HsaINT0088905 @ hg38
Intron Retention
Gene
ENSG00000164344 | KLKB1
Description
kallikrein B1 [Source:HGNC Symbol;Acc:HGNC:6371]
Coordinates
chr4:186232127-186234058:+
Coord C1 exon
chr4:186232127-186232289
Coord A exon
chr4:186232290-186233951
Coord C2 exon
chr4:186233952-186234058
Length
1662 bp
Sequences
Splice sites
5' ss Seq
AAGGTAAAA
5' ss Score
8.38
3' ss Seq
TAAAGCTACTTTTAAAATAGGTT
3' ss Score
4.04
Exon sequences
Seq C1 exon
GATGTCTGACTCAACTCTATGAAAACGCCTTCTTCAGAGGTGGGGATGTAGCTTCCATGTACACCCCAAATGCCCAATACTGCCAGATGAGGTGCACATTCCACCCAAGGTGTTTGCTATTCAGTTTTCTTCCAGCAAGTTCAATCAATGACATGGAGAAAAG
Seq A exon
GTAAAAGTTGGTATTTCATTATTGGAGAAGCTGTTTTTCAAAACTGAATCAGTTTTGTGCAGAAAGGTGTAGTATAACTGAGAGTTCTTCCTCACACGGGGTTCAAGGACCAGCTTCAGCAAAATCCCGTCAAGTGGTTCTTACAAATGCAGATTCCTAGGCCACAACCCAGATCTGCTGAACCAAAGTTTCTTGTGACCAGGAATCTGCATTTTAAACAATCACTGTGTTTCTTTAAAGTAGTAGAAGCTAGTCATTTTCTATTCAAAGCCTCAAAATGCTTGAATATCATTGGGCTAAGGGATTGTCTCAAGAAAGAGTCTAACAGGTGCACATTTCATCTGAATAAAGAAACAGATTTAACTGTGTGACCCATGATCACATTAGCGGATAGCACAGTCCAAAGAAAATAACATAAGACAAGCATTTTGCTGAGAATGTAATTGAGAAAGATCTAGAACTTGTGATTTTGGGACAGGGCAGTTCTAAATGGGGCCTATAGTGAGCCAGTTTGGGCACCTGTGGCATGATGCTATGTATGGTGTGTGTGTGTATGTGTGCTTGTGCTTGTGTGAATATGTATTATTAACTGGAAATTTGTAAAAGTATTGGAAAAATAGTACTTACGATTTTGTGTGTGTGTGTGATGGAGTCTCGCTTTGTAGCCCAGGCTGGAGTGCAGTGGCGTGATCTCGGCTCACTGCAACTTCCACCTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGCACGCACCACCACGTCCAGCTAATTTTTGTAGTTTTAGTAGAGACGGGGTTTCACCACATTGGCCAGGCTGGCCTTGAACTCCTGACCTCGTGATCCACCTGCCTCTACCTCCTAATGTGCTGGGATTACAGGCATGAGCCACCGCACCCAGCGGTAATTACAATTTTTATTAGGTCAGAGAGATGCTTATTAATCACGAGCCACAGTTTCATCTTAATGATTTTTCCTTTTGATTAATATCCAGAGTAAGCTTTTCTTTGTTGTTCCCATTTCCATGTTCATAACTCTTTACTCATCTTCACTCTATGTGAGTTTACCAACTAGAAATTGGATAGTCATTCTCTGATCCCACATGTTAAACTTGTAGAGAAAACTCAGATTGTATGTGAGGATCATCATATTAAAAGTGGAGGAAGGTTCTAGAATTCTTATAAATAATGAAATTAACATGAAGGTGGACATCTAAGACAGAGGGAAGTCTTCCATTAAGTGCAGACTACAAGGAGTTAATAAGCAAGATGAACACGATATACAAATCCAGCTCTTATCACTAAGTTAACTTTTTAAGTAAATGAAAGTATTTGCAAAAATAATTACCAATTGAGAACATAGTTGCCTGAAAGTTTAAGAACACAGGAAAAATCATTAACTCTTTAATATGGTTGATTTCCTGTACTTAAAAAATGTGAGTGTAAAGAAAACGCAGTGATGGAGTTAGATATTATGGGGTGTTATAAAATTAGCTCTAAGAGTGTTCTTTCCAGCAAGTATTGGGGAAGCTATATTATTTTCCTTATTCCTGGTTTTATTTGTTAGTGTGTAGAAAATGCTAGACATTTCCTCAATGTATGTTTATTATTCTACTTCCTAAGTAAAGCTACTTTTAAAATAG
Seq C2 exon
GTTTGGTTGCTTCTTGAAAGATAGTGTTACAGGAACCCTGCCAAAAGTACATCGAACAGGTGCAGTTTCTGGACATTCCTTGAAGCAATGTGGTCATCAAATAAGTG
VastDB Features
Vast-tools module Information
Secondary ID
ENSG00000164344:ENST00000264690:3
Average complexity
IR
Mappability confidence:
NA
Protein Impact
ORF disruption upon sequence inclusion
No structure available
Features
Disorder rate (Iupred):
C1=0.000 A=NA C2=0.000
Domain overlap (PFAM):
C1:
PF0006717=p450=PD(2.9=3.6),PF0002421=PAN_1=FE(62.8=100)
A:
NA
C2:
PF0002421=PAN_1=PD(34.9=81.1)
Main Inclusion Isoform:
NA
Other Inclusion Isoforms:
NA
Associated events
Other assemblies
Conservation
Zebrafish
(danRer10)
No conservation detected
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
GATGTCTGACTCAACTCTATGAAAAC
R:
CACTTATTTGATGACCACATTGCT
Band lengths:
270-1932
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Autistic and control brains
- Pre-implantation embryo development