MmuEX1023103 @ mm10
Exon Skipping
Gene
ENSMUSG00000075318 | Scn2a
Description
sodium channel, voltage-gated, type II, alpha [Source:MGI Symbol;Acc:MGI:98248]
Coordinates
chr2:65717388-65726448:+
Coord C1 exon
chr2:65717388-65717867
Coord A exon
chr2:65718938-65719021
Coord C2 exon
chr2:65726328-65726448
Length
84 bp
Sequences
Splice sites
3' ss Seq
ACCATTCTTACTTCTCACAGGGG
3' ss Score
8.26
5' ss Seq
CAGGTTACC
5' ss Score
-1.62
Exon sequences
Seq C1 exon
GTTCTGAACCTCTTCTTGGCCTTGCTCCTCAGTTCTTTCAGCTCGGACAACCTGGCTGCCACAGATGACGATAACGAAATGAACAACCTCCAGATAGCCGTGGGAAGGATGCAGAAGGGGATTGATTTTGTTAAAAGGAAGATACGTGAATTCATTCAGAAAGCCTTTGTCAGAAAGCAGAAAGCTCTAGATGAAATCAAACCCCTTGAAGATCTGAATAACAAGAAAGACAGTTGTATCTCCAACCACACAACCATAGAAATAGGCAAGGACCTGAATTACCTCAAAGATGGAAACGGGACGACCAGTGGCATAGGCAGCAGTGTGGAGAAGTACGTGGTAGATGAGAGTGATTACATGTCATTCATCAACAACCCCAGCCTCACCGTGACTGTGCCCATTGCTGTGGGAGAGTCTGACTTTGAAAACTTAAATACAGAAGAATTCAGCAGTGAATCAGATATGGAAGAAAGCAAGGAG
Seq A exon
GGGTGAGACCAAGCTGGCGCCATCAAGAATGCCGCTCTGGTGTTTTTTAAGCAGCCAGAGGCTCGAGCCATCACTTTTGCCCAG
Seq C2 exon
AAATTGAATGCAACTAGTTCATCTGAAGGCAGTACAGTTGATATAGGTGCTCCTGCAGAGGGAGAGCAACCAGAGGCCGAACCAGAAGAGTCCCTTGAGCCAGAAGCCTGTTTCACAGAAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSMUSG00000075318_CASSETTE2
Average complexity
S*
Mappability confidence:
100%=100=100%
Protein Impact
ORF disruption upon sequence inclusion
No structure available
Features
Disorder rate (Iupred):
C1=0.146 A=1.000 C2=0.780
Domain overlap (PFAM):
C1:
PF0052026=Ion_trans=PD(4.2=5.0),PF065128=Na_trans_assoc=PU(61.3=85.0)
A:
PF065128=Na_trans_assoc=PD(0.1=0.0)
C2:
PF065128=Na_trans_assoc=FE(18.0=100)
Associated events
Conservation
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
TGCTGTGGGAGAGTCTGACTT
R:
TGGCTCAAGGGACTCTTCTGG
Band lengths:
181-265
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Ribosome-engaged transcriptomes of neuronal types
- Neural differentiation time course
- Muscular differentiation time course
- Spermatogenesis cell types
- Reprogramming of fibroblasts to iPSCs
- Hematopoietic precursors and cell types