HsaINT0099000 @ hg38
Intron Retention
Gene
ENSG00000108984 | MAP2K6
Description
mitogen-activated protein kinase kinase 6 [Source:HGNC Symbol;Acc:HGNC:6846]
Coordinates
chr17:69517500-69519432:+
Coord C1 exon
chr17:69517500-69517613
Coord A exon
chr17:69517614-69519312
Coord C2 exon
chr17:69519313-69519432
Length
1699 bp
Sequences
Splice sites
5' ss Seq
AAGGTAGAG
5' ss Score
6.38
3' ss Seq
TTCCATGCATTTCCATTCAGCGG
3' ss Score
6.56
Exon sequences
Seq C1 exon
AACTTTGAGGTGAAGGCAGATGACCTGGAGCCTATAATGGAACTGGGACGAGGTGCGTACGGGGTGGTGGAGAAGATGCGGCACGTGCCCAGCGGGCAGATCATGGCAGTGAAG
Seq A exon
GTAGAGTTGACATTCTCCCAAATGTTTTATATCTGCTGTGTATACATTTGTCCACCTCAATTGTCAACCAGCCCTTTTAATAGAAGCAAAACCATCTTCCGTAGGGTAAAACAGAAAAGATTATTTGCAGGGAACAGTATTTTCCTCCAAAGGTATGGAAAAGTCTTCCTTGGTGTGAGTTGTATCTACTTTTTATTTGTTTTTTTAACTCTTAACTCTCCCTCCACCCATTCTTCTACCATTTTTAATTTTTACAAAACTACCATGTCATCATCACACTTAAAAATAATTAATGGCCCAGGTGTGGTGGCTCACGCCTGTAATCCTAGCAGTTTGGGAGGCCAAGGCGGGTGGATCACGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATAGTGAAACCTCGTCTCTACTAAAAATACAAAAAATTAGCCAGGCATGGTGGCACACACCTGTAGTCGCAGCTACTTGGGAGGTTGAGGCAGGAGAATCACTTGAACCCGGGAGGTGGAGGTTGTGGTGAGCCGAGATCGTGCCACTGCACTCCGGCCTGGACAACAGAGTGAGACTCCATCTCAAATAATATTAATAATAATAATAATAATAATGATACTTCCTTCATCTAATCCGGAGTCCAAATGAAAATTTCCTTGATCATCTCAAAGTGTGTGTGTTTGTTTTGTCCTGTTGGATTTTCAAATCAGCATCCCAATGAAAGTTTACGTATTGCATTTGGCTGTTATGACTCATAGATCTCTTTTATTCTATATTTTGTTGCTTTTAAAGAATTGCCTCTGAAAATCAAGAAACCAGAATTGGGAGAGAAAATTGTCTCCATTTGTGGAAAAAGGAGGGTAAAATATATCTAGAGTAAATTTGCATAGTTTTTGAGCTATGAAAGGAAATTTAAAATCATTTCATATTATTGAGTAGGTGTTTGGAGGATCATAAAGAATTAACATCTCTAGCTGAGTTAATAGATTGGGGCTATTGTTAGGAATAATCAGGTGACTTGGATCCTTTTGCTTTTAAAGAATGGGAATACTTTTATCTTGTAGATTTTTCAGTCTGTTCTTCTGCTGACTTGCTAAGTAGGCAAAAAGTGTGAAGTCCCAGTGATATTGTATCTCTCCTATCATTTAATGACATAATCATGTTTCTGTAAGGCTACATTTCCTAGTGTGACAGATTGTTCTTCCCTCAGAAGCACTGGGATAGGAATGAACAGTTTCTCTATTTCTCTAATTGCTTCTATTTTGTATAGCTGTACCAATTCTCTTACAGTTGCTGTTCCCTCCAAATACTCTTACATGTTCCCAAAGAAGAGCTTTTGGCTTTTTATTTTCTTGGGACCCCAGATAAGCAGCAAAGTCCTTAATATTGTGCCCTCTTTGCACTGAACAGACATAATACAGTAAACCAGATTGTTTTCATACCTTGGAAATACATTCCAAAACATTTTGTCACTCTCCAAAACACACTATCAATTTGTTTCTTACCAGGACTATTCAGGAAATCAAATGAGTAACAGCCTTCCTTATTTTCATGTGTTACAAATAGCTAATCACTTTGGGTGGCTATTCACAATGTCATCGCCAGAACTTGTGTCATGAACTATTTTCACGATGGGACTCCTTCAGGTCCCTGCCTGCCTCATCCTCAGAGTAGTAACCATAAATTTTCCATGCATTTCCATTCAG
Seq C2 exon
CGGATCCGAGCCACAGTAAATAGCCAGGAACAGAAACGGCTACTGATGGATTTGGATATTTCCATGAGGACGGTGGACTGTCCATTCACTGTCACCTTTTATGGCGCACTGTTTCGGGAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSG00000108984:ENST00000590474:4
Average complexity
IR
Mappability confidence:
NA
Protein Impact
ORF disruption upon sequence inclusion
No structure available
Features
Disorder rate (Iupred):
C1=0.024 A=NA C2=0.028
Domain overlap (PFAM):
C1:
PF0006920=Pkinase=PU(39.7=76.3)
A:
NA
C2:
PF0006920=Pkinase=FE(53.4=100)
Main Inclusion Isoform:
NA
Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
Associated events
Other assemblies
Conservation
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
ACTTTGAGGTGAAGGCAGATGAC
R:
CCCGAAACAGTGCGCCATAAA
Band lengths:
231-1930
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Autistic and control brains
- Pre-implantation embryo development