HsaINT0048745 @ hg19
Intron Retention
Gene
ENSG00000006377 | DLX6
Description
distal-less homeobox 6 [Source:HGNC Symbol;Acc:2919]
Coordinates
chr7:96636950-96640352:+
Coord C1 exon
chr7:96636950-96637143
Coord A exon
chr7:96637144-96639107
Coord C2 exon
chr7:96639108-96640352
Length
1964 bp
Sequences
Splice sites
5' ss Seq
CAGGTAATT
5' ss Score
8.55
3' ss Seq
GATTGCTGCATTTCTTGCAGGTG
3' ss Score
9.56
Exon sequences
Seq C1 exon
ATCAACAAAAAACTACAGTGATTGAAAACGGGGAAATCAGGTTCAATGGAAAAGGGAAAAAGATTCGGAAGCCTCGGACCATTTATTCCAGCCTGCAGCTCCAGGCTTTAAACCATCGCTTTCAGCAGACACAGTATCTGGCCCTTCCAGAGAGAGCCGAACTGGCAGCTTCCTTAGGACTGACACAAACACAG
Seq A exon
GTAATTCCCGAGAAGCCCAAGTATCCCTGAAATGCTGGTACCGCTTGCAGATCGGGCAGGGAGCACATCAGGAGGAATTGTTGGCCTAGTCAACCAAGGATGGAAGGAGCTTAATGACAAATGCCTTTTGCTCCAGTTATGCACTTTCCTGGGACAACACAGTTTGGAATGAATGACCTGGTATTGAATACTGGATTGGATTTGCACATCCTCCCAACCCTCGGCGACCCCACCCCAGCCTAGAATCCTTTTGTGACCAAACTCATAATTCAATTGAGTGTTATTCCAGAGCAGAACAACATGAAAGAGAACAAACATTTAGGAGAAAAAGGTGTACAAGCCAGGAGGCAGAATAAGGTTCAACTTTTTTAAGGATCCTTTTGTAGGCCCTGGGAACTAATAAGGTTTTCAACCCATTGACACAGAAAGAAAACTTGTGAAATGAACTAAGAAAAAACAAAGTAGGCATAGGTTCCAATGAGGTTTAGTAAAGGCTCCAAAGTGCAATCTATTTATCCTAGGAGTGTCAAGGTGGGTTTTTCTGAAGATTTCCCTAAGCACGGTGGTTAAGTCATCTGGGTGACAGACTGATGTGGTCTGAGCTGCCTCCCTGGAGCACAGGACTTGGGTGCAGTGGCAGAGTTGGAGATCAAAGAGAAATGTTACCAAAATTGTAACAGGTGAAGCCACAGTTAAGTACAGTTACTGAAGTTCTCCCATCCTACTAATTTGAAAGCCATAGAAGGCATTTCAGATTTCACAAGAAGGAGCTTAGGTGAGTATATTAGGACCCTGGTCAAAAAGCCAGGCTGCAATCACCTGCAGTTTTTGTTGATTAATTTACCTACATGGAGTAAGTAGGCCTCATCTGATGTAGGTAATCTTCAGCAAGGGGACCTCAGGTTTTATGAGACTGTTGCTGCAGACTGATTGTGTGTTGACTTAAGACAGTTGTTCCTTAAGCTCTTTTTCAATTTAGCCTGTTTTCTCTTTCCATATTGCTATTCATAATATTTGGGGTTTGATATGAAGGGATTCCGGCTATTCAGTGACTTGTATGCGTCTTGAAAAAGTAGATTCTTATGGCTAGGGAATTTTAAAGGTAAAGGAAGCTGCACCATAAAATTTCCTTCTTCAAATAAAGTAGATCTGAAATGTTGGCCTAGATATGCTCCCATCCCAGATTCCCGATTCACGTTTAATTTTCAGAAGCCCTTTGACTTTTAATTACTATACTAACAATCATGTGATGATCCTTGACCACAGTTTGACTAGGCAACATACAAAATAGGGAATGAAGGAGCTGCAGTCCTTAATCCCTGCAAGGTTATGGGGATATATTTATGTCTGGAGAAAGATGCTTCATGTATAATCTATGGCATATGCAATATATGCATAGATATATTCAAGGCATTTAGTTATAAATGTACAGGCTTTAATTCCTTCAGTCATTTGCTCCTTGTACCTTTATAGAGATAACAGCTTTTGGGTATCTCTATGCATGTACACGGAGAAAATGACTGTGTAAAATAGTTATTTTACATAGACTAAATTTACATTACTAAATTTTATGTAAAATGACAAGACTTTCAGAGGAGGTGCATTCAATTGAATGGCTTTGATTTGAAAGGGCTGCTTTTAAAAATCCTTTAGGCTTTGGACCTGGTCATCTCATTCAGCTTTTTCTTATTTATACTGTTGTTTTAAACCTACGCTAGCACGCAATTCTAGAATTACAATAACTTTAGGTATCCAGGCAAGATACCTAGTATGTTGTAGGAAGTGGGACTGTAAGAGGCTAGAAAGAGGTGGAAGGAGGCGGGGACTTGGCTTGTAGGCGTTGGCGGTGGTTGTTTTTTGTTTTTTGTTTTTTTGCTTTTTTAATATTGCTTCTAAATCCCTGAGTGACGTTAGAGGCACTGGTTTGATGTTTATGGGCCTAATGATTGCTGCATTTCTTGCAG
