Special

MmuEX0035674 @ mm9

Exon Skipping

Gene
ENSMUSG00000022565 | Plec
Description
plectin [Source:MGI Symbol;Acc:MGI:1277961]
Coordinates
chr15:76001404-76013438:-
Coord C1 exon
chr15:76013340-76013438
Coord A exon
chr15:76008949-76012329
Coord C2 exon
chr15:76001404-76008815
Length
3381 bp
Sequences
Splice sites
3' ss Seq
CCTCTCTGCTGCCGCCACAGCGG
3' ss Score
6.1
5' ss Seq
GAGGTACCG
5' ss Score
8.5
Exon sequences
Seq C1 exon
TACGTGGATCTGCGCACGCGCTACAGCGAGCTGACCACGCTCACGAGCCAGTATATCAAGTTCATCAGTGAGACCCTTCGCCGCATGGAAGAGGAGGAG
Seq A exon
CGGCTGGCTGAGCAACAGCGGGCAGAGGAGCGGGAGCGACTGGCCGAGGTGGAGGCTGCGCTGGAGAAGCAGCGGCAGCTAGCTGAGGCACACGCCCAGGCTAAGGCCCAGGCAGAGCTGGAAGCACAAGAACTGCAGCGGCGCATGCAGGAGGAGGTGGCGCGGCGCGAGGAGGCAGCAGTGGACGCACAGCAGCAGAAGCGCAGCATCCAAGAGGAGCTGCAGCACCTGAGGCAGAGCTCGGAGGCAGAGATCCAGGCCAAGGCCCAGCAGGTGGAGGCTGCAGAACGCAGCCGGATGCGCATTGAGGAAGAGATCCGTGTAGTACGTCTGCAGCTGGAGACAACTGAGCGGCAGCGTGGAGGGGCGGAGGGCGAGCTGCAGGCTCTGCGCGCTCGGGCTGAGGAGGCAGAAGCGCAGAAGCGGCAGGCTCAGGAGGAAGCTGAACGCTTGCGAAGGCAGGTGCAGGATGAGAGCCAGCGCAAACGGCAGGCAGAGGCAGAGCTGGCCCTGCGTGTGAAGGCTGAAGCTGAGGCAGCGCGAGAGAAGCAGAGGGCCCTGCAGGCCCTGGATGAGCTGAGACTGCAGGCCGAGGAGGCCGAGCGGCGGCTGCGCCAAGCCGAGGCAGAGCGGGCACGCCAAGTGCAGGTGGCCCTGGAGACGGCACAGCGCAGTGCGGAAGTGGAGCTGCAGAGCAAGCGGGCATCCTTTGCAGAGAAGACCGCACAATTGGAGCGCACTCTGCAGGAGGAGCATGTAACAGTGGCCCAGCTGCGGGAGGAGGCCGAGCGACGGGCACAGCAGCAAGCTGAGGCTGAGCGAGCCCGGGAGGAAGCTGAGCGGGAGCTGGAGCGCTGGCAGCTGAAGGCCAATGAAGCACTGCGGCTGCGGCTGCAGGCAGAAGAGGTGGCACAGCAGAAGAGCCTGGCACAGGCCGATGCCGAGAAGCAGAAGGAAGAGGCCGAGCGGGAAGCGCGGCGGCGGGGCAAGGCGGAGGAGCAGGCTGTGCGGCAGCGGGAGCTGGCGGAGCAGGAGCTGGAGAAGCAGCGGCAGCTGGCGGAGGGCACCGCACAGCAGCGCCTGGCTGCGGAGCAAGAGCTGATCCGCCTGCGGGCCGAGACAGAGCAAGGTGAGCAGCAGCGGCAGCTGCTGGAGGAAGAGCTGGCCCGGCTACAGCACGAGGCCACCGCAGCCACGCAGAAGCGCCAGGAGCTGGAGGCTGAACTGGCTAAGGTCCGGGCAGAGATGGAGGTACTTCTGGCCAGCAAGGCGCGAGCCGAGGAAGAGTCTCGCTCTACCAGCGAAAAGTCTAAGCAGAGGCTAGAGGCTGAGGCAGGCCGCTTTCGGGAACTGGCCGAGGAGGCTGCCCGGCTGCGTGCTCTGGCGGAGGAGGCCAAGAGGCAGAGGCAGTTGGCAGAGGAGGATGCCGCCCGCCAGCGGGCCGAGGCAGAGCGGGTGCTTACTGAGAAGCTGGCTGCCATCAGTGAGGCCACACGGCTCAAGACGGAGGCAGAGATTGCACTCAAAGAGAAGGAGGCCGAGAATGAGCGCCTGAGGCGCCTGGCAGAAGACGAGGCCTTCCAGCGGCGGCGTCTGGAGGAGCAGGCGGCACTGCACAAGGCTGACATCGAGGAGCGCCTGGCCCAGCTGCGCAAGGCATCAGAGAGCGAGCTGGAGCGGCAGAAGGGCTTGGTGGAGGACACCCTGCGACAGCGGCGGCAGGTGGAGGAGGAGATCATGGCGCTGAAGGTGAGCTTTGAGAAAGCCGCCGCGGGCAAGGCAGAGCTGGAGCTGGAGCTGGGGCGCATTCGCAGCAACGCGGAGGACACAATGCGCAGCAAGGAGCAGGCGGAACTGGAGGCGGCCCGGCAGCGGCAGTTGGCGGCAGAGGAGGAGCAGAGGCGCCGGGAGGCCGAGGAGCGCGTGCAGAGGAGCCTGGCAGCGGAGGAGGAAGCCGCTCGGCAGCGCAAGGTGGCACTGGAGGAGGTCGAGCGACTCAAGGCCAAGGTTGAAGAAGCACGGCGCCTGCGAGAGCGGGCAGAGCAGGAGTCGGCCAGGCAGCTGCAGCTGGCCCAGGAGGCCGCCCAGAAACGGCTGCAGGCGGAGGAGAAGGCACACGCCTTTGTGGTGCAGCAGCGAGAGGAGGAGCTGCAGCAGACGCTTCAGCAAGAGCAGAACATGCTGGATCGGCTGCGGAGTGAGGCAGAGGCAGCGAGGCGAGCCGCCGAGGAGGCGGAGGAGGCCCGGGAGCAGGCGGAGCGCGAGGCAGCGCAGTCTCGGAAACAAGTGGAAGAGGCCGAGCGGCTGAAACAGTCAGCAGAGGAGCAGGCTCAGGCCCAGGCTCAGGCGCAGGCGGCCGCAGAGAAGCTGCGCAAGGAAGCGGAGCAGGAGGCGGCGCGTCGGGCCCAGGCAGAGCAGGCAGCGCTGAAACAGAAGCAGGCAGCCGACGCGGAGATGGAGAAGCATAAAAAGTTTGCAGAGCAGACACTCCGGCAGAAGGCCCAGGTAGAGCAGGAGCTGACCACACTGAGGCTGCAGCTAGAGGAGACTGACCACCAGAAGAGCATCCTGGATGAGGAGCTGCAGCGACTAAAGGCCGAGGTAACAGAGGCAGCCCGGCAGCGCAGCCAGGTAGAGGAGGAGCTCTTCTCTGTCCGTGTGCAGATGGAGGAGCTGGGCAAGCTCAAGGCTCGCATTGAAGCTGAAAACCGGGCCCTCATCCTTCGTGACAAGGACAACACACAGCGCTTCCTGGAGGAGGAGGCCGAGAAGATGAAACAGGTGGCCGAGGAAGCGGCACGGTTGAGCGTGGCCGCCCAGGAGGCAGCACGGCTGAGGCAGCTAGCGGAGGAGGACCTGGCGCAGCAGCGGGCCCTGGCAGAGAAGATGCTGAAGGAGAAGATGCAGGCGGTGCAGGAAGCCACGAGGCTCAAGGCCGAGGCTGAGCTGCTGCAGCAGCAGAAGGAGCTTGCCCAGGAGCAGGCCCGGCGGCTGCAGGAGGACAAGGAGCAAATGGCTCAGCAGTTGGTAGAGGAGACACAGGGTTTCCAGAGGACTCTGGAGGCCGAGCGGCAGCGGCAGCTGGAGATGAGCGCGGAGGCCGAGCGCCTCAAGCTGCGCATGGCTGAGATGAGCCGGGCTCAGGCCCGCGCGGAGGAGGACGCCCAGCGCTTCCGGAAGCAGGCTGAAGAGATCGGCGAGAAGCTGCACCGCACTGAACTTGCGACACAGGAGAAGGTGACGTTGGTGCAGACGCTGGAGATCCAGCGACAGCAGAGTGACCACGATGCCGAGCGTCTGAGGGAGGCCATTGCGGAGCTGGAGCGTGAGAAGGAGAAGCTCAAGCAGGAGGCGAAGTTACTGCAGCTCAAGTCGGAGGAG
Seq C2 exon
ATGCAGACTGTGCAGCAGGAGCAGATACTGCAGGAGACCCAGGCCCTGCAGAAGAGCTTCCTCTCTGAGAAGGACAGCCTGCTGCAGCGCGAGCGCTTCATCGAGCAGGAGAAGGCCAAGCTGGAGCAGCTCTTCCAGGACGAGGTGGCTAAAGCAAAGCAGCTGCGTGAGGAGCAGCAGCGGCAGCAGCAGCAGATGGAACAGGAAAAGCAGGAGCTGATGGCCAGCATGGAGGAGGCCAGGAGGCGGCAGCGCGAGGCTGAGGAGGGCGTGAGGCGCAAGCAAGAGGAACTGCAGCATCTGGAGCAGCAGCGGCAGCAGCAGGAGAAGCTCCTGGCGGAGGAAAACCAGCGGCTGCGAGAGCGGCTGCAGCGCCTGGAGGAAGAGCACCGCGCTGCCTTGGCTCACTCTGAGATCGCCACCACCCAGGCCGCTTCCACGAAGGCACTGCCCAACGGCCGGGATGCACCCGATGGCCCGTCCGTGGAGGCTGAACCCGA
VastDB Features
Vast-tools module Information
Secondary ID
ENSMUSG00000022565_CASSETTE1
Average complexity
S
Mappability confidence:
100%=100=100%
Protein Impact





