MmuEX6009246 @ mm9
Exon Skipping
Gene
ENSMUSG00000040488 | Ltbp4
Description
latent transforming growth factor beta binding protein 4 [Source:MGI Symbol;Acc:MGI:1321395]
Coordinates
chr7:28094305-28095806:-
Coord C1 exon
chr7:28095540-28095806
Coord A exon
chr7:28095200-28095271
Coord C2 exon
chr7:28094305-28094433
Length
72 bp
Sequences
Splice sites
3' ss Seq
TTCTTTCCTTCTATGTACAGCTG
3' ss Score
9.1
5' ss Seq
GAGGTAAGG
5' ss Score
10.28
Exon sequences
Seq C1 exon
GCACGTTCCCTGGCTCCCAGCCCCAAGCACCTGCCAGCCCCAGTCTTCCAGCCAGGCCACCAGCCCCTCCCCCACCTCGAAGACCCAGCCCTCCCAGGCAGGGTCCCGTGAGCAGTGGACGTCGCGAGTGCTACTTTGATACAGCCGCTCCAGATGCGTGTGACAATATCTTGGCCCGAAACGTGACGTGGCAGGAGTGCTGCTGTACTGTGGGAGAAGGCTGGGGCAGCGGCTGCCGCATCCAACAGTGCCCGGGCACCGAGACAG
Seq A exon
CTGAATACCAGTCATTGTGTCCTCACGGCCGGGGCTACCTGGTGCCCAGTGGAGACCTGAGTGCCCGGAGAG
Seq C2 exon
ATGTGGACGAATGCCAACTCTTCCAGGACCAGGTGTGCAAGAGCGGAGTGTGTGTGAACACGGCCCCAGGCTACTCTTGCTATTGCAGCAACGGGTTCTACTATCACGCACACAGGCTGGAGTGCGTTG
VastDB Features
Vast-tools module Information
Secondary ID
ENSMUSG00000040488-'43-40,'43-39,46-40=AN
Average complexity
A_S
Mappability confidence:
100%=100=100%
Protein Impact
Alternative protein isoforms (Ref)
No structure available
Features
Disorder rate (Iupred):
C1=0.383 A=0.032 C2=0.000
Domain overlap (PFAM):
C1:
PF0068312=TB=PU(86.4=42.2)
A:
PF0068312=TB=PD(11.4=20.0),PF0764510=EGF_CA=PU(0.1=0.0)
C2:
PF0764510=EGF_CA=WD(100=95.5),PF0764510=EGF_CA=PU(0.1=0.0)
Main Skipping Isoform:
NA
Other Inclusion Isoforms:
Other Skipping Isoforms:
NA
Associated events
Other assemblies
Conservation
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
CGTCGCGAGTGCTACTTTGAT
R:
CCTGGAAGAGTTGGCATTCGT
Band lengths:
175-247
Functional annotations
There are 1 annotated functions for this event
PMID: 11683420
LTBP-4delta8-Cys3rd (skipping of both exons) does not bind TGF-beta and it was found to be expressed in the same tissues as the full length LTBP-4
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
Other AS DBs: