Special

MmuEX6039471 @ mm9

Exon Skipping

Gene
ENSMUSG00000025809 | Itgb1
Description
integrin beta 1 (fibronectin receptor beta) [Source:MGI Symbol;Acc:MGI:96610]
Coordinates
chr8:131244175-131246932:+
Coord C1 exon
chr8:131244175-131244374
Coord A exon
chr8:131246284-131246522
Coord C2 exon
chr8:131246710-131246932
Length
239 bp
Sequences
Splice sites
3' ss Seq
GTGTTTGGATCTTTCTGCAGGTG
3' ss Score
10.96
5' ss Seq
GAGGTGGGT
5' ss Score
7.07
Exon sequences
Seq C1 exon
GTTCAATTTGAAATTAGCATAACTGCTAATAAATGTCCAAATAAGGAGTCTGAAACCATTAAAATTAAACCTCTGGGCTTCACTGAAGAAGTAGAGGTCGTTCTTCAGTTCATCTGTAAGTGCAATTGTCAAAGCCATGGCATCCCAGCCAGTCCCAAGTGCCATGAGGGAAATGGGACATTTGAGTGTGGAGCCTGCAG
Seq A exon
GTGCAATGAGGGGCGTGTTGGGAGGCACTGTGAATGTAGCACAGATGAAGTGAACAGTGAAGACATGGACGCTTACTGCAGGAAAGAGAACAGTTCGGAAATCTGCAGTAACAATGGAGAATGTGTCTGTGGACAGTGTGTGTGTAGGAAGAGAGATAATACAAATGAAATTTACTCTGGAAAATTCTGCGAGTGTGATAACTTCAACTGTGATAGGTCTAATGGCTTAATTTGTGGAG
Seq C2 exon
GCAATGGCGTGTGCAGGTGTCGTGTTTGTGAATGCTATCCCAATTACACTGGCAGTGCATGTGACTGTTCTTTGGACACTGGTCCATGTCTAGCGTCAAATGGTCAGATCTGCAATGGCCGGGGTATTTGTGAATGTGGTGCTTGTAAGTGCACAGATCCCAAGTTTCAAGGGCCAACTTGTGAGACATGTCAGACCTGCCTTGGCGTCTGTGCAGAGCATAA
VastDB Features
Vast-tools module Information
Secondary ID
ENSMUSG00000025809-'15-13,'15-12,17-13=AN
Average complexity
A_S
Mappability confidence:
100%=100=100%
Protein Impact





	

	
ORF disruption upon sequence exclusion





No structure available

		

			
Features


			

				
Disorder rate (Iupred):
  C1=0.000 A=0.000 C2=0.000
 
                        

				
Domain overlap (PFAM):

					





						

							
C1:
PF0036213=Integrin_beta=PD(9.3=59.7)

							
A:
PF079748=EGF_2=WD(100=64.4),PF079748=EGF_2=PU(32.3=16.9)

							
C2:
PF079748=EGF_2=PD(64.5=26.7),PF079748=EGF_2=WD(100=42.7),PF079657=Integrin_B_tail=PU(4.5=5.3)

						

					

				








    
Main Inclusion Isoform:
ENSMUSP00000087457





     
                   









    
Main Skipping Isoform:
NA





     
      









    
Other Inclusion Isoforms:
ENSMUSP00000004192
          









    
Other Skipping Isoforms:
NA
  



Associated events






Other assemblies


mm10




Conservation


Human
(hg38)
chr10:32911886-32912124 
ALTERNATIVE
HsaEX6088112
(ITGB1)
Human
(hg19)
chr10:33200814-33201052 
ALTERNATIVE
HsaEX6088112
(ITGB1)
Rat
(rn6)
chr19:61714402-61714640 
HIGH PSI
RnoEX0045175
(Itgb1)
Cow
(bosTau6)
chr13:20281060-20281298 
HIGH PSI
BtaEX6063985
(ITGB1)
Chicken
(galGal4)
chr2:14004212-14004450 
HIGH PSI
GgaEX6018538
(ITGB1)
Chicken
(galGal3)
chr2:13988460-13988698 
HIGH PSI
GgaEX6018538
(F1N8N7_CHICK)
Zebrafish
(danRer10)
chr24:1126414-1126652 
HIGH PSI
DreEX6093681
(itgb1a)
Fruitfly
(dm6)
No conservation detected




Primers PCR

	

		

			
Suggestions for RT-PCR validation

			

				
F: 
ACCTCTGGGCTTCACTGAAGA

				
R: 
TGGCCCTTGAAACTTGGGATC

				
Band lengths: 
308-547

			

		

	





	
Functional annotations
(Submit an annotation)

	


There are 0 annotated functions for this event 


		










GENOMIC CONTEXT[edit]












INCLUSION PATTERN[edit]










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