BtaEX6082445 @ bosTau6
Exon Skipping
Gene
ENSBTAG00000004757 | LTBP4
Description
latent transforming growth factor beta binding protein 4 [Source:HGNC Symbol;Acc:HGNC:6717]
Coordinates
chr18:50193269-50195124:+
Coord C1 exon
chr18:50193269-50193415
Coord A exon
chr18:50194473-50194739
Coord C2 exon
chr18:50195053-50195124
Length
267 bp
Sequences
Splice sites
3' ss Seq
AAAGCCCCTTGTCTCCCCAGGTA
3' ss Score
9.59
5' ss Seq
CAGGTGGGC
5' ss Score
8.07
Exon sequences
Seq C1 exon
ATGTGAATGAATGTGAGACACTACAGGGCGTGTGTGGAGCTGCCCTGTGTGAGAATGTGGAAGGCTCCTTCCTCTGTGTCTGCCCCAACAGCCCTGAGGAGTTTGACCCTATGACCGGGCGCTGTGTTTCCCCTCGGACCTCTGCTG
Seq A exon
GTACATTCCCAGGCGCACAGCCCCACGCACCTGCCAGCCCCAGTCTGCCAGCCAGACCCCCGCCCCCACCCCCGCCCCGCCGGCCCAGCCCACCCAGGCAGGGCCCTGTGAGCAGCGGGCGCCGAGAGTGCTACTTTGACACCGCGGCTCCGGATGCCTGTGACAACATCCTGGCCCGGAACGTGACGTGGCAGGAGTGCTGCTGCACTGTGGGTGAGGGCTGGGGCAGCGGCTGCCGCATCCAGCAGTGCCCGAGCACCGAGACAG
Seq C2 exon
CTGAGTACCAGTCATTGTGCCCCCATGGCCGGGGCTACCTGGCGCCCAGCGGAGATCTGAGTCTCAGGAGAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSBTAG00000004757-'40-45,'40-43,42-45=AN
Average complexity
A_S
Mappability confidence:
100%=100=100%
Protein Impact
Alternative protein isoforms (Ref)
No structure available
Features
Disorder rate (Iupred):
C1=0.080 A=0.390 C2=0.301
Domain overlap (PFAM):
C1:
PF0764510=EGF_CA=WD(100=84.0)
A:
PF0068312=TB=PU(86.4=42.2)
C2:
PF0068312=TB=PD(11.4=20.0)
Main Skipping Isoform:
NA
Other Skipping Isoforms:
NA
Associated events
Conservation
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
TGTGAATGAATGTGAGACACTACAGG
R:
TGAGACTCAGATCTCCGCTGG
Band lengths:
212-479
Functional annotations
There are 1 annotated functions for this event
PMID: 11683420
LTBP-4delta8-Cys3rd (skipping of both exons) does not bind TGF-beta and it was found to be expressed in the same tissues as the full length LTBP-4
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]