DmeINT0029108 @ dm6

FBgn0040068 | Vav

The gene Vav guanine nucleotide exchange factor is referred to in FlyBase by the symbol DmelVav (CG7893, FBgn0040068). It is a protein_coding_gene from Dmel. It has 5 annotated transcripts and 5 polypeptides (3 unique). Gene sequence location is X:19261820..19273280. Its molecular function is described by: Ras guanyl-nucleotide exchange factor activity; Rac guanyl-nucleotide exchange factor activity. It is involved in the biological process described with 20 unique terms, many of which group under: embryo development ending in birth or egg hatching; regulation of adherens junction organization; epithelial cell migration; protein phosphorylation; positive regulation of catalytic activity. 17 alleles are reported. The phenotypes of these alleles manifest in: eye-antennal disc; embryonic/larval dorsal branch; midline crossing tract; longitudinal connective; dorsal closure embryo. The phenotypic classes of alleles include: increased mortality during development; some die during pupal stage; phenotype; immune response defective. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages.

• DmeEX0006974
• DmeEX0006975