DreEX6007826 @ danRer10
Exon Skipping
Gene
ENSDARG00000043313 | ank2b
Description
ankyrin 2b, neuronal [Source:ZFIN;Acc:ZDB-GENE-041010-165]
Coordinates
chr7:57657671-57659364:-
Coord C1 exon
chr7:57659266-57659364
Coord A exon
chr7:57659008-57659106
Coord C2 exon
chr7:57657671-57657769
Length
99 bp
Sequences
Splice sites
3' ss Seq
AATATTTTTGTCTTTGTCAGAAT
3' ss Score
7.29
5' ss Seq
GTGGTGAGT
5' ss Score
8.95
Exon sequences
Seq C1 exon
TTGGGATACACACCTCTTATTGTGGCCTGTCACTATGGAAATGCTAAGATGGTTAATTTTCTGTTGAAGAGTGGGGCAAGTGTCAACGATAAAACAAAG
Seq A exon
AATGGTTATACACCTTTGCACCAGGCTGCACAACAAGGCAACACACACATCATTAATGTCTTACTCCAGTATGGGGCCAAACCCAATGCCATCACTGTG
Seq C2 exon
AATGGAAACACTGCTCTTGCCATTGCACGTCGCCTTGGATACATTTCTGTGGTAGACACACTAAGAGTGGTCACAGAAGAAATTGTCACAACAACAACA
VastDB Features
Vast-tools module Information
Secondary ID
ENSDARG00000043313-'33-31,'33-30,35-31=AN
Average complexity
A_S
Mappability confidence:
100%=100=100%
Protein Impact
Alternative protein isoforms (No Ref)
No structure available
Features
Disorder rate (Iupred):
C1=0.061 A=0.248 C2=0.000
Domain overlap (PFAM):
C1:
PF127962=Ank_2=FE(35.2=100)
A:
PF127962=Ank_2=PD(31.9=87.9)
C2:
NO
Main Skipping Isoform:
NA
Other Skipping Isoforms:
NA
Associated events
Conservation
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
CACACCTCTTATTGTGGCCTGT
R:
TCTGTGACCACTCTTAGTGTGTCT
Band lengths:
168-267
Functional annotations
There are 1 annotated functions for this event
PMID: 14722080
Exon 21 (HsaEX0004130) encodes ankyrin repeat 23. InsP3R-Ankyrin-B Interaction Requires Tips of beta-Hairpin Loops of ANK Repeats 22-24, and therefore it is expected to be affected by skipping. The function of Hsa0004130 has not been examined in isolation.
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]