HsaINT0101801 @ hg38
Intron Retention
Gene
ENSG00000157890 | MEGF11
Description
multiple EGF like domains 11 [Source:HGNC Symbol;Acc:HGNC:29635]
Coordinates
chr15:65913737-65915598:-
Coord C1 exon
chr15:65915470-65915598
Coord A exon
chr15:65913974-65915469
Coord C2 exon
chr15:65913737-65913973
Length
1496 bp
Sequences
Splice sites
5' ss Seq
AAGGTAATA
5' ss Score
8.49
3' ss Seq
GGCCCTCCCTCTGCCCGCAGCTG
3' ss Score
11.76
Exon sequences
Seq C1 exon
GATGTGCCCCAGGAACCTTTGGCTATGGGTGTCAGCAGCTATGTGAGTGCATGAACAACTCCACCTGTGACCATGTCACCGGCACCTGTTACTGCAGCCCTGGCTTCAAAGGAATCAGGTGTGACCAAG
Seq A exon
GTAATACACACGTGGCAGAGCCCCGGGGTCTGTGGAAAGGGCCCCATGGCAGCTCTAGGGAGATTCCAACTCGAACAGCTGGATTTGATGATACTTCCCTTTATTCACATTTGTGAGGACAGCAGGAATAGGGTGGGCTGCAGAGGCTCCAAGTGCTGAAGAGGCATAAGGAGCAGGCAGTCTCTCAGTCACAGCCTCCCTAGGCTCACCCTTGGCAAGTTTCCCATGAGCCAAGCAAGGGTAGCCACAAGCTAGTACTATGGAAAGGCCACCAGACCAAGTTAGAATATCTGCCAAGTTCTGGTTCTGCCTTACCCGCCAGGTGTCCTTGGGTAGGTTATTTGATTTTGCTAGGCCTGTTACTCCACATGCAAAGCGGGAAGAGTAGATTAATCATCTTCCCCCATGACACAAGGTTACTCTGAAGGCCGAGGAGCCCAAAGGGGCTCAACCTTGGTTCTAGCACTACAGTCGGATGACACCTCATAGGGCCTAAAGGGGATGGAGTCCCAGGGTCCAGTTGTGAGAATCACGTTGAGACAGTATGAGTAAGAGATTCAGCGGGGTGCCTGGCCCATAAGTGAACACTCCAATAAATGCTGGCTTTGTTATATAAAAGCCTTTATAATGTGCTGCAAACATGTTGGTTCTAGATGGGGGATGAAAATGGGCTCTCAATTATTCACATTACAGAAAAGGAGCCAAAAGACAGATTTCCGTTGCATTCTGAGGATAAATCACTGAGAACGATATTGCAGCACATTTACCTCCCTAGTGATGTTGGCCAGCTCAGTTCAGCCAGCAGCCAACAGTCAAGGAGAAGTCTAGACACTGTGGGCCTGGCAGGACAGCCTCCTAGACTAAGCATCAGCATGGAGGGTGGGGGCAGCCCTCACATATATAACCAAGAGGGGTCCTGCGGGCAGTCATCCTGGAAATAACAGCACAGTACTTAAGAGCCTTCCTTGCCAGTCTATCACTTGGTGCTCACGACTGGGGAGGGTGGGGTTATTGTCCCCATGTTACAAATGAGCAAACCAGGGACTCTGAGCCACACAATTAGGAAGCAGGGAGAGGAGCTGTGTTCAATTTTTCCTGACTCCGCCAATTATAGGTTATGTAATCTTGGGCACATTACCTAACCTTTTGATAAATTGGTTTTTTCATCTGTGAAAGGAAAATACTAATCCCTTCACAGGGCTGAAGAGTAAATGAATTAATATCTGTTAACTCATTTTTGGAACAGAGTAAAATAATATTTATTGTTTCACATCGACAGTCACAATTGCTCCTTGTCATGACCCTGAGACTCCATCCCCTTTAGGGATGAAGGCACAGTGAGGGCTGGGGGTAGTCACATAGGGACTCAGGAATCGGGCCAAAGCCAGAACCAGATCTCCTAACATTAGAGGGGTTACACGCATCTGAACCCAGGCCCAGGAGACCTGAAGCGCAAGAAGGCCAGCCCCAGGCTCAGGCCCTCCCTCTGCCCGCAG
Seq C2 exon
CTGCCCTCATGATGGAGGAGCTGAATCCCTACACCAAGATCAGCCCAGCACTGGGTGCAGAGCGGCACTCGGTGGGTGCTGTCACAGGCATCATGCTCCTGTTATTCCTCATTGTGGTGCTGCTGGGCCTATTTGCCTGGCATCGGCGGCGGCAGAAAGAGAAGGGCCGAGACCTGGCTCCCCGTGTCTCCTACACACCTGCCATGAGGATGACCAGCACCGACTACTCCCTCTCAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSG00000157890:ENST00000409699:19
Average complexity
IR
Mappability confidence:
NA
Protein Impact
ORF disruption upon sequence inclusion
No structure available
Features
Disorder rate (Iupred):
C1=0.025 A=NA C2=0.071
Domain overlap (PFAM):
C1:
PF0005319=Laminin_EGF=PD(34.8=36.4),PF0005319=Laminin_EGF=PU(78.4=65.9)
A:
NA
C2:
PF0005319=Laminin_EGF=PD(18.9=8.8)
Main Inclusion Isoform:
NA
Other Inclusion Isoforms:
NA
Associated events
Other assemblies
Conservation
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
GATGTGCCCCAGGAACCTTTG
R:
GTCATCCTCATGGCAGGTGTG
Band lengths:
343-1839
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Genotype-Tissue Expression Project (GTEx)
- Autistic and control brains
- Pre-implantation embryo development