DreEX6090152 @ danRer10
Exon Skipping
Gene
ENSDARG00000097827 | LRP1 (2 of 2)
Description
low density lipoprotein receptor-related protein 1 [Source:HGNC Symbol;Acc:HGNC:6692]
Coordinates
chr11:1858551-1866930:+
Coord C1 exon
chr11:1858551-1858644
Coord A exon
chr11:1864039-1864183
Coord C2 exon
chr11:1866445-1866930
Length
145 bp
Sequences
Splice sites
3' ss Seq
TCTGTATTGTGTGTCTGCAGAGC
3' ss Score
9.73
5' ss Seq
AAAGTAAGA
5' ss Score
6.91
Exon sequences
Seq C1 exon
GAACAGCTTCGATAGTGATTCCAGTGATTTTACTGATTCTGCTGGTGTTGTTGATTGGCGGAGCGGCGTTGTGGTACAGAAAGAGAATGAGAGG
Seq A exon
AGCCAAAGGCTTCCAGCATCAGAGGATGACCAACGGCGCCATGAATGTGGAGATCGGGAACCCGGCCTATAAAATATATGAAGGAGAGCAGGACGATGATGTTGGAGAACTGCTGGACGCAGACTTCACACTGGATCCTGACAAA
Seq C2 exon
CCGACCAACTTCACGAACCCGGTGTATGCGACACTGTACATGGGCGCTCACAACAGCCGAAACTCTCTGGCCAGCACAGACGAGAAGAAAGAGCTGCTGTCACGAGGAGATGAAGAACCGCTGGTGGACCCGCTGGCTTAAACACACACAAACACACACACACAAACATACACACACGACATACCGTTTGCCTTTTTAACGAAACGAAGAATACATGACGAAAATCAGTTAAGTGTTAACACTGTATAAAATGTACAAAAATGGACTACTTTTGTATGTGATTGCAGTATTATATTTTGTTCTTTTACAATTCCTCTGATCACAAAAAAACATCGCAAGACAACGAACGATACATTTTCTACGACAACAAAAAGAAATATGCTTCTTTTTTCCTTATTTTTTGATTATTTTGATTTTTAGGTCACCTCCCTTCTACCTTAATAGCCACTACCTCTGTGCAATATGGAGTCAAAAAACACGAAAAAA
VastDB Features
Vast-tools module Information
Secondary ID
ENSDARG00000097827-'100-109,'100-108,103-109=AN
Average complexity
A_C1
Mappability confidence:
100%=100=100%
Protein Impact
Alternative protein isoforms (No Ref, Alt. Stop)
No structure available
Features
Disorder rate (Iupred):
C1=0.000 A=0.218 C2=0.529
Domain overlap (PFAM):
C1:
PF142831=DUF4366=FE(25.2=100)
A:
PF142831=DUF4366=PD(26.0=65.3)
C2:
NO
Main Skipping Isoform:
ENSDART00000164394fB496
Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
NA
Associated events
Conservation
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
CTGCTGGTGTTGTTGATTGGC
R:
AAGGCAAACGGTATGTCGTGT
Band lengths:
250-395
Functional annotations
There are 3 annotated functions for this event
PMID: 15115822
Encodes an experimentally validated Eukaryotic Linear Motif (ELM). Method: coimmunoprecipitation, glutathione s tranferase tag, knock out, mutation analysis, pull down. ELM ID: ELMI001560; ELM sequence: EIGNPTYK; Overlap: FULL
PMID: 16382151
Encodes an experimentally validated Eukaryotic Linear Motif (ELM). Method: coimmunoprecipitation, glutathione s tranferase tag, knock out, mutation analysis, pull down. ELM ID: ELMI001560; ELM sequence: EIGNPTYK; Overlap: FULL
PMID: 18381291
Encodes an experimentally validated Eukaryotic Linear Motif (ELM). Method: mutation analysis, nuclear magnetic resonance. ELM ID: ELMI001543; ELM sequence: EIGNPTY; Overlap: FULL
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]