MmuEX6000467 @ mm10
Exon Skipping
Gene
ENSMUSG00000056632 | Dsg3
Description
desmoglein 3 [Source:MGI Symbol;Acc:MGI:99499]
Coordinates
chr18:20537245-20541310:+
Coord C1 exon
chr18:20537245-20537308
Coord A exon
chr18:20538341-20538561
Coord C2 exon
chr18:20539596-20541310
Length
221 bp
Sequences
Splice sites
3' ss Seq
TTTCTCTCCCCTGTCTTTAGAAG
3' ss Score
9.38
5' ss Seq
CAGGTAACT
5' ss Score
8.63
Exon sequences
Seq C1 exon
GAAATCACAAATATTTGTGTTCCTCCAGTTACAACCAATGGAGCCGATTTTATGGAAAGCTCTG
Seq A exon
AAGTTTGCACAAATACATATGCTGGTGGGACCATGGTAGAAGGTGCTTCAGGAATGGAAATGATTACCAAGCTGGGAGGAGCTACTGGAGCTACAGCGGCACTTGGTCCCTGTTCCTTGGGTTATTCAGGAACAATGAGAACAAGGCATTCCACTGGAGGGACCTTGAAGGACTATGCTGCGCCAGTCAACATGACTTTCCTAGGCTCCTATTTCTCTCAG
Seq C2 exon
AAATCACTCGCCTATGCCGAGGAAGAGGATGAGCGCGAAGTGAACGACTGTTTGCTGATCTACGATGATGAAGGCGAGGATGCTGCCCCCCACTCCCCCACCCTCAGCTCCTGCAGCATTTTTGCCGATGACCTAGACGACAACTTCTTGGATTCCCTTGGCCCCAAATTTAAAAAGCTTGCAGAGATCTGTCTCGGTATTGATGACGAAGCCAAGCAAGCAAAGCCAGGCCCTAAAGACAGTGGTTCTGGGGCTGATACCTGCGCTCGCTCTATGGAAGTCCCTCAGTCAGGTTCTAACAGGTACCAGACTTTGCCTGGCAGTCTGGAAGTCACCCAAACGGGTTCTAAAATATGCCACACGCTGTCAGGCAACCAAGAAACTTCTGTTATGTCCACTTCTGGGTCTGTCCACCCTGCTGTTGCCATCCCTGACCCTCTACAGCTTGGGAACTACTTGCTCACAGAAACTTACTCAACTTCAGGTTCCTTTGCACAACC
VastDB Features
Vast-tools module Information
Secondary ID
ENSMUSG00000056632-'4-16,'4-14,15-16=AN
Average complexity
A_S
Mappability confidence:
NA
Protein Impact
ORF disruption upon sequence exclusion
No structure available
Features
Disorder rate (Iupred):
C1=0.182 A=0.027 C2=0.338
Domain overlap (PFAM):
C1:
NO
A:
PF0104912=Cadherin_C=PU(20.0=23.0)
C2:
PF0104912=Cadherin_C=PD(77.6=30.0)
Main Skipping Isoform:
NA
Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
NA
Associated events
Other assemblies
Conservation
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
CAGTTACAACCAATGGAGCCGA
R:
TATCAGCCCCAGAACCACTGT
Band lengths:
298-519
Functional annotations
There are 1 annotated functions for this event
PMID: 11500511
Encodes an experimentally validated Eukaryotic Linear Motif (ELM). Method: cleavage reaction, confocal microscopy, edman degradation, western blot. ELM ID: ELMI001926; ELM sequence: DYADG; Overlap: FULL
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Ribosome-engaged transcriptomes of neuronal types
- Neural differentiation time course
- Muscular differentiation time course
- Spermatogenesis cell types
- Reprogramming of fibroblasts to iPSCs
- Hematopoietic precursors and cell types