MmuEX0035674 @ mm10
Exon Skipping
Gene
ENSMUSG00000022565 | Plec
Description
plectin [Source:MGI Symbol;Acc:MGI:1277961]
Coordinates
chr15:76170974-76179913:-
Coord C1 exon
chr15:76179659-76179913
Coord A exon
chr15:76178519-76178665
Coord C2 exon
chr15:76170974-76178385
Length
147 bp
Sequences
Splice sites
3' ss Seq
CTGAACTTGCGACACAGGAGAAG
3' ss Score
-14.76
5' ss Seq
GAGGTACCG
5' ss Score
8.5
Exon sequences
Seq C1 exon
GTCGAGCGACTCAAGGCCAAGGTTGAAGAAGCACGGCGCCTGCGAGAGCGGGCAGAGCAGGAGTCGGCCAGGCAGCTGCAGCTGGCCCAGGAGGCCGCCCAGAAACGGCTGCAGGCGGAGGAGAAGGCACACGCCTTTGTGGTGCAGCAGCGAGAGGAGGAGCTGCAGCAGACGCTTCAGCAAGAGCAGAACATGCTGGATCGGCTGCGGAGTGAGGCAGAGGCAGCGAGGCGAGCCGCCGAGGAGGCGGAGGAG
Seq A exon
AAGGTGACGTTGGTGCAGACGCTGGAGATCCAGCGACAGCAGAGTGACCACGATGCCGAGCGTCTGAGGGAGGCCATTGCGGAGCTGGAGCGTGAGAAGGAGAAGCTCAAGCAGGAGGCGAAGTTACTGCAGCTCAAGTCGGAGGAG
Seq C2 exon
ATGCAGACTGTGCAGCAGGAGCAGATACTGCAGGAGACCCAGGCCCTGCAGAAGAGCTTCCTCTCTGAGAAGGACAGCCTGCTGCAGCGCGAGCGCTTCATCGAGCAGGAGAAGGCCAAGCTGGAGCAGCTCTTCCAGGACGAGGTGGCTAAAGCAAAGCAGCTGCGTGAGGAGCAGCAGCGGCAGCAGCAGCAGATGGAACAGGAAAAGCAGGAGCTGATGGCCAGCATGGAGGAGGCCAGGAGGCGGCAGCGCGAGGCTGAGGAGGGCGTGAGGCGCAAGCAAGAGGAACTGCAGCATCTGGAGCAGCAGCGGCAGCAGCAGGAGAAGCTCCTGGCGGAGGAAAACCAGCGGCTGCGAGAGCGGCTGCAGCGCCTGGAGGAAGAGCACCGCGCTGCCTTGGCTCACTCTGAGATCGCCACCACCCAGGCCGCTTCCACGAAGGCACTGCCCAACGGCCGGGATGCACCCGATGGCCCGTCCGTGGAGGCTGAACCCGA
VastDB Features
Vast-tools module Information
Secondary ID
ENSMUSG00000022565-'71-89,'71-88,72-89
Average complexity
C1*
Mappability confidence:
100%=100=100%
Protein Impact
Alternative protein isoforms (Ref)
No structure available
Features
Disorder rate (Iupred):
C1=NA A=0.644 C2=0.160
Domain overlap (PFAM):
C1:
NA
A:
NO
C2:
PF0068115=Plectin=WD(100=2.2),PF0068115=Plectin=WD(100=2.2),PF0068115=Plectin=WD(100=2.2),PF0068115=Plectin=WD(100=2.1),PF0068115=Plectin=WD(100=2.2),PF0068115=Plectin=WD(100=2.2),PF0068115=Plectin=WD(100=2.1),PF0068115=Plectin=WD(100=2.2),PF0068115=Plectin=WD(100=2.2),PF0068115=Plectin=WD(100=2.1),PF0068115=Plectin=WD(100=2.2),PF0068115=Plectin=WD(100=2.2),PF0068115=Plectin=WD(100=1.8),PF0068115=Plectin=WD(100=2.2),PF0068115=Plectin=WD(100=2.2),PF0068115=Plectin=WD(100=1.7),PF0068115=Plectin=WD(100=1.5),PF0068115=Plectin=WD(100=2.2),PF0068115=Plectin=WD(100=2.2)
Main Skipping Isoform:
ENSMUST00000165210fB14781
Other Inclusion Isoforms:
Other Skipping Isoforms:
NA
Associated events
Other assemblies
Conservation
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
GACGCTTCAGCAAGAGCAGAA
R:
CACGCAGCTGCTTTGCTTTAG
Band lengths:
254-401
Functional annotations
There are 1 annotated functions for this event
PMID: 33986153
SNRPA1 enhances metastatic lung colonization and cancer cell invasion, in part through SNRPA1-mediated regulation of PLEC alternative splicing, which can be counteracted by splicing modulating morpholinos.
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Pre-implantation embryo development
- Ribosome-engaged transcriptomes of neuronal types
- Neural differentiation time course
- Muscular differentiation time course
- Spermatogenesis cell types
- Reprogramming of fibroblasts to iPSCs
- Hematopoietic precursors and cell types