	

	
Alternative protein isoforms (Ref)





No structure available

		

			
Features


			

				
Disorder rate (Iupred):
  C1=0.062 A=0.644 C2=0.159
 
                        

				
Domain overlap (PFAM):

					





						

							
C1:
NO

							
A:
NO

							
C2:
PF0068115=Plectin=WD(100=2.2),PF0068115=Plectin=WD(100=2.2),PF0068115=Plectin=WD(100=2.2),PF0068115=Plectin=WD(100=2.1),PF0068115=Plectin=WD(100=2.2),PF0068115=Plectin=WD(100=2.2),PF0068115=Plectin=WD(100=2.1),PF0068115=Plectin=WD(100=2.2),PF0068115=Plectin=WD(100=2.2),PF0068115=Plectin=WD(100=2.1),PF0068115=Plectin=WD(100=2.2),PF0068115=Plectin=WD(100=2.2),PF0068115=Plectin=WD(100=1.8),PF0068115=Plectin=WD(100=2.2),PF0068115=Plectin=WD(100=2.2),PF0068115=Plectin=WD(100=1.7),PF0068115=Plectin=WD(100=1.5),PF0068115=Plectin=WD(100=2.2),PF0068115=Plectin=WD(100=2.2)

						

					

				








    
Main Inclusion Isoform:
ENSMUSP00000073124





     
                   









    
Main Skipping Isoform:
ENSMUSP00000130048





     
      









    
Other Inclusion Isoforms:
ENSMUSP00000023226, ENSMUSP00000057158, ENSMUSP00000071765, ENSMUSP00000072478, ENSMUSP00000073124f1277A, ENSMUSP00000074383, ENSMUSP00000075693, ENSMUSP00000075772, ENSMUSP00000079668, ENSMUSP00000087037, ENSMUSP00000126068, ENSMUSP00000126526, ENSMUSP00000127261, ENSMUSP00000129543
          









    
Other Skipping Isoforms:
NA
  



Associated events






Other assemblies


mm10




Conservation


Human
(hg38)
chr8:143925612-143925884 
ALTERNATIVE
HsaEX6082848
(PLEC)
Human
(hg19)
chr8:144996672-145000052 
ALTERNATIVE
HsaEX6082848
(PLEC)
Rat
(rn6)
chr7:117237837-117241217 
HIGH PSI
RnoEX0066906
(Plec)
Cow
(bosTau6)
chr14:2078571-2081951 
ALTERNATIVE
BtaEX0027493
(PLEC)
Chicken
(galGal4)
chr10:19570852-19572630 
Chicken
(galGal3)
chr25:870842-878811 
Zebrafish
(danRer10)
chr19:22833679-22835168 
ALTERNATIVE
DreEX0056143
(pleca)
Fruitfly
(dm6)
No conservation detected




Primers PCR

	

		

			
Suggestions for RT-PCR validation

			

				
F: 
No suggested primer sequences

				
R: 
No suggested primer sequences

				
Band lengths: 

			

		

	





	
Functional annotations
(Submit an annotation)

	


There are 1 annotated functions for this event 


PMID: 33986153
HsaEX1046218
SNRPA1 enhances metastatic lung colonization and cancer cell invasion, in part through SNRPA1-mediated regulation of PLEC alternative splicing, which can be counteracted by splicing modulating morpholinos.


		










GENOMIC CONTEXT[edit]












INCLUSION PATTERN[edit]






SPECIAL DATASETS
  • Pre-implantation embryo development
  • Neural differentiation time course
  • Muscular differentiation time course
  • Spermatogenesis cell types
  • Reprogramming of fibroblasts to iPSCs
  • Hematopoietic precursors and cell types






Retrieved from "https://vastdb.crg.eu/wiki/Special:VastDB"