BtaEX0027493 @ bosTau6
Exon Skipping
Gene
ENSBTAG00000011922 | PLEC
Description
plectin [Source:HGNC Symbol;Acc:HGNC:9069]
Coordinates
chr14:2077669-2088261:+
Coord C1 exon
chr14:2077669-2077767
Coord A exon
chr14:2078571-2081951
Coord C2 exon
chr14:2082049-2088261
Length
3381 bp
Sequences
Splice sites
3' ss Seq
TCTCTCTGCCACGGCCGCAGAGG
3' ss Score
6.17
5' ss Seq
GAGGTATCT
5' ss Score
7.27
Exon sequences
Seq C1 exon
TACGTGGACCTGCGGACTCGCTACAGTGAGTTGAGCACGCTCACCAGCCAGTACATCAGGTTCATCAGTGAGACCCTGCGGCGCATGGAGGAGGAGGAG
Seq A exon
AGGCTGGCCGAGCAGCAGCGAGCGGAGGAGCGGGAGCGGCTGGCTGAGGTGGAGGCTGCACTGGAGAAGCAGCGGCAGCTGGCTGAGGCCCACGCCCAGGCGAAGGCGCAGGCGGAGCGCGAGGCCCAGGAGCTGCAGCGGCGCATGCAGGAGGAGGTGGCACGCCGGGAGGAGGTCGTGGTGGATGCGCAGCAGCAGAAGCGCAGCATCCAGGAGGAGCTGCAGCAGCTGCGGCAGAGCTCGGAGGCGGAGATCCAGGCGAAGGCCCGGCAGGTGGAGGCAGCCGAGCGCAGCCGGCTGCGCATCGAGGAGGAGATCCGAGTGGTGCGCCTGCAGCTGGAGACCACGGAGCGCCAGCGCGGCGGGGCGGAGGGCGAGCTGCAGGCGCTGCGGGCGCGGGCAGAGGAGGCTGAGGCACAGAAGCGGCAGGCCCAGGAGGAAGCAGAACGCCTGCGGCGGCAGGTGCAAGACGAAACCCAGCGCAAGCGGCAGGCTGAGGCTGAGCTGGGCCTGCGTGTGAAGGCGGAGGCCGAGGCGGCAAGGGAGAAGCAGCGGGCCCTGCAGGCGCTAGAGGAGTTACGTCTGCAGGCCGAGGAGGCAGAGCGGCGCCTGCGGCAGGCAGAGGCAGAGCGGGCACGCCAGGTGCAGGTGGCGCTGGAGACAGCACAGCGCAGTGCCCAGGCGGAGCTGCAGAGCAAGCACGCCTCATTTGCTGAGAAGACAGCGCAGCTGGAGCGCACCCTCGAGGAAGAGCACGTGACCGTGGTGCAGCTTCGTGAAGAGGCCACACGCCGGGAGCAGCAGCAGGCGGAGGCCGAGCGTGCCCGCGAAGAGGCCGAGCGTGAGTTGGAGCGCTGGCAGCTGAAGGCCAATGAGGCGCTGAGGCTGCGGCTGCAGGCAGAGGAGGTGGCACAGCAGAAGAGCCTGGCGCAGGCCGAGGCGGAGAAGCAGAAGGAGGCGGCAGAGCGGGAGGCGCGGCGGCGTGGCAAGGCAGAGGAGCAGGCAGTGCGGCAGCGCGAGCTGGCGGAGCAGGAGCTGGAGAGGCAGCGGCAGCTGGCGGAGGGCACTGCGCAGCAGCGCCTGGCCGCCGAGCAGGAGCTGATCCGGCTGCGCGCCGAGACAGAACAAGGTGAGCAGCAGCGGCAGCTGCTGGAGGAGGAGCTGGCTCGGCTACAGAGCGAGGCGGCTGCCGCCACGCAGAAGCGCCAGGAGCTGGAGGCTGAGCTGGCCAAGGTGCGGGCTGAGATGGAGGTGCTGCTGGCCAGCAAGGCGCGGGCCGAGGAGGAATCGCGCTCCAGCAGCGAGAAGTCCAAGCAGAGGCTGGAAGCCGAGGCCGGGCGCTTCCGCGAGCTGGCAGAGGAGGCTGCCCGCCTGCGCGCGCTGGCGGAGGAGGCCAAGCGGCAGCGGCAGCTGGCGGAGGAGGATGCGGCGCGGCAGCGGGCAGAGGCTGAGCGGGTGCTGTCCGAGAAGCTGGCTGCCATCAGCGAGGCCACGCGGCTCAAGACGGAGGCAGAGATCGCACTTAAGGAGAAAGAAGCCGAGAACGAGCGCCTGCGGCGGCTGGCGGAAGACGAAGCCTTCCAGCGGCGGAGGCTGGAGGAGCAGGCAGCCCAGCACAAGGCCGACATCGAGGAGCGGCTGGCACAGCTGCGTAAGGCATCTGAGAGCGAACTGGAGCGGCAGAAGGGGCTGGTGGAGGACACTCTGCGGCAGCGGCGGCAGGTGGAGGAGGAGATCCTGGCCCTTAAGGCAAGCTTCGAGAAGGCAGCCGCCGGCAAGGCGGAGCTGGAATTGGAGCTGGGGCGCATCCGCGGCAACGCAGAGGACACGCTGCGCAGCAAGGAGCAGGCGGAGCAGGAGGCGGCGCGGCAGCGGCAGCTGGCCGCAGAGGAGGAGCGGCGGCGCCGGGAGGCCGAGGAGCGTGTGCAGAAGAGTCTGGCAGCTGAGGAGGAGGCTGCGCGGCAGCGGAAGGCTGCGCTGGAGGAGGTGGAGCGGCTCAAGGCCAAGGTGGAGGAAGCGCGGCGCCTGCGCGAGCGCGCGGAGCAAGAGTCTGCGCGGCAGCTGCAGCTGGCGCAGGAGGCTGCCCAGAAGCGGCTGCAGGCGGAAGAGAAGGCGCATGCCTTTGCAGTGCAGCAGAAGGAGCAGGAGCTGCAGCAGACCCTCCAGCAAGAGCAGAGCATGCTGGAGAGGCTCCGTGGCGAGGCCGAGGCTGCCCGGCGTGCGGCGGAGGAGGCAGAGGAGGCGCGCGAGCGGGCCGAGGGCGAGGCAGCGCAGTCCCGACAGCGCGTGGAGGAGGCGGAGCGGCTGAAGCAGGCGGCGGAGGAGCAGGCGCAGGCTCAGGCGCAGGCGCAGGCCGCCGCAGAGAAGCTGCGCAAGGAAGCTGAACAAGAGGCGGCGCGGCGGGCGCAGGCAGAGCAGGCGGCCCTGCGGCAGAAGCAGGCGGCCGATGCGGAGATGGAGAAACACAAGAAATTCGCGGAGCAGACACTGCGGCAGAAGGCCCAGGTGGAGCAGGAGCTGACGGCACTGCGGTTGAAGCTGGAGGAGACGGACCACCAGAAAAGCATCCTGGACCAGGAGCTGCAGCGGCTGAAGGCGGAGGTGACCGAGGCCGCCCGCCAGCGCAGCCAGGTAGAGGAGGAGCTATTCTCCGTGCGCGTCCAGATGGAGGAGCTCGGCAAGCTCAAGGCTCGCATCGAGGCGGAGAACCGCGCCCTTATTCTGCGCGACAAGGACAACACGCAGCGCCTCCTGCAGGAGGAGGCCGAGAAGATGAAGCAGGTGGCGGAGGAGGCCGCGCGGCTGAGCGTGGCGGCTCAGGAGGCAGCACGGCTGCGTCAGCTGGCGGAGGAGGACCTGGCTCAGCAGCGGGCCCTGGCGGAGAAGATGCTCAAGGAGAAGATGCAGGCAGTACAGGAGGCCACGCGGCTCAAGGCCGAGGCGGAGCTGCTGCAGCAGCAGAAGGAGCTGGCCCAGGAGCAGGCCCGCCGGCTGCAGGAGGACAAGGAGCAGATGGCCCAGCAGCTGGCACAGGAGACGCAAGGCTTCCAGCGGACCCTGGAGACTGAGCGGCAGCGGCAGCTGGAAATGAGCGCGGAGGCCGAGCGGCTCAGGCTGCGTGTGGCTGAGATGAGCCGGGCCCAGGCTCGCGCGGAGGAGGACGCCCAGCGCTTCCGGAAGCAGGCGGAGGAGATTAGCGCAAAGCTGCACCGCACAGAGCTCGCCACGCAGGAGAAGGTGACGCTGGTGCAGACGCTGGAGACACAGCGGCAGCAGAGCGACCGGGATGCCGATCGCCTGAGGGAGGCCATTGCGGAGCTCGAGCGCGAGAAGGACAAGCTCAAGAAGGAGGCTGAGCTGTTGCAGCTCAAGTCTGAGGAG
Seq C2 exon