Seq C2 exon
GTGAAGATATGGTTTCAGAACAAACGCTCTAAGTTTAAGAAACTGCTGAAGCAGGGCAGTAATCCTCATGAGAGCGACCCCCTCCAGGGCTCGGCGGCCCTGTCGCCACGCTCGCCAGCGCTGCCTCCAGTCTGGGACGTTTCTGCCTCGGCCAAGGGTGTCAGTATGCCCCCCAACAGCTACATGCCTGGCTATTCTCACTGGTACTCCTCTCCACACCAGGACACGATGCAGAGACCACAGATGATGTGAGTTGCCCAAGGGAACACCCTAGGGAAACGTCTGAACAAGGAAAAGAGGATCCGGGACCTGCTTGTATCTGCGAAAAGGAGCCAAAGGAGCAGGCTTAGGAGAGCTCATAAGTGTGGCAAGAAGCCGACTAGGCTCATTCTCTCTCCCTCTCTCTCTCTCTCCCTCTCCTTTCTTTTTACTTCTTCCTTTCCTCCATTCCTTCTTTCTTTCCTTTTCCTTTCTACCTTTCTTTTCTTTTTGCCTTTCACCTTTTTTCTCATTTACCTTCTCTCTTGAGCAACGTCAGTAATTGATCTTGCATCTCAGAGAGAGAGAAAGAGCATGTGTGAGAGAGAAACTGGTTTCTATGCCAGCACTCCTGAAACCCCTTACTGTAAGGATATTTTCTCTTACCCCTTGGGATCCAGGCTCTGAGTCTCTTCTCTTTGGGAGTATCCATCAAAATGACTTTTTTTAAAAACAGATTTTCCCCCAACCAGAAGAATCTGCACAAACTTGGCAGCGTTTTTACTTGTTTAATGAGTTTAAGACATTACATGGTGAAAGAGAAGCATTTTGGACTCCTGCATTTTTATTTACCATTCCCAGACTGACGAGAAAAAGAAAATTCCTCACATAACAGCCCTTCTCTAAAGAAAAAGGAAAAAGTGGCTGTAAGATTAGAACATTGCTACAAAGGGAATGCTGCATGTTTTATCAAAATGCAATGACCAGGAATGATGGTTGATTAAAAAAAAACAAAACAAAAACCACTCTTTCCCCACCCCACCCCCCCAAACCCTGAACTGGAATCAGGAAAGACGGAGGAAACAATCAAAATCACCATTCTATTGCTTTGACACCTTTACTAGGTGAATTGGTGGCATTCACAAAGCTAATAGGGACGTTTATATCAAGAAACATTTCTGTATATATTGTTGAATTTTAGTTGTACATATACTTTGTATGTTTTTGTCTTCTTTCATATATGGAGTAAAAGCCACAAAACGCTGA
VastDB Features
Vast-tools module Information
Secondary ID
ENSG00000006377-DLX6:NM_005222:2
Average complexity
IR-S
Mappability confidence:
NA
Protein Impact
Alternative protein isoforms
No structure available
Features
Disorder rate (Iupred):
C1=0.379 A=NA C2=0.542
Domain overlap (PFAM):
C1:
PF0004624=Homeobox=PU(73.7=64.6)
A:
NA
C2:
PF0004624=Homeobox=PD(22.8=15.5)
Main Inclusion Isoform:
NA
Other Inclusion Isoforms:
NA
Associated events
Other assemblies
Conservation
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
CGAACTGGCAGCTTCCTTAGG
R:
GGTCCCGGATCCTCTTTTCCT
Band lengths:
347-2311
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Autistic and control brains
- Pre-implantation embryo development
Other AS DBs:
FasterDB (Includes CLIP-seq data)
AS-ALPS (AS-induced ALteration of Protein Structure, links to PINs)
APPRIS (Selection of principal isoform)
DEU primates (Only for human)