Special

MmuEX0004908 @ mm9

Exon Skipping

Gene
ENSMUSG00000069601 | Ank3
Description
ankyrin 3, epithelial [Source:MGI Symbol;Acc:MGI:88026]
Coordinates
chr10:69476720-69478401:+
Coord C1 exon
chr10:69476720-69476803
Coord A exon
chr10:69476938-69476994
Coord C2 exon
chr10:69478316-69478401
Length
57 bp
Sequences
Splice sites
3' ss Seq
CTCCGTGTTGCTTTCAACAGATC
3' ss Score
10.37
5' ss Seq
GTGGTAATG
5' ss Score
4.46
Exon sequences
Seq C1 exon
GGGGAGGAAGCCAAAAACATCCCTGGTGAATCTGTCACAGAAGAGCAATTTACTGATGAAGAAGGCAACCTCATCACGAGAAAA
Seq A exon
ATCACTCGGAAAGTAATAAGACGGATTGGTCCACAAGAGAGGAAGCAGGATGACGTG
Seq C2 exon
CAGGGAGAAGGCTATAAGGTGAAGACGAAGAAGGAAATCCGGAACGTGGAGAAGAAAACCCACTAGTGACAGTGACGTCAGTCCAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSMUSG00000069601-'54-56,'54-55,55-56
Average complexity
C3
Mappability confidence:
100%=100=100%
Protein Impact





	

	
Alternative protein isoforms (No Ref)





No structure available

		

			
Features


			

				
Disorder rate (Iupred):
  C1=NA A=1.000 C2=0.973
 
                        

				
Domain overlap (PFAM):

					





						

							
C1:
NA

							
A:
NA

							
C2:
NO

						

					

				








    
Main Inclusion Isoform:
NA





     
                   









    
Main Skipping Isoform:
ENSMUSP00000090090f5603A





     
      









    
Other Inclusion Isoforms:
NA
          









    
Other Skipping Isoforms:
NA
  



Associated events






Other assemblies


mm10




Conservation


Human
(hg38)
chr10:60044074-60044133 
ALTERNATIVE
HsaEX0004152
(ANK3)
Human
(hg19)
chr10:61803832-61803891 
ALTERNATIVE
HsaEX0004152
(ANK3)
Rat
(rn6)
chr20:20469867-20469923 
ALTERNATIVE
RnoEX0009390
(Ank3)
Cow
(bosTau6)
chr28:15839246-15839305 
ALTERNATIVE
BtaEX0003427
(ANK3)
Chicken
(galGal4)
chr6:8514383-8514442 
ALTERNATIVE
GgaEX0004070
(chAnk3)
Chicken
(galGal3)
chr6:10176644-10176703 
ALTERNATIVE
GgaEX0004070
(Q90717_CHICK)
Zebrafish
(danRer10)
No conservation detected
Fruitfly
(dm6)
No conservation detected




Primers PCR

	

		

			
Suggestions for RT-PCR validation

			

				
F: 
AGGAAGCCAAAAACATCCCTGG

				
R: 
TCTCCACGTTCCGGATTTCCT

				
Band lengths: 
132-189

			

		

	





	
Functional annotations
(Submit an annotation)

	


There are 1 annotated functions for this event 


PMID: 21223964
MmuEX0004908
Ankyrins-G coimmunoprecipitated with plectin and filamin C from skeletal muscle tissue extracts. Muscle-specific OTBD domain (coordinated inclusion of MmuEX1003810, MmuEX1003809, MmuEX0004908) is required for ankyrin-G binding to plectin and filamin C. Isoforms are differentially expressed during myogenesis.


		










GENOMIC CONTEXT[edit]












INCLUSION PATTERN[edit]






SPECIAL DATASETS
  • Pre-implantation embryo development
  • Neural differentiation time course
  • Muscular differentiation time course
  • Spermatogenesis cell types
  • Reprogramming of fibroblasts to iPSCs
  • Hematopoietic precursors and cell types






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