HsaINT0122127 @ hg19
Intron Retention
Gene
ENSG00000138735 | PDE5A
Description
phosphodiesterase 5A, cGMP-specific [Source:HGNC Symbol;Acc:8784]
Coordinates
chr4:120428759-120432289:-
Coord C1 exon
chr4:120432202-120432289
Coord A exon
chr4:120428860-120432201
Coord C2 exon
chr4:120428759-120428859
Length
3342 bp
Sequences
Splice sites
5' ss Seq
CCAGTAAGT
5' ss Score
9.09
3' ss Seq
GGTTTTCTTTTTTTATAAAGGGC
3' ss Score
5.54
Exon sequences
Seq C1 exon
AAGTGAACATCCACTTGCCCAGCTTTACTGCCATTCAATCATGGAACACCATCATTTTGACCAGTGCCTGATGATTCTTAATAGTCCA
Seq A exon
GTAAGTACCTAATTTATTGTTGTGGAATTTTAAAAGAGAGCTTTATAAATTCAGTTTTATTTTTAGTTCTTGGATTTATTCCCAGCATCATAAATTCTTGCACATACTTTATTCCTTTTTGGGTAAGGAAGGCGAAGCCAAAACATTTGAGATCCTCACAGCCTCACTTCTCTAGACAACCAGAACTGTCTACATGTTGCCCAATAAGGGAAATTTGGTTATTCTACTCTACGTGGCTATTCCAAATTAGAAACAAACAAAATGTGTATTTTGTGGCTCTCAGTTAATTCTGCTTTTTTTGTTTAATCGAATGAAGTGGTTTCTATAGCTCAAGCATTTGCTTTCACAAAGCAATACCCTTTCTTCTTTTTATTGAAACTTCCAGTCACTAAGAGAGGATTTTATTAAAGAATAAAGCTATTTAACTACTTGGTGAAATGAATATTTATCAACATAAGAAAGCATATGCTATGCTATGCTAAACATACTTATGTTAAGGAAAACAAGATTAACATAATATGCACCAGGATATTAACAATGGCTGTGCTGGTGTAATGAAATTGTTAATCTTTGTTTGGGGGGGATGGTTGTTCATTATTTACATTGTCGGCTGTGTGTATGTATTACCTTAATAATAAGAAAAAATGAAAGTTTTAACTATTACATTGAACATACACAATGCATGACATATAATCTTAAAGCAATTTTACAATATTGCTAAGTTTACTCAGTTGGGCTAATTCTTTCCTGAGCCCTGGAAAAAAATTCAGGGATTCCCATCACTTTTCTGGTCACTATTTTATAAGTAAAAGCCCTCTAGTTACTTTAGGTTCCAACATATAGTATAGAGTTCTCAACTCAGAAACAAAAATGTGTACTCCTGGGTAGCAGTCCAAATTTTGAACATGATTTAAAGTTTCAGGTTTTCTGTTACTGCACTGGTAGGCTTCTCCCATTCCCTACCTTGTGTTTCTTCTAACTCCTTCCTCTCTCCCCAACCTCCATGTGGTTTCTTACCTCTTCATACTTGGAGAATGGGAAGGGAGAATAGGTAAGAAACATCAAAACATTCTTAACAGACTGGTACTGATATGAGTGCCTTGCTTTTAGACTTTCCAGACAAGAGTCAGACACAAGTCTACTCTAGCCCCACCTCCACCCACTAAATGATAGGAGACATACACAGGAACTCCACACCCCTCTCTCTTACCTGAGGTAGAGGGGAACACACTCTCACGCCTCCCTCAACACCTCAGTGTCGGGGAGGAATTAAGAGTTATATAGCCTGTTTTGGCAACCTCCTTATAAAATCTGTATATGGTCTAGTACAGATTGTTTTTCTACAACATGTGACTGTTTAATGTGAATTATATCATGTGTGATTGGGAGGTAGAAGAATGGTATCAGTATACTATAGACGTTCTATCATTTCATACACGACTTCTCTGGGGTAAGAGGTGCCAGAATTATAGAAGTTGAATTCTGACCTTCAGCAATAAAGGAAAAAGCCCTCCCTTTGGCTCGTGCATATACAGCCCTTTCCATTCTATCTTAGGAATATTAAAAATGAGCACTTGCACCTGAGGCTCTCTCCCTCGCTTTGGACTGCTGTAGCCTCTTGGTAGCTTGCTCTTCTTTCAATGCCCACCTTAATAGCAGAGTTACTGTCTCAACAATCAATTCTATATGCATTATTGCAGGGCCCCTCAAACCAGCATTTCTACTTGATTGTTTTTGTCCATCTTTAATGTCCTCAGAAGCAGCCTCCAGACCTGCCAGACTGGCCTGTCCAAGTTACTTCCAGAGGAACCAATTCTTGGTTTAGTTTGTGCTCTGGTTACAAAGTTGCATAGGTTTTGAGTGGTCTTTCCCAATACCATTTTTTCACAAAATCCATGTTATTTTTAGTGTACGGTTTTTCAGAACTGAAATTTCTCAGGAATGTATATGTCATGTTATAGTAGGAACATCTGTACTTTTGCTATCTGTGTGTTTCCACTAAAACTTTCATTTCAGTATCCCACTACAAATTTAGCTCCAAAGAAAGAAAATATGCTTTTTTAAAAGCATATTTTACAGTATTCCTATCAACTGACCTGTTACTATATAACTTATTATGTAATATGTTGTTACTTAATATATAAGGAATCTGATTATCTATATGGCTGGCTCAAATTATAAGACCTATCTATATATTCTATCTTTGTAAGCATAATTACACAAGAAATTATATCCTCAGCTTTTGAGAGTAAAAAATAAAAATATAGCACCAAAAGACATTTCATCTTCCACTTGAAATTGTTTTATCTTAAAGTAAGTATCAGAAGGTATTTTCTGAATAGTTTTCTGTTTAGCCTAGAATCTAAAATGATTTAGTATTTAAAAATAATGTTTATGGTTGTAATTATAGATTATTGTCATTAATTAGATCCATGCCACAATTTCAGCATCTAGTTATCCTTTAATCAATGTGTTTTGGCCCCAGCCTAACATACCCAGAAGTTCTCCTGTCTTCATAACAAATCCCTTGCCTTCAGATCTCATTCCTAAGCGTCTGGGTTTTTTCTTGGCCCTAAGATATAGGAAGCACATCTGACTCAACTTACAGATGTTGTTTTGATTGTATTCTGAGTGCATGGTCTGTGTATTTTACTTAGTTCAAGATTAGAGAACCACTATGCTTTAAATTACAGATAAGAAATAAAAAATGGTTACATAGTGAAAACTTTGAATGATTTGCACATGGATTAGCTACCTTTTAAATATTCCTTATAGATGTTTCAACCCACGCTTTCTTTCACCACTGACCAGTAAGCACCCTTTGGCTCATGCCCTTTACCCATCTATATTAAGATGTTCCTAAGGAATATGCACTGTTATCATAACTGACCAAGTTAAAATTATATAAATTTGCACCAGAAATGTTACTGGATTTATTTAAAATGCCATAGAGAAGTTTAAAAATTTTACCACTTCTTTCTTCATATCCATTAATATGGCTTTTTTTTCAAAGTTTTACATGCTGTTAAATTATAGCGATTAGTCTGCCCTACGGAAAAGGATAGCTATTAGATTTTAAGTCTGGACTAAGGCTTAAGGAGTATAAGAGTTGGAAAAACATGCATATGTAGGCAGATGAAGCATTATGAAGCGGTTTACATGTATGACAGAGGGGTTGGGTGGGAACATAGAGGGGAAACTTTATTTCATGGTATTTAAGTGTGTCCTCCACATTCATTAGAATACTGGGCATGTGTTTAAGATATGTGAATATATTTCTAGATTTTGTTCTTGTCAGCAGCTTCTCCAGGATGTTAATACTGGTTTTCTTTTTTTATAAAG
Seq C2 exon
GGCAATCAGATTCTCAGTGGCCTCTCCATTGAAGAATATAAGACCACGTTGAAAATAATCAAGCAAGCTATTTTAGCTACAGACCTAGCACTGTACATTAA
VastDB Features
Vast-tools module Information
Secondary ID
ENSG00000138735-PDE5A:NM_001083:15
Average complexity
IR-S
Mappability confidence:
NA
Protein Impact
ORF disruption upon sequence inclusion
No structure available
Features
Disorder rate (Iupred):
C1=0.000 A=NA C2=0.000
Domain overlap (PFAM):
C1:
PF0023314=PDEase_I=FE(12.1=100)
A:
NA
C2:
PF0023314=PDEase_I=FE(13.8=100)
Main Inclusion Isoform:
NA
Other Inclusion Isoforms:
NA
Associated events
Other assemblies
Conservation
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
No suggested primer sequences
R:
No suggested primer sequences
Band lengths:
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Autistic and control brains
- Pre-implantation embryo development
Other AS DBs:
FasterDB (Includes CLIP-seq data)
AS-ALPS (AS-induced ALteration of Protein Structure, links to PINs)
APPRIS (Selection of principal isoform)
DEU primates (Only for human)