HsaINT0082964 @ hg19
Intron Retention
Gene
ENSG00000105855 | ITGB8
Description
integrin, beta 8 [Source:HGNC Symbol;Acc:6163]
Coordinates
chr7:20438483-20441749:+
Coord C1 exon
chr7:20438483-20438617
Coord A exon
chr7:20438618-20441343
Coord C2 exon
chr7:20441344-20441749
Length
2726 bp
Sequences
Splice sites
5' ss Seq
GAAGTATGT
5' ss Score
6.97
3' ss Seq
CTTTTTCCTCCTAAATTTAGGTT
3' ss Score
10.71
Exon sequences
Seq C1 exon
AAGCTCATTTCAGAAGTGAAAGTTCAGGTGGAAAACCAGGTACAAGGCATCTATTTTAACATTACCGCCATCTGTCCAGATGGGTCCAGAAAGCCAGGCATGGAAGGATGCAGAAACGTGACGAGCAATGATGAA
Seq A exon
GTATGTGGGTGTGCATTTTTCCCTTTTAAAATAAACTAAGTTGTTTGGCGTACTTTCTTACAGAAAAAGCAAACCATTCTGAAAAATTTTACTTACTACTGACTCTAAGAATCTTATTTATACTTCAAGGAAACTTTCATTGTCTCTCCTCAAAGTTCCTACTTGTTTTAGCTCAGCTGATTGTTCTCTCCAACTCTCAGGTTTTAATATGTATATGTGTGTGCGTGTGTGTGTAATATGAAACAATCATGTATCAATAGTAACTTTAAACTTAGGCGTCATGACCGGTATAAATTAGGAAATCACATATTCTCAAATAAGTAGTGTCTGTACTTATAATAATGATAATGCCTTTTTGATTTCATATTCACAAACTCTCAAAGTAAATGTAAAATTGAAAGTCACATATCACAGAAAAGAATGGGAATGATAGAACAGTTGATAAAGGCTAAGAATTTCAAAATCTTTCACTTTGTGATTGCCCCAGTACACTCATAATTATCTAAATTATCTAGAAGGAGGTAGGGAAATTTATTAAGAACAATACAAAATGGGAAGAGTCATCATTTACCAAAAAAAAAAAAATGGGATGTAAAGGAGAGAGATCCAGATTGTAACAGTATCAGGAAACAGCACCAGAGGAGATAGAGATTCTCCAAGGATTGGCACAACGGAGAGAGTAACACAAAGAAACATACTCTTTAAGGGAGTCTTTGCTGGGTGAAGTGATTTTGATTGAGTCATTTACGTCATGAGGCATTGTCTCATGTTTAAATGAATGACTTGGACTAGTAGATTTCCAACCCCTTTTAATCTAAAGTGCAATGATGATTAATTATGTAATGTCATGCTATAGAAAAAAAGAAAAAGTTATTGAAAGTGATAGAAGATTCTAAAAATGAATAAAAGAGACTCTTCTCTTTAGTTAGAATATGTTTTTCTATCTTAGGAATTTTAGAGCTGTGTATTTTAAATTAATTATTGCAAGTTTCTAATTCTGTGGTTTCTTCTATGATCACTCCGTGGATTTTGTTCAAAGGACATCATATACCAGTTTGCAAAATGCACTTTGGCTTTTCATTAAAACTACAGAGAAAACTTTTTACTAGCAAATATAGCACTAAGTTACTTTATGAAAAAACGCTTACTGTCTTAGAAATAGTTATTTCCTTCAAAATGTCATTTTGGAAGAATGGTTTTTCTTAGCTTTTACATTGTTTTTTTTCTTTTCATTTGCTTACATGCCATCTTTCCTTCATTTTCAATTGAGTAGTATAAATAGTTTAACTCTCAGGAATAGTCATATGACCTCTTAATTATAGAAACCCCAGAGTATGATCTACTGTTAGAGATGGCAGTGGCCACATTAACTTATGTATCTGTTAAGCTTCAGCATTCTCAAAGACAAAAGCATTTTAAGCATAACACCAACTGTATTGATTTTAATATTATGGAACAAATTCTAATGTTTCATGTATATATAAGCCAAATTTAGATACTTTATATTATTATATCGTAGATATATATTCCAACCAAAAAGCTCAGCGCAAATTAATTTTAAATTGTAATGGATCTCAATCCAACGTGAAAGAAATATACCTTCTTATTTACCAAAGTACCTAAAGATGGTAAGGTGAGCCAACAAATATAAATAGACATATTAAATCAATTGTGTTGTGCAAAAAGAAGAAATAGAGAAAAAGAAAACATTTGACCAATTCCTGCCAGCACAGCTCCTTAGTTCTGGGCTATCTTCTTCCATGGAGACAAATAGATAACCTGTGTTGAGGTCTTAAGATTTGCAAATGAGAGTCCTAAACATTTTTCTTTCGAGTAACATCAGAGAAGGCCACAGGTTTTCCTCCACTGAAACCCTGTATAAACTAAAATTTAACTCCGAAACTTTACTTGGGCTCCTAGAAAATAGGAACAAAATTAAAACTGTTCATTTGAACATCTTATCTCAGGGTTTTGATTTTTATTTATTTATTTATTTTTGAGATAGAGTCTCGCTGTGTCACTCAAGCTGTAGTGCAGTGGTGCAATCTCGGCTCACTGCAACCTCTGTCTTCCGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCTCCCAAGTAGCTGAGACTACAGGTGCGCGCCACCATGCTCAGCTAATTTTTGAATTTTTAGTAGAGATAGGGTTTCACCATGTTGGCTAGGCTGATCTCGAACTCCTGACCTCAAGTGATCCAACCGCCTAAGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCACGCCAGGCCTCATCTCAGGGTTTTAAACCAGTAGAGCAGAAGCCCTTTACTTTGGTTTATGTGATCTATCTCTAGTGTCAAATATTCAATACCCCACATTTTAATGGCTGAGTTTAGAAAATGGCCTATTCTTTCTCATGTTTGCTAAGAAATTAATCATCAGTGATGGGGTAGATGCTTCAGATAGGCTTGCACTCAAGTCTATTTAATGGTGCAATATAGGGATTAGTAGTTATTATATTCTTTAACCCTCAAGTTCATTCATTGGAAAATAAATGACTTTAAAAAGAGATGTTGCATATATATGAAAGAGATTACATGTGTTTCTTTTACAAATATCGTTAATTTCTCTAAGATGGTTTCTTATCAATTCAGTTATTAACAGATATAATATTGGTAATAAAAATAATTAAGGTATATAAATATATTTCCTTTTTCCTCCTAAATTTAG
Seq C2 exon
GTTCTTTTCAATGTAACAGTTACAATGAAAAAATGTGATGTCACAGGAGGAAAAAACTATGCAATAATCAAACCTATTGGTTTTAATGAAACCGCTAAAATTCATATACACAGAAACTGCAGCTGTCAGTGTGAGGACAACAGAGGACCTAAAGGAAAGTGTGTAGATGAAACTTTTCTAGATTCCAAGTGTTTCCAGTGTGATGAGAATAAATGTCATTTTGATGAAGATCAGTTTTCTTCTGAGAGTTGCAAGTCACACAAGGATCAGCCTGTTTGCAGTGGTCGAGGAGTTTGTGTTTGTGGGAAATGTTCATGTCACAAAATTAAGCTTGGAAAAGTGTATGGAAAATACTGTGAAAAGGATGACTTTTCTTGTCCATATCACCATGGAAATCTGTGTGCTG
VastDB Features
Vast-tools module Information
Secondary ID
ENSG00000105855-ITGB8:NM_002214:9
Average complexity
IR-C
Mappability confidence:
NA
Protein Impact
ORF disruption upon sequence inclusion
No structure available
Features
Disorder rate (Iupred):
C1=0.022 A=NA C2=0.000
Domain overlap (PFAM):
C1:
PF0036213=Integrin_beta=FE(10.6=100)
A:
NA
C2:
PF0036213=Integrin_beta=PD(12.3=30.1),PF079748=EGF_2=WD(100=26.5),PF079748=EGF_2=PU(28.6=7.4)
Main Inclusion Isoform:
NA
Other Inclusion Isoforms:
NA
Associated events
Other assemblies
Conservation
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
No suggested primer sequences
R:
No suggested primer sequences
Band lengths:
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Autistic and control brains
- Pre-implantation embryo development
Other AS DBs:
FasterDB (Includes CLIP-seq data)
AS-ALPS (AS-induced ALteration of Protein Structure, links to PINs)
APPRIS (Selection of principal isoform)
DEU primates (Only for human)