HsaINT0088945 @ hg19
Intron Retention
Gene
ENSG00000111796 | KLRB1
Description
killer cell lectin-like receptor subfamily B, member 1 [Source:HGNC Symbol;Acc:6373]
Coordinates
chr12:9754097-9760497:-
Coord C1 exon
chr12:9760351-9760497
Coord A exon
chr12:9754196-9760350
Coord C2 exon
chr12:9754097-9754195
Length
6155 bp
Sequences
Splice sites
5' ss Seq
GGGGTAAGT
5' ss Score
9.65
3' ss Seq
TTTTCTTTTTAACTTTTCAGATG
3' ss Score
11.5
Exon sequences
Seq C1 exon
GCCTCACAGAATTGAGAGTTTGTTCTTACACACAAGTTTAATGCCACCTTCCTCTGTCTGCCATGGACCAACAAGCAATATATGCTGAGTTAAACTTACCCACAGACTCAGGCCCAGAAAGTTCTTCACCTTCATCTCTTCCTCGGG
Seq A exon
GTAAGTGGCTTTAATTTTCCTTTCGGCATTTGTATGTCTTCCAGAATTAGATCTTCCTGTTACATTTATGGCTTTAAATCATTGCTTTAAAGATGAGCAGTAGTTTTATATTAATGTTTAACGGGTGTTGCATGGCTTGCCTGTAGATAATCACAACTTTGGGAAAAAAAATTTAAACCTCATACATTTATTTTTTTCAATCAAGTTAGCATGAAAAGCAAACATCACTTGTCTTACTGAGCCTTGGTTAAAAGACTCTGAACACTTTAGGCTACCCTGGGCACACTGCCTATTGGTTACCCCTGCTCTACAGGGATGGAAAGAAGGAAGAAAGAAAGAAAGAAAGAAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGGAAGAAAGAAAGAAAGAAAGGAAAGAAAGAGAAAGAAAAGAAGAAAGAAAGAAAGGAGAGAAAGAAAAAGAAAGAGAGAGAAAGGAAAGGAAAGAAAGAAAAAGAGAAGGAGGAAGGAAGGAAGGATGGAAGGAAGGAAGGAAAAATATTTTACATGTATGAACTAAGGAATATTTAAGACACATTGCAAACTTGCTGTAATAACAACCTACGTTATTCCAAATTCCTCTACAAAATATCAATACTATGATTAAGTCCCAGTGCATTTTCATCCATAATATTCCTTTCAGAATACAACGTGTAGGCCAGTTGCAGTGGCTCATGCCTGTAATCCCAACACTTTGGTAGGCTAAGGTGATTTGCTTGAGTCCAGGAGTTTAAGGCCAGCCTGGGCAATGTGGCAAAACCTCATCTCTACAAACAATACAAAAAAATAGCCAAGTGTGGGGCACGTGCCTGTGGTCCTAGCTACTCGGGAGGCTGAGGTGAGAGGATTGCTTGAGCCCAAGAGATCAAGGCTGCAGTGAGCTGTAATTGTGCCACTGTACTCCAGCCTGGGTGACACAGCAAGACTATCTCAAAAAAAAAAAAAAAATATATATATATATATATATATATATACTTTTTATACATATATTTTATATATTTTATATATATATATATACTTTTTATACATATATTTTATATATTTTATATATATATATATAAAGTGTAGGCTTAATGAGTAACATACTTCACTCTCTCAAGAGAGGGGAACACTTTCTGGAAAAAAAATCATATTCAAGATCAAAGATTTGAATATCATTACTACCTGATAGTTTCTAGTTTGAAAAGTATCACAGCTTAGAAAGAGACAAGCCACAAAAATACTCGAGCATATCAGTAACGAACCTACTTACCATTTGTTGAAACTGGCACTTTCCTGTGTCTCTGAAGAGTTAGCATTCTGAGTGAAAGAAGCGGGGAACACCAATGTGAGGTAACACATGATGGATAGCATGGCCTGTGGATGGATGGGAAGAAACTAGAAACTGAGGCAGAAAATCAGCATGAAATTATTATGACACATTATTATTTTCTGATATCTAACTGAATTTACTATCATTGATAATATTACAATTGTTTACCAATCTGATATTCATTCCATGTCATGCCAAGCATTTGACTTGTGCTGTTTTAAGACTGTTTAAGTTTTAAACTATTGAATTCTCAAAGTTTTAAGTCAAGAAGAAAGTCTTAGAGCCGTCAATTAAGTTTCAGTATAATTTTCACATAAGAGTAGAGGAAATCAGAGGGTTCTAATAACTATAGGGAGGATTTGGTTGAGTAACATTTTTTTTTAAAGAAAAGAGTAAGTCTTTCTTTTCCTCTATTCATATCTAGCAAAAGGTGGAAAGTGGGCTTTTGTCAGAAAATGAATATAGAGGTAGTGAGACTCTTCCCAAATGTTGCTATGATCCCAAACCAATGGATGCAGAAATTTTTTCTACTTGGATTGTAATAATTATCCTATAAAATGTCATTCTGAGAGTAAACCTGAAGAAAAAATAAGAGTAGAATAAAGCCAGAGCAAAATATGTGACTATAGAACACTGGTCTGATATTGAATGACAGTAAAACCACTATTGGTCTCTGGCTAAACTGCTGAGGCTGTGGTCACTCTGTAGCAAGCACGGTGATTGTGTCTAAGGCAGTCAACAAAACCAGAAGGAGAGATGTGAGTGATAACCGATCTTGCTTATGGCCAAATGGCCAAGGGTTTGGTCTGTTAGAAAAGTGGATAAGGTGTTTGCAAAAATGCCCCTAGAGTTTATTCATTCATTAAAAAATAAGCTCCTACTCTGCACCAGGCATGCTGTGAATACAGCAGTGAACAAAATAGAGAAAATTATTTTCCTTCATAGAGTTTATAGTAAAATAGAGGCACACTTGTGGAAGACAGTATGGCGATTCCTTAAGGATCTAGAGCTAGAAATACCATTTGACCCAGTGATCCCACTACTGGGTATATACTCAAAGGATAATAAATCATGCTGCTATAAAGACACATGCACACGTATGTTTATTGCGGCAGCATTCACAATAGCAAAGACTTGGAACCAACCCAAATGTCCATCATTGATAGACTGGATTGAGAAAATGTGGCACATATACACCATGGAATACTGTGCAGCCATAAAAAAGGATGATTTCATGTCCTTTGTAGGGACATGGATGAGGCTGGAAACCATCATTCTGAGCAAACTATCACAAGGACAGAAAGCCAAACACCGCATATTCTCACTCATAGTGGGAATTGAACAATGAGAACACATGGACACAGGGCAGGGAACATCACACACCAGGGCCTGTTGTGGGGTGGGGGTAGGGAGAAGGGATAGCACTAGGAGAAATACCTAATGTAAATGACGAGTTAACGGGTGCAACAAACCAACATGGCACATGTATACATATGTAACAAACCTGCACATTGTGCCCATGTACCCTAGAACTTAAAGTATAATAAAAAATAAAAATTAAAAAAATGGAGGCACACCATCAATAAAATAAACAAATAACTAAGTCAGTATAAAAGATGAGACGGTGTTAATGTTATTGAGAAAGATTTGAATATAGGATTTAACTTTCGGGGAGGGTAGCATATCAAACAGAATAATCAAGGAAGGCCTCCCTGAGAAGATGACATTGAGTCAAAACCTGACAGAAGTGAGGGACAAAGACATAAGCCCCTGAGAGAGAAGCCTTCTAGGAAGGTGACCAACAAGTGCAAACACATCGAAATGAAAACACGCCTGTGGTATTGTAGGAGGCATCTGCGTGGAGAGTGAGCGTATGGAGGCCAGATGGGGTGAGGGCAAAATGTGAAACCACTATTGGACTCTGGCTAAACTGTTGAGGCTATGGTCACTCTGTAGCATGGTGATTGTGTCTAAGGCAGTCAACAAAACCAGAGAGATGTGAGTGATAACATCCAACAGAAGTGGGCGCCAGCTTAAATAGGGACATATGAGCCATTCTACAGACTCAGATTTGCCTGATGAAAAGCCATTGGAAGGTTTAGAATAATGAAATGAGATGATTTCACATACTTTTTAAACTCAAATGGAGAACAGCCATAGGTAGGTATTTCCAGATAGCTAACGTCCGCCGGACCCCTGTAGTGATTCATTGTAACTTCATTAATTCTAATGTCACGTGGTGCCACAGAAACACAGTACAGGAGTACATTCCTCCCAGACACAGTACACTCCACTCAACTCCTTACATTTTAGCATGAATGAATAACGATTTTTAAAAGTCACCAAGTTGCCTTTTACCTATAGTTAAAAAAAAAAAACAACTTTTAGAAAAAAAGAACTGCTGTTCATTGAACAGTTACCATGTGCCAGACACTGTGCCCAGCATTTAGAAGAATTGTTTCATATAATCCTCTCCAAAATATTATGACATAGATAATATTCCACATTTCACAGATGAGGAAATCTGTGGGTTATGAAGGTTGAACGTATTTTCCAAAATAACATGTTCACATTCAGATTTGCTAGATCGGAAAGACTGTTCTTAATCAATGTTAGCCTTTAGTAATGAAAATTACTAAATTCATGTTAGTAATAGAATTAGGCTGGGTGCGGTGGCTCACGTATGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGTGGATCACCTGAGGTTGGGAGTTCGAGACCAGCCTGACCAACATGGAGAAACCCGTCTCTACTAAAAAAAAAAAAAAAAAATACAAAATTAGCCGGGCATGGTGGCGCATGCCTGTAATCCCAGCTACTCGGGAGGTTGAGGCAAGAGAATTGCTTGAACCTGGGAGGCGGAGGTTGCGGTGAGCTGAGATTGCACCATGAGCCTGGGCAACAAGAGTGAAACTCCGTCTCAAAAATAAATAAATAAATAAATAGAATTAAGTTAACACTTAAAATAGTGACTATACAGAGCTTTCTCCACTAGACAAACAAACTTAGAGTTTCAAGGAAGAAAACGGTGGGGAAGAGAAGAGACAGAAAGGTGAAATAACGTACATATATAAAACTGGAAGGAAAGCCATGCCAGTGCTGTCTTGGGCTTATTGACTGCATGTAGACATTCTTGTATCACACCAGCTCTCATTAGAAGTTCTAGGCCAATATTACCAAGCTTGGTTTCCTCACATTCAGATATATCCCTGGGGCCTTGGAGTCTCCTCTAGGTATCTACTCCTCCCTGCCCCCCTCCACTGATACAGCATGTCCTAAATAGTACCAGACGATAATCCATATGTTACAACCCTGACCCCAGTGTATTATGGTTCCTCCCATAATCTTTGATCACATCTAACGCTACTAAATTCTATCTCCTCAGGGCCGTTTTAGAGAGAGCTGATTCACTTATATCAGTGTGAGCATCCTAATGTGAGAGATTATCAGGTCTGCAAACTGGACTGCACAACTTAATCCTCAAGGATACTGTACCATTAAAAGTAGAAATGGCTTCATGGCCGTTCTGAAACATATAAAGAGACTAAAGGATAATATTATAGTATATCTGATGCTAAATTTTTTAACATGTAACTCATAGCAAGTAATCACTTACATGGAATAATATTAGAAAAAATAAAAAGGAATAGACAATACAAATAAATCAATAGCTTCAGATAAATTAGAAAGCCTTTATTCATAAAAGCTCCTAGCTCTAATAATAGAATTTATAAAGTAATTTATAATTATAATATATCTAATATGTTAAAAACCAAATGAGAGCAGAGGGAGACTTACAATTAAATCAGAGATAGGGGAGCTATTTAGGCACAACTTCTAGCAGTGTAACTGAGCAATATACTACCAGAATAATTCCTTATCAGAGTTGATTTAATTTTGGAAGCTATATCCCAGTGTTTCTCCAAAATATTTTTATAAATCTCTCTTTATTTTTTTTCTATTAATTCATGTTTTCAAAGATACAGAGCAAAATACATTGATAAAGTTGCGATTAATTTATAACATTTCATCAATATAATCATAACTTTTGAAGAACATGGGAGATTCATTATATAGTAATTGATGTGATTACAGAGAAAAGCAGAGATATCTGACACTTGGTTTAGACTATGCGATGTTGTAGACATAAGCGCATGTTATGTTATACTAGTGATAATATTGAAAAAGGTATGCAGTCACAAAACCTTATCCCTTGATGGCTTGGGATCCCAAGTTGGCTTAGACCCAACTTGGAGATGATTGTTCTAGACAACAGCAAAGCAGAGGATTCCATGTCCAAGAATAGAATTTCTGTATACCACCAGCACCTAACATGGTACTTGGCACAAAATAGAGAGAGCCTCAAAAAATATCTTGACTAAATGAAGGTCTTCCTTCTTGGACAAAATGCTTTGACTTACTTCATACATTAAGACATGCACTTAATTTTTGTATAGCACTTGGCAATTTTCAAAACATCTTTCTATCTATCTCATTTGGTTCTTACACCAATCCTTTGTATACACACATGCATAAGCGTTCATATTTTATCAATGAGCAAACTCTGTTGGATCTGAGAACCCATCTTGCAGGACTCTACTTTTAGAATGATGGATAGAGGTTGTTCCCTGCCCCCATCCCCCAAGCTGAATCTAATTGTCCCTATGTTATCCCAAGTACATTTTTGTGCCAGATGTACTCCACTGAGTTAACCAAGGTTTTTTGTTTCGTTTGTTTGTTTGTTTTTGTGTTTTTCTTTTTAACTTTTCAG
Seq C2 exon
ATGTCTGTCAGGGTTCACCTTGGCATCAATTTGCCCTGAAACTTAGCTGTGCTGGGATTATTCTCCTTGTCTTGGTTGTTACTGGGTTGAGTGTTTCAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSG00000111796-KLRB1:NM_002258:1
Average complexity
IR-S
Mappability confidence:
NA
Protein Impact
ORF disruption upon sequence inclusion (1st CDS intron)
No structure available
Features
Disorder rate (Iupred):
C1=0.379 A=NA C2=0.000
Domain overlap (PFAM):
C1:
NO
A:
NA
C2:
NO
Main Inclusion Isoform:
NA
Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
NA
Associated events
Other assemblies
Conservation
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
No suggested primer sequences
R:
No suggested primer sequences
Band lengths:
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Autistic and control brains
- Pre-implantation embryo development
Other AS DBs:
FasterDB (Includes CLIP-seq data)
AS-ALPS (AS-induced ALteration of Protein Structure, links to PINs)
APPRIS (Selection of principal isoform)
DEU primates (Only for human)