MmuEX1003810 @ mm10
Exon Skipping
Gene
ENSMUSG00000069601 | Ank3
Description
ankyrin 3, epithelial [Source:MGI Symbol;Acc:MGI:88026]
Coordinates
chr10:70008778-70015653:+
Coord C1 exon
chr10:70008778-70008864
Coord A exon
chr10:70013972-70014055
Coord C2 exon
chr10:70015568-70015653
Length
84 bp
Sequences
Splice sites
3' ss Seq
CTCTATGCTGCATCCTTTAGGGG
3' ss Score
7.36
5' ss Seq
AAAGTAATC
5' ss Score
0.63
Exon sequences
Seq C1 exon
GACTTGAGAAACAGTGAGAGTGATTCAAGCTCAGAGGAGGAGCAGAGGATCACTACCCGGGTCATACGAAGGCGTGTGATTATAAAG
Seq A exon
GGGGAGGAAGCCAAAAACATCCCTGGTGAATCTGTCACAGAAGAGCAATTTACTGATGAAGAAGGCAACCTCATCACGAGAAAA
Seq C2 exon
CAGGGAGAAGGCTATAAGGTGAAGACGAAGAAGGAAATCCGGAACGTGGAGAAGAAAACCCACTAGTGACAGTGACGTCAGTCCAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSMUSG00000069601_MULTIEX2-6/7=5-C2
Average complexity
C3
Mappability confidence:
100%=100=100%
Protein Impact
Alternative protein isoforms (No Ref)
No structure available
Features
Disorder rate (Iupred):
C1=0.872 A=0.934 C2=1.000
Domain overlap (PFAM):
C1:
NO
A:
NO
C2:
NO
Main Skipping Isoform:
ENSMUST00000182992fB5785
Other Inclusion Isoforms:
Other Skipping Isoforms:
NA
Associated events
Conservation
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
GAGAAACAGTGAGAGTGATTCAAGC
R:
TGGACTGACGTCACTGTCACT
Band lengths:
167-251
Functional annotations
There are 1 annotated functions for this event
PMID: 21223964
This event
Ankyrins-G coimmunoprecipitated with plectin and filamin C from skeletal muscle tissue extracts. Muscle-specific OTBD domain (coordinated inclusion of MmuEX1003810, MmuEX1003809, MmuEX0004908) is required for ankyrin-G binding to plectin and filamin C. Isoforms are differentially expressed during myogenesis.
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Ribosome-engaged transcriptomes of neuronal types
- Neural differentiation time course
- Muscular differentiation time course
- Spermatogenesis cell types
- Reprogramming of fibroblasts to iPSCs
- Hematopoietic precursors and cell types