Special

MmuINT0006492 @ mm9

Intron Retention

Gene
ENSMUSG00000030111 | A2m
Description
alpha-2-macroglobulin [Source:MGI Symbol;Acc:MGI:2449119]
Coordinates
chr6:121628000-121628578:+
Coord C1 exon
chr6:121628000-121628102
Coord A exon
chr6:121628103-121628536
Coord C2 exon
chr6:121628537-121628578
Length
434 bp
Sequences
Splice sites
5' ss Seq
AAGGTGAGC
5' ss Score
9.6
3' ss Seq
CTGTTTTCTCATTTACTCAGATG
3' ss Score
8.78
Exon sequences
Seq C1 exon
GTGTCAAATCAGATGCTGACCTTGTTCTTCATGGTGCAGCAAGATATTCCAGTGAGAGACCTGAAGCCAGCCATAGTGAAAGTCTATGATTACTACGAGAAAG
Seq A exon
GTGAGCAAGAGCATCCTGAACATGGGCATTCAGTTCCCCGTGCAGGAACTCAGACCTAGGAACGTGCCAGGCTGCCAAGTGACACTGGCTCCTCACCACTTCCTCTTGTCTCCTTCAGGTTTGACACCTGCCCCCTTTATCTCCTTGCTTCTGTGGAAGAAAGCACATTTTAAACCCATCAACCAGAAAAACAAAGTAGTTGCAGAGTTAAATTTTTTGTCAGATAAGCCAGTCATAGGACAGGAATGAGATTTAAGAATGTACAACAACCGACTGTCAGGAGTCTGGGGTGAAATGTGGCTCACCATTGCTGGAAGGTTGTCCAAGGCAACAAGCAGTGGATTAGAGAAATGATGTGGGCATTTCTGATGCAAATGCAGAAGCCCATGGTGACATCACTTGATGCATTTGTTTCTGTTTTCTCATTTACTCAG
Seq C2 exon
ATGAGTTTGCAGTTGCAAAATACAGTGCTCCCTGCAGTGCAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSMUSG00000030111-A2m:NM_175628:34
Average complexity
IR-S
Mappability confidence:
NA
Protein Impact





	

	
ORF disruption upon sequence inclusion





No structure available

		

			
Features


			

				
Disorder rate (Iupred):
  C1=0.000 A=NA C2=0.000
 
                        

				
Domain overlap (PFAM):

					





						

							
C1:
PF076779=A2M_recep=FE(38.6=100)

							
A:
NA

							
C2:
PF076779=A2M_recep=PD(8.0=46.7)

						

					

				








    
Main Inclusion Isoform:
NA





     
                   









    
Main Skipping Isoform:
ENSMUSP00000032203





     
      









    
Other Inclusion Isoforms:
NA
          









    
Other Skipping Isoforms:
NA
  



Associated events






Other assemblies


mm10




Conservation


Human
(hg38)
chr12:9068225-9068739 
ALTERNATIVE
HsaINT0000051
(A2M)
Human
(hg19)
chr12:9220821-9221335 
ALTERNATIVE
HsaINT0000051
(A2M)
Rat
(rn6)
chr4:154472121-154472524 
Cow
(bosTau6)
chr5:101345556-101346041 
LOW PSI
BtaINT0010535
(A2M)
Chicken
(galGal4)
chr1:75710473-75710640 
LOW PSI
GgaINT0103712
([1])
Chicken
(galGal3)
chr1:79365851-79366018 
LOW PSI
GgaINT0103712
([2])
Zebrafish
(danRer10)
chr15:21178487-21178602 
ALTERNATIVE
DreINT0000068
(A2ML1 (12 of 13))
Fruitfly
(dm6)
No conservation detected




Primers PCR

	

		

			
Suggestions for RT-PCR validation

			

				
F: 
No suggested primer sequences

				
R: 
No suggested primer sequences

				
Band lengths: 

			

		

	





	
Functional annotations
(Submit an annotation)

	


There are 0 annotated functions for this event 


		










GENOMIC CONTEXT[edit]












INCLUSION PATTERN[edit]






SPECIAL DATASETS
  • Pre-implantation embryo development
  • Muscular differentiation time course
  • Spermatogenesis cell types
  • Reprogramming of fibroblasts to iPSCs
  • Hematopoietic precursors and cell types






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