FBgn0040068 @ dm6
Biotype
protein_coding
Gene Symbol
Vav
Description
The gene Vav guanine nucleotide exchange factor is referred to in FlyBase by the symbol DmelVav (CG7893, FBgn0040068). It is a protein_coding_gene from Dmel. It has 5 annotated transcripts and 5 polypeptides (3 unique). Gene sequence location is X:19261820..19273280. Its molecular function is described by: Ras guanyl-nucleotide exchange factor activity; Rac guanyl-nucleotide exchange factor activity. It is involved in the biological process described with 20 unique terms, many of which group under: embryo development ending in birth or egg hatching; regulation of adherens junction organization; epithelial cell migration; protein phosphorylation; positive regulation of catalytic activity. 17 alleles are reported. The phenotypes of these alleles manifest in: eye-antennal disc; embryonic/larval dorsal branch; midline crossing tract; longitudinal connective; dorsal closure embryo. The phenotypic classes of alleles include: increased mortality during development; some die during pupal stage; phenotype; immune response defective. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages.
Coordinates
chrX:19261820-19273280:+
Assembly
GENOMIC BROWSER[edit]
EXPRESSION VALUES[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)
EVENTS AND AS PROFILES[edit]
Associated events[edit]
Event
Type
Length
Coordinates
Strand
PSI Average
PSI Range
Annotated Functions
Orthologous genes[edit]
| Organism | Assembly | Gene ID | Gene Name | Orthology Type
|
|---|---|---|---|---|
| Human | hg38 | ENSG00000134215 | VAV3 | 1-to-3 |
| Human | hg38 | ENSG00000141968 | VAV1 | 1-to-3 |
| Human | hg38 | ENSG00000160293 | VAV2 | 1-to-3 |
| Human | hg19 | ENSG00000134215 | VAV3 | 1-to-3 |
| Human | hg19 | ENSG00000141968 | VAV1 | 1-to-3 |
| Human | hg19 | ENSG00000160293 | VAV2 | 1-to-3 |
| Mouse | mm10 | ENSMUSG00000009621 | Vav2 | 1-to-3 |
| Mouse | mm10 | ENSMUSG00000033721 | Vav3 | 1-to-3 |
| Mouse | mm10 | ENSMUSG00000034116 | Vav1 | 1-to-3 |
| Mouse | mm9 | ENSMUSG00000009621 | Vav2 | 1-to-3 |
| Mouse | mm9 | ENSMUSG00000033721 | Vav3 | 1-to-3 |
| Mouse | mm9 | ENSMUSG00000034116 | Vav1 | 1-to-3 |
| Rat | rn6 | ENSRNOG00000007422 | Vav2 | 1-to-3 |
| Rat | rn6 | ENSRNOG00000020485 | Vav3 | 1-to-3 |
| Rat | rn6 | ENSRNOG00000050430 | Vav1 | 1-to-3 |
| Cow | bosTau6 | ENSBTAG00000004511 | VAV2 | 1-to-3 |
| Cow | bosTau6 | ENSBTAG00000031575 | VAV3 | 1-to-3 |
| Cow | bosTau6 | ENSBTAG00000039160 | VAV1 | 1-to-3 |
| Chicken | galGal4 | ENSGALG00000002699 | VAV2 | 1-to-2 |
| Chicken | galGal3 | ENSGALG00000002699 | VAV2 | 1-to-2 |
| Zebrafish | danRer10 | ENSDARG00000044718 | vav2 | 1-to-4 |
| Zebrafish | danRer10 | ENSDARG00000057107 | VAV3 (1 of 3) | 1-to-4 |
| Zebrafish | danRer10 | ENSDARG00000075962 | vav3b | 1-to-4 |
| Zebrafish | danRer10 | ENSDARG00000086623 | vav3a | 1-to-4 |