Special

MmuEX0003676 @ mm10

Exon Skipping

Gene
ENSMUSG00000000530 | Acvrl1
Description
activin A receptor, type II-like 1 [Source:MGI Symbol;Acc:MGI:1338946]
Coordinates
chr15:101135298-101136227:+
Coord C1 exon
chr15:101135298-101135543
Coord A exon
chr15:101135749-101135960
Coord C2 exon
chr15:101136128-101136227
Length
212 bp
Sequences
Splice sites
3' ss Seq
CAATGTCCCCCCTTCTCCAGCCA
3' ss Score
6.43
5' ss Seq
GGGGTATGG
5' ss Score
5.84
Exon sequences
Seq C1 exon
GAGACTTGGCGAAGCCTTCCAAGCTGGTGAACTGCACTTGTGAGAGCCCACACTGCAAGAGACCATTCTGCCAGGGGTCATGGTGCACAGTGGTGCTGGTTCGGGAGCAGGGCAGGCACCCCCAGGTCTATCGGGGCTGCGGGAGCCTGAACCAGGAGCTCTGCTTGGGACGTCCCACAGAGTTTCTGAACCATCACTGCTGCTATAGATCCTTCTGCAACCACAACGTGTCTCTGATGCTGGAGG
Seq A exon
CCACCCAAACTCCTTCGGAGGAGCCAGAAGTTGATGCCCATCTGCCTCTGATCCTGGGTCCTGTGCTGGCCTTGCCGGTCCTGGTGGCCCTGGGTGCTCTAGGCTTGTGGCGTGTCCGGCGGAGGCAGGAGAAGCAGCGGGATTTGCACAGTGACCTGGGCGAGTCCAGTCTCATCCTGAAGGCATCTGAACAGGCAGACAGCATGTTGGGG
Seq C2 exon
GACTTCCTGGACAGCGACTGTACTACGGGCAGCGGCTCGGGGCTCCCCTTCTTGGTGCAGAGGACGGTAGCTCGGCAGGTTGCGCTGGTAGAGTGTGTGG
VastDB Features
Vast-tools module Information
Secondary ID
ENSMUSG00000000530-'11-19,'11-17,13-19
Average complexity
S
Mappability confidence:
100%=100=100%
Protein Impact





	

	
ORF disruption upon sequence exclusion





No structure available

		

			
Features


			

				
Disorder rate (Iupred):
  C1=0.000 A=0.070 C2=0.000
 
                        

				
Domain overlap (PFAM):

					





						

							
C1:
PF0106418=Activin_recp=WD(100=86.7),PF032298=Alpha_GJ=PU(15.9=12.0)

							
A:
PF032298=Alpha_GJ=PD(82.5=73.2),PF085157=TGF_beta_GS=PU(10.3=4.2)

							
C2:
PF085157=TGF_beta_GS=PD(82.8=70.6),PF0006920=Pkinase=PU(2.4=20.6)

						

					

				








    
Main Inclusion Isoform:
ENSMUSP00000000542





     
                   









    
Main Skipping Isoform:
NA





     
      









    
Other Inclusion Isoforms:
ENSMUSP00000112490, ENSMUSP00000113297, ENSMUSP00000113505, ENSMUSP00000113536, ENSMUSP00000114027
          









    
Other Skipping Isoforms:
NA
  



Associated events






Other assemblies


mm9




Conservation


Human
(hg38)
chr12:51913559-51913770 
ALTERNATIVE
HsaEX0002218
(ACVRL1)
Human
(hg19)
chr12:52307343-52307554 
ALTERNATIVE
HsaEX0002218
(ACVRL1)
Rat
(rn6)
chr7:142777789-142778000 
HIGH PSI
RnoEX0006484
(Acvrl1)
Cow
(bosTau6)
chr5:28105466-28105677 
HIGH PSI
BtaEX0002324
(ACVRL1)
Chicken
(galGal4)
chrUn_JH375504:9621-9801 
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
chr23:27922048-27922226 
HIGH PSI
DreEX6081195
(acvrl1)
Fruitfly
(dm6)
No conservation detected




Primers PCR

	

		

			
Suggestions for RT-PCR validation

			

				
F: 
CTTCCAAGCTGGTGAACTGCA

				
R: 
TACCGTCCTCTGCACCAAGAA

				
Band lengths: 
300-512

			

		

	





	
Functional annotations
(Submit an annotation)

	


There are 0 annotated functions for this event 


		










GENOMIC CONTEXT[edit]












INCLUSION PATTERN[edit]






SPECIAL DATASETS
  • Pre-implantation embryo development
  • Ribosome-engaged transcriptomes of neuronal types
  • Neural differentiation time course
  • Muscular differentiation time course
  • Spermatogenesis cell types
  • Reprogramming of fibroblasts to iPSCs
  • Hematopoietic precursors and cell types





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