MmuEX0004908 @ mm10
Exon Skipping
Gene
ENSMUSG00000069601 | Ank3
Description
ankyrin 3, epithelial [Source:MGI Symbol;Acc:MGI:88026]
Coordinates
chr10:70013972-70015653:+
Coord C1 exon
chr10:70013972-70014055
Coord A exon
chr10:70014190-70014246
Coord C2 exon
chr10:70015568-70015653
Length
57 bp
Sequences
Splice sites
3' ss Seq
CTCCGTGTTGCTTTCAACAGATC
3' ss Score
10.37
5' ss Seq
GTGGTAATG
5' ss Score
4.46
Exon sequences
Seq C1 exon
GGGGAGGAAGCCAAAAACATCCCTGGTGAATCTGTCACAGAAGAGCAATTTACTGATGAAGAAGGCAACCTCATCACGAGAAAA
Seq A exon
ATCACTCGGAAAGTAATAAGACGGATTGGTCCACAAGAGAGGAAGCAGGATGACGTG
Seq C2 exon
CAGGGAGAAGGCTATAAGGTGAAGACGAAGAAGGAAATCCGGAACGTGGAGAAGAAAACCCACTAGTGACAGTGACGTCAGTCCAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSMUSG00000069601_MULTIEX2-7/7=6-C2
Average complexity
C3
Mappability confidence:
100%=100=100%
Protein Impact
Alternative protein isoforms (No Ref)
No structure available
Features
Disorder rate (Iupred):
C1=0.934 A=1.000 C2=1.000
Domain overlap (PFAM):
C1:
NO
A:
NO
C2:
NO
Main Skipping Isoform:
ENSMUST00000182992fB5785
Other Inclusion Isoforms:
Other Skipping Isoforms:
NA
Associated events
Other assemblies
Conservation
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
AGGAAGCCAAAAACATCCCTGG
R:
TCTCCACGTTCCGGATTTCCT
Band lengths:
132-189
Functional annotations
There are 1 annotated functions for this event
PMID: 21223964
This event
Ankyrins-G coimmunoprecipitated with plectin and filamin C from skeletal muscle tissue extracts. Muscle-specific OTBD domain (coordinated inclusion of MmuEX1003810, MmuEX1003809, MmuEX0004908) is required for ankyrin-G binding to plectin and filamin C. Isoforms are differentially expressed during myogenesis.
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Pre-implantation embryo development
- Ribosome-engaged transcriptomes of neuronal types
- Neural differentiation time course
- Muscular differentiation time course
- Spermatogenesis cell types
- Reprogramming of fibroblasts to iPSCs
- Hematopoietic precursors and cell types