RnoEX0051407 @ rn6
Exon Skipping
Gene
ENSRNOG00000020871 | Ltbp4
Description
latent transforming growth factor beta binding protein 4 [Source:RGD Symbol;Acc:1307033]
Coordinates
chr1:84122959-84127370:-
Coord C1 exon
chr1:84127224-84127370
Coord A exon
chr1:84123306-84123572
Coord C2 exon
chr1:84122959-84123030
Length
267 bp
Sequences
Splice sites
3' ss Seq
AAAGTCTTTTGTTTCTTCAGGCA
3' ss Score
7.82
5' ss Seq
CAGGTGGGC
5' ss Score
8.07
Exon sequences
Seq C1 exon
ATGTGAATGAGTGTGAGACACTACAGGGTGTCTGTGGCTCCGCACTGTGTGAAAATGTTGAGGGCTCCTTCCTGTGTGTCTGCCCCACCAGCCCTGAGGAGTTCGATCCCATGACTGGACGTTGTGTTCCCCCTCGGACTCCTGCAG
Seq A exon
GCACGTTCCCAGGCTCGCAGCCCCAAGCACCTGCCAGCCCCAGTCTTCCAGCCAGGCCTCCCGCCCCTCCCCCACCTCGAAGACCCAGTCCTCCCAGGCAGGGTCCCGTGAGCAGTGGGCGTCGTGAGTGCTACTTTGACACGGCAGCTCCAGATGCGTGTGACAATATCTTGGCTCGTAACGTGACGTGGCAGGAGTGCTGCTGTACTGTGGGAGAAGGCTGGGGCAGCGGGTGCCGCATCCAGCAGTGCCCGGGCACGGAGACAG
Seq C2 exon
CTGAATACCAGTCATTGTGTCCTCACGGCCGGGGCTACCTAGTGCCCAGTGGAGACCTGAGTGCCCGGAGAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSRNOG00000020871-'38-34,'38-33,39-34
Average complexity
S
Mappability confidence:
100%=100=100%
Protein Impact
Alternative protein isoforms (Ref)
No structure available
Features
Disorder rate (Iupred):
C1=0.220 A=0.400 C2=0.040
Domain overlap (PFAM):
C1:
PF0764510=EGF_CA=WD(100=84.0)
A:
PF0068312=TB=PU(86.4=42.2)
C2:
PF0068312=TB=PD(11.4=20.0),PF0764510=EGF_CA=PU(0.1=0.0)
Main Skipping Isoform:
NA
Other Skipping Isoforms:
NA
Associated events
Conservation
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
GTGTGAGACACTACAGGGTG
R:
CTCCGGGCACTCAGGTCTC
Band lengths:
207-474
Functional annotations
There are 1 annotated functions for this event
PMID: 11683420
LTBP-4delta8-Cys3rd (skipping of both exons) does not bind TGF-beta and it was found to be expressed in the same tissues as the full length LTBP-4
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]