HsaINT0167563 @ hg19
Intron Retention
Gene
ENSG00000146872 | TLK2
Description
tousled-like kinase 2 [Source:HGNC Symbol;Acc:11842]
Coordinates
chr17:60650576-60654136:+
Coord C1 exon
chr17:60650576-60650728
Coord A exon
chr17:60650729-60654069
Coord C2 exon
chr17:60654070-60654136
Length
3341 bp
Sequences
Splice sites
5' ss Seq
AACGTATGT
5' ss Score
7.69
3' ss Seq
CTTTTACCACTGTTTTTCAGGTT
3' ss Score
9.9
Exon sequences
Seq C1 exon
GCAACAGGAAAGGATAAATTCACAGAGGGAAGAGATAGAAAGACAACGGAAAATGTTAGCAAAGCGGAAACCTCCTGCCATGGGTCAGGCCCCTCCTGCAACCAATGAGCAGAAACAGCGGAAAAGCAAGACCAATGGAGCTGAAAATGAAAC
Seq A exon
GTATGTTCTTTATTGACGTGAACGCTGAGACACCACACCCTGCCCCCAAATACAAATGTTGATTGTCACCGGCAATAGTTTTAAATTCTTGAGGTCACTCAGGTTTAAACCTTCTTTTCAGTTACATTAATGGATTTGCTCAACTCATATAAATGCCATATAAAATTAATTGATTTTCTTAAACCTGCTCTTTCTTTAGGGCATTTTGAATGAGAGGGAAAAGTAATGTCACTTGACATCATGACTTTTGGCCACTCCTGGTTAACAAATAAGATGTCATTGTACTGAAATGATATTATTGCTTACATGTGGCTGCAGGGTGTGGTACACTAGTATCATCTTATGGGAGTTACCTGGCTGTTATTTCAGACTGAAGAATGCTCTTTACTGGTCAAAAGAGCACTTAGTTAATAGTCACAAACTTAGGATAAGCCCCCCAGAAAGCTGTTATGTTAGAAAAGGACATTGTCCCAATAAGCCACAACTTGATCTCATCAGAATTGTTTCCTGTTCTGGGAATCTAAGGAAAACACCAGTATCTTAAACTGCAGTACAGTCATCTTTTTCTCTGTCACTCAACAATATTTACATAGCTACCATATATAGGAGGAGTAGAAAATTCTAAGCACAAATGCCTGCCTTCTCCATTCTTCTCTTCCTTTCTGTTTAACTGAAAGTAAGTTTCAAGTCCAAAGATAGCTGCAGATAAAAGATATATAACTTATCAACTAATATGTCATTTGCTTTATGTTTTCATATTAGTTCACAAAAACAACACATAATCCACTTCAGGTATAATAATACTTGTATTATATTATTGTTAAAAGTCTGTGGCATCCTAGAAGTGCATCTTCTTTCATTCTAGTGAGAAAGATGGCTTAACACCAATCCTCACCCCATACATATCTGATGTTTTGGGAAGTCTCTTCCTTGATGTTCGTTTAGTAAGTTTATGTTAAATGCTTATTTTATGCTAGGCCCTCTTCTGGGAATACAGAGCTAAAGGATACAGCCCCAGCCTTAGGAGCCCACAGTTTACTTAGGTGAGATGAACAGACGAATAAACTAATAATTACATTAAGTATAGCGATAAAAATGTGCATAATGAACTTGGAAAACATCTTCATTCATATAACTCCAAATTTTGTTGTTGTTGTTTTTTTTTTTTGAGACGAAGTCTCACTCCGTCGCCCAGGCCAGAGTGCAGTGGTGCTATCTCGGCTCACTGAAACCTGTCTTCTGGGTTCAAGCGTTTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCGTGCACCACCATGCCCAGCTAGTTTTTGTATTTTTAGTAGAGATGGAGTTTCTCCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAAATGATCCACCCTCCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGCGAGCTACTGCACCCAGCCCAAATGTTACAAAACTAGAGTCTTGTTTTCCCTTGATTTTAAAGACTAGTCAAGTGCAATAATGAGAATGAGAAGAGGGGAAGAGTATTGAGTCTTAAATATAAAGTATTTTCCTTTCAGCAAGTCCAAGTAGGGGCTCAAATTTGAAAGATTGTCCAGGCTAATTAATCTGACCAATGTTTTCTTTCATGACTCCTGTGTGTATTTTGTGAAGGGACTTTCCCTCTAGTATTATTTGAAAATTATTTAATGCTAATGCACAAAACCATTGGCTTAGGAGTGATAAAGAAAGCATAGGTTGTTTCTTTGCCACAGAAGAATAATTAGAATGCAATCTAGGCTAGTAATGTGTAAGCAATTGCTATCTGGTGTCCTGTGTAAAATCCAATCTGGAAGACTTTCAGTCCAGTTTTTAATTAGAGTATCTGTGACTTGGCTCTTACTTTGACCAGAAGCCAGAAGTAGGCCTCTGGGGTCTTGGAGTGAGCCATATTATCCTTTCTTGGCCCCGAACCTGTTTCAGACAGAGAATTCTTAGCCATCATTTTTAATTTTTCTGTTTTTCGCTGGTGTGGAATGGAGTAATAGATACAGGTATTTCTGCATCTGTAAAGAGATAGCCCTAGTGGGTGAGTTTCTTCTTCTTTCTATTTTTTCTTGAGTTAGACCTCAAAGGCTCTGTTCTGGTTGATAGGATAGATATTTCCCCTTTCTTCTGCTATTTAGAATATATCTAAACAGTGATATCTAAAAATATTAAATATCTATATGCTTCTAGAATGCGAAGAAGGTAGAGATGGAAGAAAAAATAATTCTCACTTGTTCATCTTTTTTTCTTTTATTTTCTTTCTTTCTGTCTTTCTCTCTCTCTCTCTTTCTTTTCTTTTCTTTTCTTTCTTGAGACAGAGCCTTGCTCTGTTGCTTGGGCTGGAGTGCAGTGACATGATTATAGCTCACTATAGCCTCAACCTTCTGGGCTCAAGCAATCCTTCCATCTCAGCCTCCTGAGTAGCTGGGACTACAGGCATGTGCCACCATGCCCAGCTTCTTTCTTCTTTTTTTCACAGAGACAGAGTGTTGCTTTGTTGCCCAGGCTGGTCTCAAACTCCTGGCTCCAAGTCCTTCCCGCTCAGCTTCCCAGAGTACTGGGATTACAGTGAGCCACCAAGCCTGGCCACTTGTTCATTCTTGAGATGTAAGGATGCTGTTGGAGTAGTTGGAACATGAAACACATGACTACCCATCAAGTCAGCCCTTTGAGAGTTGATTTAAATAGCATTTTCAATATTCTTTATATGTTGTCATTTAATAGTCACTCTTTCTTAGATAGGTATTATCACTTGCTGCATTTCAGGAAACTGAGTTAAAGAGGTTAAATTTGCTTGCGCAAGGTCACATGGCCAGTAGCTTAGTAGTGCTTTGAACCCTAGTCCTCAGACTCCAAATCCTAGACTCTAATTTGCTGCTATATCTTTCTCTTTGTTATTACAGTATCAAGGTTTAAGTATTAACAAGAATAATCAAATCCATTGGCTTATTGTTTTGCCCTCTAAAAAATTTTTAGAGAATTTTTGGCTGTCTCTGAATGAGTTTTTATCTTAGTAATATATGGCACAAAACTCATTTCAAAAATAATATAAAAATATGGCTCACTTTTTTTTCTTTTTTATGTTTTGCAAATTAGACTTCTGGCTTTGAAGTTCTTCCCTCACATCACATCTGGTAAATCACAGAAGTTTTCTCTTGTCAGAGGACTACAAGATAACCCATCTTTCAGTCATTTTAACTGAGACTGAAACTGAATATGTCTTATAGTATATTTGAGCATTTCTCTTTAAACAGGCAAACTATGATTTCTAGTAGTTTACTGAAACTTTTACCACTGTTTTTCAG
Seq C2 exon
GTTAACGTTAGCAGAATACCATGAACAAGAAGAAATCTTCAAACTCAGATTAGGTCATCTTAAAAAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSG00000146872-TLK2:NM_006852:12
Average complexity
IR-S
Mappability confidence:
NA
Protein Impact
ORF disruption upon sequence inclusion
No structure available
Features
Disorder rate (Iupred):
C1=0.962 A=NA C2=0.065
Domain overlap (PFAM):
C1:
PF082006=Phage_1_1=PD(81.1=57.7)
A:
NA
C2:
NO
Main Inclusion Isoform:
NA
Other Skipping Isoforms:
Associated events
Other assemblies
Conservation
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
No suggested primer sequences
R:
No suggested primer sequences
Band lengths:
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Autistic and control brains
Other AS DBs:
FasterDB (Includes CLIP-seq data)
AS-ALPS (AS-induced ALteration of Protein Structure, links to PINs)
APPRIS (Selection of principal isoform)
DEU primates (Only for human)