ATGCAGACGGTGCAGCAGGAGCAACTGCTGCAGGAGACGCAGGCCTTGCAGCAGAGCTTTCTCTCCGAGAAGGACAGCCTGCTGCAGCGGGAGCGCTTCATTGAGGAGGAGAAGGCCAAGCTGGAGAGGCTCTTCCAGGACGAGGTGGCCAAGGCACAGAAGTTGCGGGAGGAGCAGCAGCGACAGCAGCAGCAGATGCAGCAGGAGAAGCAGCAGCTGCTGGCCAGCATGGAGGAGGCGCGGCGGCGGCAGCGTGAGGCTGAGGAGGGTGTGCGGCGCAAGCAGGAGGAGCTGCAGCTCCTGGAGCAGCAGCGGCAGCAGCAGGAGCAGCTGCTGGCGGAGGAAAACCGCCGGCTGCGTGAGCGGCTGGAGCACCTGGAGGAGGAGCATCGGGCCGCACTGGCCCACTCCGAGGAGATCACCGCTGCTCAGGCAGCGGCCACCAGAGCCCTCCCCAACGGCCAGGATGCGACCGACGGCCCAGCTGCAGAGCCAGAGCA
VastDB Features
Vast-tools module Information
Secondary ID
ENSBTAG00000011922_MULTIEX1-2/2=1-C2
Average complexity
S
Mappability confidence:
100%=100=100%
Protein Impact
Alternative protein isoforms (Ref)
No structure available
Features
Disorder rate (Iupred):
C1=0.053 A=0.630 C2=0.158
Domain overlap (PFAM):
C1:
PF0043516=Spectrin=PD(14.7=57.6)
A:
NO
C2:
PF0068115=Plectin=WD(100=2.1),PF0068115=Plectin=WD(100=2.1),PF0068115=Plectin=WD(100=2.2),PF0068115=Plectin=WD(100=2.2),PF0068115=Plectin=WD(100=2.2),PF0068115=Plectin=WD(100=2.2),PF0068115=Plectin=WD(100=2.0),PF0068115=Plectin=WD(100=2.2),PF0068115=Plectin=WD(100=2.2),PF0068115=Plectin=WD(100=2.1),PF0068115=Plectin=WD(100=2.2),PF0068115=Plectin=WD(100=2.2),PF0068115=Plectin=WD(100=1.8),PF0068115=Plectin=WD(100=2.2),PF0068115=Plectin=WD(100=2.2),PF0068115=Plectin=WD(100=1.7),PF0068115=Plectin=WD(100=1.5),PF0068115=Plectin=WD(100=2.2),PF0068115=Plectin=WD(100=2.2)
Main Skipping Isoform:
NA
Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
NA
Associated events
Conservation
Chicken
(galGal3)
No conservation detected
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
No suggested primer sequences
R:
No suggested primer sequences
Band lengths:
Functional annotations
There are 1 annotated functions for this event
PMID: 33986153
SNRPA1 enhances metastatic lung colonization and cancer cell invasion, in part through SNRPA1-mediated regulation of PLEC alternative splicing, which can be counteracted by splicing modulating morpholinos.
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Pre-implantation embryo development