RnoEX6011464 @ rn6
Exon Skipping
Gene
ENSRNOG00000011076 | Ank2
Description
ankyrin 2 [Source:RGD Symbol;Acc:620156]
Coordinates
chr2:231301197-231306619:-
Coord C1 exon
chr2:231306521-231306619
Coord A exon
chr2:231302457-231302555
Coord C2 exon
chr2:231301197-231301295
Length
99 bp
Sequences
Splice sites
3' ss Seq
GCCGTCGTTGTGATCCACAGAAT
3' ss Score
8.04
5' ss Seq
GCGGTAAGG
5' ss Score
9.63
Exon sequences
Seq C1 exon
CTTGGTTACACACCTTTAATCGTTGCCTGTCACTACGGGAATGTGAAAATGGTCAACTTCCTTCTAAAACAGGGAGCAAACGTCAATGCAAAAACCAAG
Seq A exon
AATGGCTATACACCTTTGCACCAAGCTGCCCAGCAGGGACACACACACATCATTAATGTGCTGCTCCAGCATGGGGCCAAACCTAATGCTACCACTGCG
Seq C2 exon
AATGGTAACACAGCCCTGGCGATTGCTAAGCGGCTGGGCTACATCTCCGTGGTTGACACCCTGAAGGTTGTGACTGAAGAGGTCACCACCACTACCACG
VastDB Features
Vast-tools module Information
Secondary ID
ENSRNOG00000011076-'53-44,'53-43,54-44=AN
Average complexity
A_S
Mappability confidence:
100%=100=100%
Protein Impact
Alternative protein isoforms (No Ref)
No structure available
Features
Disorder rate (Iupred):
C1=0.061 A=0.359 C2=0.121
Domain overlap (PFAM):
C1:
PF127962=Ank_2=FE(34.4=100)
A:
PF127962=Ank_2=PD(33.3=93.9)
C2:
NO
Main Skipping Isoform:
NA
Other Inclusion Isoforms:
Other Skipping Isoforms:
NA
Associated events
Conservation
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
AATCGTTGCCTGTCACTACGG
R:
GTGGTAGTGGTGGTGACCTCT
Band lengths:
180-279
Functional annotations
There are 1 annotated functions for this event
PMID: 14722080
Exon 21 (HsaEX0004130) encodes ankyrin repeat 23. InsP3R-Ankyrin-B Interaction Requires Tips of beta-Hairpin Loops of ANK Repeats 22-24, and therefore it is expected to be affected by skipping. The function of Hsa0004130 has not been examined in isolation.
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]