HsaINT0101801 @ hg19
Intron Retention
Gene
ENSG00000157890 | MEGF11
Description
multiple EGF-like-domains 11 [Source:HGNC Symbol;Acc:29635]
Coordinates
chr15:66206075-66207936:-
Coord C1 exon
chr15:66207808-66207936
Coord A exon
chr15:66206312-66207807
Coord C2 exon
chr15:66206075-66206311
Length
1496 bp
Sequences
Splice sites
5' ss Seq
AAGGTAATA
5' ss Score
8.49
3' ss Seq
GGCCCTCCCTCTGCCCGCAGCTG
3' ss Score
11.76
Exon sequences
Seq C1 exon
GATGTGCCCCAGGAACCTTTGGCTATGGGTGTCAGCAGCTATGTGAGTGCATGAACAACTCCACCTGTGACCATGTCACCGGCACCTGTTACTGCAGCCCTGGCTTCAAAGGAATCAGGTGTGACCAAG
Seq A exon
GTAATACACACGTGGCAGAGCCCCGGGGTCTGTGGAAAGGGCCCCATGGCAGCTCTAGGGAGATTCCAACTCGAACAGCTGGATTTGATGATACTTCCCTTTATTCACATTTGTGAGGACAGCAGGAATAGGGTGGGCTGCAGAGGCTCCAAGTGCTGAAGAGGCATAAGGAGCAGGCAGTCTCTCAGTCACAGCCTCCCTAGGCTCACCCTTGGCAAGTTTCCCATGAGCCAAGCAAGGGTAGCCACAAGCTAGTACTATGGAAAGGCCACCAGACCAAGTTAGAATATCTGCCAAGTTCTGGTTCTGCCTTACCCGCCAGGTGTCCTTGGGTAGGTTATTTGATTTTGCTAGGCCTGTTACTCCACATGCAAAGCGGGAAGAGTAGATTAATCATCTTCCCCCATGACACAAGGTTACTCTGAAGGCCGAGGAGCCCAAAGGGGCTCAACCTTGGTTCTAGCACTACAGTCGGATGACACCTCATAGGGCCTAAAGGGGATGGAGTCCCAGGGTCCAGTTGTGAGAATCACGTTGAGACAGTATGAGTAAGAGATTCAGCGGGGTGCCTGGCCCATAAGTGAACACTCCAATAAATGCTGGCTTTGTTATATAAAAGCCTTTATAATGTGCTGCAAACATGTTGGTTCTAGATGGGGGATGAAAATGGGCTCTCAATTATTCACATTACAGAAAAGGAGCCAAAAGACAGATTTCCGTTGCATTCTGAGGATAAATCACTGAGAACGATATTGCAGCACATTTACCTCCCTAGTGATGTTGGCCAGCTCAGTTCAGCCAGCAGCCAACAGTCAAGGAGAAGTCTAGACACTGTGGGCCTGGCAGGACAGCCTCCTAGACTAAGCATCAGCATGGAGGGTGGGGGCAGCCCTCACATATATAACCAAGAGGGGTCCTGCGGGCAGTCATCCTGGAAATAACAGCACAGTACTTAAGAGCCTTCCTTGCCAGTCTATCACTTGGTGCTCACGACTGGGGAGGGTGGGGTTATTGTCCCCATGTTACAAATGAGCAAACCAGGGACTCTGAGCCACACAATTAGGAAGCAGGGAGAGGAGCTGTGTTCAATTTTTCCTGACTCCGCCAATTATAGGTTATGTAATCTTGGGCACATTACCTAACCTTTTGATAAATTGGTTTTTTCATCTGTGAAAGGAAAATACTAATCCCTTCACAGGGCTGAAGAGTAAATGAATTAATATCTGTTAACTCATTTTTGGAACAGAGTAAAATAATATTTATTGTTTCACATCGACAGTCACAATTGCTCCTTGTCATGACCCTGAGACTCCATCCCCTTTAGGGATGAAGGCACAGTGAGGGCTGGGGGTAGTCACATAGGGACTCAGGAATCGGGCCAAAGCCAGAACCAGATCTCCTAACATTAGAGGGGTTACACGCATCTGAACCCAGGCCCAGGAGACCTGAAGCGCAAGAAGGCCAGCCCCAGGCTCAGGCCCTCCCTCTGCCCGCAG
Seq C2 exon
CTGCCCTCATGATGGAGGAGCTGAATCCCTACACCAAGATCAGCCCAGCACTGGGTGCAGAGCGGCACTCGGTGGGTGCTGTCACAGGCATCATGCTCCTGTTATTCCTCATTGTGGTGCTGCTGGGCCTATTTGCCTGGCATCGGCGGCGGCAGAAAGAGAAGGGCCGAGACCTGGCTCCCCGTGTCTCCTACACACCTGCCATGAGGATGACCAGCACCGACTACTCCCTCTCAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSG00000157890-MEGF11:NM_032445:19
Average complexity
IR-S
Mappability confidence:
NA
Protein Impact
ORF disruption upon sequence inclusion
No structure available
Features
Disorder rate (Iupred):
C1=0.022 A=NA C2=0.053
Domain overlap (PFAM):
C1:
PF0005319=Laminin_EGF=PD(34.8=36.4),PF0005319=Laminin_EGF=PU(78.4=65.9)
A:
NA
C2:
PF153301=SIT=PU(91.4=68.8),PF055456=FixQ=WD(100=46.8),PF117433=DUF3301=PU(87.3=62.3)
Main Inclusion Isoform:
NA
Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
Associated events
Other assemblies
Conservation
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
GATGTGCCCCAGGAACCTTTG
R:
GTCATCCTCATGGCAGGTGTG
Band lengths:
343-1839
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Genotype-Tissue Expression Project (GTEx)
- Autistic and control brains
- Pre-implantation embryo development
Other AS DBs:
FasterDB (Includes CLIP-seq data)
AS-ALPS (AS-induced ALteration of Protein Structure, links to PINs)
APPRIS (Selection of principal isoform)
DEU primates (Only for human)