HsaEX0029164 @ hg38
Exon Skipping
Gene
ENSG00000100453 | GZMB
Description
granzyme B [Source:HGNC Symbol;Acc:HGNC:4709]
Coordinates
chr14:24631858-24633075:-
Coord C1 exon
chr14:24632915-24633075
Coord A exon
chr14:24632324-24632459
Coord C2 exon
chr14:24631858-24632118
Length
136 bp
Sequences
Splice sites
3' ss Seq
TCACTCTGCTCTCTGTGCAGCTC
3' ss Score
10.6
5' ss Seq
CAGGTGAGG
5' ss Score
10.07
Exon sequences
Seq C1 exon
ACTTTTCCTTCAGGGGAGATCATCGGGGGACATGAGGCCAAGCCCCACTCCCGCCCCTACATGGCTTATCTTATGATCTGGGATCAGAAGTCTCTGAAGAGGTGCGGTGGCTTCCTGATACGAGACGACTTCGTGCTGACAGCTGCTCACTGTTGGGGAAG
Seq A exon
CTCCATAAATGTCACCTTGGGGGCCCACAATATCAAAGAACAGGAGCCGACCCAGCAGTTTATCCCTGTGAAAAGACCCATCCCCCATCCAGCCTATAATCCTAAGAACTTCTCCAACGACATCATGCTACTGCAG
Seq C2 exon
CTGGAGAGAAAGGCCAAGCGGACCAGAGCTGTGCAGCCCCTCAGGCTACCTAGCAACAAGGCCCAGGTGAAGCCAGGGCAGACATGCAGTGTGGCCGGCTGGGGGCAGACGGCCCCCCTGGGAAAACACTCACACACACTACAAGAGGTGAAGATGACAGTGCAGGAAGATCGAAAGTGCGAATCTGACTTACGCCATTATTACGACAGTACCATTGAGTTGTGCGTGGGGGACCCAGAGATTAAAAAGACTTCCTTTAAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSG00000100453-'4-9,'4-6,7-9
Average complexity
S
Mappability confidence:
100%=100=100%
Protein Impact
ORF disruption upon sequence exclusion
Show PDB structure
Features
Disorder rate (Iupred):
C1=0.067 A=0.283 C2=0.239
Domain overlap (PFAM):
C1:
PF0008921=Trypsin=WD(100=96.0),PF0008921=Trypsin=PU(1.5=4.0)
A:
PF0008921=Trypsin=FE(20.5=100)
C2:
PF0008921=Trypsin=PD(0.1=0.0),PF0008921=Trypsin=FE(66.9=100)
Associated events
Other assemblies
Conservation
Chicken
(galGal3)
No conservation detected
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
AAGTCTCTGAAGAGGTGCGGT
R:
TCGCACTTTCGATCTTCCTGC
Band lengths:
256-392
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- The Cancer Genome Atlas (TCGA)
- Genotype-Tissue Expression Project (GTEx)
- Autistic and control brains
- Pre-implantation embryo development