGTTAGGCACTTGGGAGAGGCATGCCCAGGTTGCTGTGTGCATAAACAGCTGGACAGAGGAGCTCCAGGTGGGGCCAGCAAGGAGCCCACCTTCCTGGAGCTGAAGCTGTGTCAGAGAAAGGAAGGAGACGCCCTCATCCAGGGTGCGTCCTCTGCCTGGAATGCCTTTTTCTTTCTGTGCTTCTTGGATTCAGTCACTTCCTCTCTGTTGCTTTCCTGATCCTGTTGGCAGAGACTCGCCCCGTGGTCTGGGCTCCCACGATGCTCTCCTTGGTGCTTCCACGGGGGCACAGAGGCTCTGTCAGAGCTGGCTATTCATTGCCTGACCTCTGGCCAGACTGTGGGGCTCCTCGTCTCTGATTTCTCTGTGTCCCCTGCTCTTGGCCCAGCACCTCTTAGTTGGATTAAGGGCCTGGCAGGCCGGTCCAGGGAGCTTCGGCCTCTCAACCGCAGAGAGCTAGGGGCGAGGGCGGGGGATGTCACATGTCTCCCAGGGGAATGACAGGACAGCTGGGCATTGTAGGAGCACTTGGGGGTGGCATGGTGGATGCACTGATGGTGATGTTGGTGGGAAAGGCAGTGAAGGTCCCCAGGGCTTGGAGCTGGCAGGGTCTGCACGAGGGATGTCGGGAAGGAAGAAGGACCAGGACCAGGGACAGGCTGTGAGCATGAGAGGTAGAGAGAGTGAGCCCGAATCGTTGCCATCTCGGTATGGGAAGTGCTCAGAGGGTCCTTGTCTACATCAGTAAGTAGCTTCCACGTTGTCTGGCCTCTCTGCAG
Seq C2 exon
GAACCGGCACCAATGCCTGCTACATGGAGGAGCTCCGGAATGTGGCGGGCGTGCCTGGGGACTCAGGCCGCATGTGCATCAACATGGAGTGGGGCGCCTTTGGGGACGATGGCTCTCTGGCCATGCTCAGCACCCGCTTTGATGCAAGTGTGGACCAGGCGTCCATCAACCCCGGCAAGCAGAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSG00000160883-HK3:NM_002115:15
Average complexity
IR-S
Mappability confidence:
NA
Protein Impact
ORF disruption upon sequence inclusion
No structure available
Features
Disorder rate (Iupred):
C1=0.000 A=NA C2=0.000
Domain overlap (PFAM):
C1:
PF0034916=Hexokinase_1=PD(41.1=67.6),PF0199611=F420_ligase=FE(31.1=100),PF0372711=Hexokinase_2=PU(10.7=23.5)
A:
NA
C2:
PF0372711=Hexokinase_2=FE(25.4=100)
Main Inclusion Isoform:
NA
Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
NA
Associated events
Other assemblies
Conservation
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
AGTGGAGCTGAATGTGGTTGC
R:
CTGCTTGCCGGGGTTGATG
Band lengths:
280-1922
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Genotype-Tissue Expression Project (GTEx)
- Autistic and control brains
- Pre-implantation embryo development
Other AS DBs:
FasterDB (Includes CLIP-seq data)
AS-ALPS (AS-induced ALteration of Protein Structure, links to PINs)
APPRIS (Selection of principal isoform)
DEU primates (Only for human)