HsaINT0100398 @ hg19
Intron Retention
Gene
ENSG00000204406 | MBD5
Description
methyl-CpG binding domain protein 5 [Source:HGNC Symbol;Acc:20444]
Coordinates
chr2:149215772-149220253:+
Coord C1 exon
chr2:149215772-149216440
Coord A exon
chr2:149216441-149220150
Coord C2 exon
chr2:149220151-149220253
Length
3710 bp
Sequences
Splice sites
5' ss Seq
CAGGTAAGT
5' ss Score
10.86
3' ss Seq
TTTTTAAACTATTTTTACAGTCC
3' ss Score
7.15
Exon sequences
Seq C1 exon
GCTACATTATTGGAATTTTGAAGTCATGAAAACATCAGATGAACCAACCTGCAACACCTTGGATTCAGATTGGAAGATAAAGAGAAAGTTTAAAGAATGTGGCCTATAAAGGCGGGTACCTGGAAATATTAACCGACTCACACTGTAAAAATGAGACCAGTTTCTAAACAATAGAGATTGTCTTAGTACAACATCAAGGTTCAAGACAAATGTTGAACTAAAAACTTTACACTCCCCACCCCCACTTCAGACAGGTACCAGCATTGGTGAATTATGATTTTCCTTAGTCAGAAGCACTCATTTTTACCCATGTAGACCATCCTTAGGAATTAAATATTGGTTATTTAATGTAGATTATAATGGGAAGCTGATTTTTTTCACAATGGCATATTTCAAGGACTTGGTTCCAAACTGAGCTGAAGCTTCCCAATGCGTTTTGTACAGTCTGGGAAAAACTGTGCTGCACTGGCCCACTTTTGAAGGCCATCATGCTCTGTAATATAAGGATATCATCTTATTGCTGATATCTTTGGAGAGTCCCTAGCAGACACAGAAAATGAATGGAGGCAAAGAGTGTGACGGAGGGGACAAGGAAGGAGGTCTTCCAGCTATACAAGTTCCTGTGGGTTGGCAGCGTCGTGTGGATCAAAATGGAGTGCTTTATGTCAG
Seq A exon
GTAAGTTCTTATTATTACCTGTGGTACCTGCAAAGTTGTACTCCAAAGACTAAGGAGAGAACCAAGCATGGTGACTGATGGCACCTCATATAAATGTGAAAAAGTGACCTTTGTGCTAGAAACATATGAGAATTTTTATTGCCTTAGATTTCCAGAGAGAATTTTTTGCATTACTTGTTTATATAAGGTGTCATTCTGCTTATCTCTGTAACAAGAATAAAGAAAAATAAGAAGATTTCTAAAAGAAACATGCAATCATCATTACCACATTCACAGGAGAATGTAAAATACTGGGAATATCACTTGACCTGATATCACTTGACAGAATTACTCTGTCCTTCAGAGTGTGTCAGCTGGCTTTTTTGATAAAATTGAGTTTTTATCCATAGAAAGTTTCAATTATTAGACTTCTTAATGCCTCATGTTAACTAAAAATACATTTCTTTTTTTCTGCATAGTCTTTAATCTATTTCCTTGCGTGTAATAGTAAAAGTGAAAAAGTCATGGAGAAGGCTCTGCATCTTACAAGTAAATAGTCATACAAATAAAATGCCTACTCTTTTCAATGTCAATGCTATACATCTGTTGTAGAACAAGTTGAATGGAATGACTAAACTGTTAAGAAGAAGTTTTAGTCTTACTCATTAAATAGTTGACATCTAAGTTCCCTACTTCATAGTTTTTCTGTAAGTGTCTGAAAGAAGATACCATAAATCTTTCTTGTGATGTAATGAAAAATTTTAGAAACAACTTAAAACTTTTTAAAAGGTATCACATTCCATTATTAGATTGATGCATTTACTTTCAGTGTGGCTATTTATATCCCAGCTTCAACAGAATTTGCCAGTCCAGCAAGAATGTATTCATAGAAATGAGATATTTTTGGTTATGTAAACACAGACTATTTTATGGCATAATAACTCAGAAAGTCAGTTCAGATTCTGTCCTGAGTTTGTTTGCTTGTTGTGTGTAAGGCGTTTCTGGAGGTAAATCTAATTACCAATTAAAAGCATTTTGTTGCATAAATTTTACTTCTATAATATTAAAGATGTGATCCATATTTATTGGGGTGAAGGGATAAGAAAGCAGAGAATATGAAGCTCATCCCATGGTAGATGAGATGAACAAGCACACATGAGATAACTTCTTCAGAGTTTCTATTGCCAGTGCTGTTAACAAAGTACCAGAAATACTTTGTTATAAATATAATATAGCAAGTTATCTGTGTTATATGTTTATACTTATGGTTGTTCTAGTTTATAAAGAGCAAATGTATATTCAGCATAGAACAAAAGACTCTAAAATCTGGATAATTTTTTTTTCACTTCCTTTTTGTTCCTATGAAAGATAGATGAGCTTTTTCAACTTCTGCGAGCAAAAACCAAAGTAAATCTGGGAGTCAAAAACCAAGTTAAAGTCTAAGAAACTGTCAGGTATCTTGTTCATGATTTTCTAAGTCTGACTAGACTTTATACCATCTGATATCCTTGTTAGTATGGGTTCTCCAACTTCAAATCTGTATACTGATAATTATTTTGGAAACAAGCTTTCCTAGATTAGGTAAAACACTCTCAAATTAAATTAACCAGCATAGATTTAATTTGTTTGTATATAACTAAATTACTACTTGAACATGTATAGCTCCTTCTATAGCTCCCTGCTCAATGTGCAGTTTACTCATAATTTTTAGATTGGTCTCCAGCTGCTCCTGCCTCAGGGTGGCATTGAGGCTACACATTAAATTTTCCACCTACTTCCAATCTTCTAAGCTTTATCTATGCTGTAAGTTTTTAAACTTTTTTACATTAATTATTACTCTGAGAAATTAATTAAAGAGATACAACTGAAGGAAAGAAGCCAACTGACTTTTTGAGAGGAAATGTTTTTAAAGCATCTGGAGTACTTTAATAGAATTAAGGAATTCATGTCTTCAGGTTTAATTTTACAATTAAATTCCTCTAGGATTCCGTCCATATACTTTCTTCTAAGTTAAAATGTTGGGCAGTTCCTTTTCACCAAATTCATGAATGCTTCACATGAAAAATCAACAAGACATTATACTTTTTTTCTTGTTGTTTTTGAGACAAAGTCTCACTCCGTCGCCCAGGCTGGAGTGTAGTGGCGCATCTTGGCTCACTGCAACCTCTGCCTCTTGGGTTCAAACATTTCTCATGCCTCAGCCTCCCGAGTAGCTGGAATTACAAGCACACACTACCATGCCCAGCTAATGTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTGGCCAGGCTGGTCTCAAATTCCTGACCTCAAGTGATCCGCCTGCCTCGGCCTCCCAAAGTGCTGGGTTTACAGGCGTGAGCCACTGCACTCAGCCTGACTTAGTTTATTGAAATCACCAGACCTCCAAAGACATCTTGTTGCCCTTCCCTGCAGTGGTTGAACTCGTCACTAAAATGAGAATTCTCTGCATATCACCTGAAAAAAAAATAGCCTAAGTAAATGAGTAATTTGACAAAGTTGAGGATTTTTGTTTAGATTTTCTACATGCTGAAATTACTTTCATAAGTGTCCATAAATAAAATATGAATTGCATTTTAAAGCTAGTTCACTAATAGATTTTTAAAAAATACTACTTGTGTTTTTGTAGATAGAACAATCTGTGTCCAGTATTGTAATGTTTTGTATATGAAATGGAGATTATTGTTTCTGGATGAACTTGGTCAGAGGGCTTAAGTGAAGGTTTTGGTAAATAGTCATAACTAAAAGATATTCTCAAGTGAAAAGTATATAATTTCAAAGCATAATATGTATTTAAGTTCAAACATTGACATGTTAATGTAAAGTCCTAAAATGCAGATTGTCCATCTCACATAAAATAACTCCCATTGTAAATAAAAATCAGAGACATCTCTTGTCATCTGAATTACTACTTAATCTGTATTGATGAATATTCACATATCTTACTGACTTTTGTGATCTGAAACTTCGTAACATTGAAGTACCTACACGATTATTAGCCCGAAGACCTGCGAGGCACATTTCTGCTGCCTAAAACCCTATTTCCTCATAAGTTTCCTTTCTTTTGTCAACTCTGCTTAATTCCTCTCTCTCTCTCTGTACAGTTTGACTCTTCAGTGTATCTTCGGATATAACTGATCTATTATATCTTTAAAGAAACACATGGGTAAGGGGGAGATAAAAGAAACCTGTTTTTACATAGGGACAACTTGGTTCTAGATTCCAAGATAAACAGGGACTTGCTCACTCCAACTTTTGTGGACTTGCCAACTTTCTGGTTCGAACTTCAATATGTTTCTAAATTTCTGTTTTTCCTCAAAGAGCTTTCAAAGTAGATATTCTAGTTTAAAATGAGAGTCATTGCTTTTATGTAGTTTTCTTGTTCTTTGTTCCTTTCTTGCCTGCTTCTGTCCTTTCTTAAGAATAGCATTTTTACCACCTTTAGTCTACTCTTGGTTTTCAGAATACTTTTATTTAATTTTCTATGAAGATCTGTATTTTTCTGAGAAATATTTTGGTTCAAAAGAAAACACAATATTGTTAAAGGCTATAATTTAGTAGCTAACATAATATTGACAAAGAAAATGCTTTTCCCTAGTGGGAAAATATCCCATAAAGGACAGTAAGACTATAAATTATGCCTTTTTTCATATAATATGTGTAGTCAAAATTATTTCCTGATGTTTTTTTAAACTATTTTTACAG
Seq C2 exon
TCCCAGTGGGTCTTTGTTATCTTGCTTGGAGCAGGTTAAAACATACCTGCTTACTGATGGAACATGCAAGTGTGGCTTGGAATGTCCTCTTATTCTTCCCAAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSG00000204406-MBD5:NM_018328:6
Average complexity
IR-S
Mappability confidence:
NA
Protein Impact
ORF disruption upon sequence inclusion (1st CDS intron)
No structure available
Features
Disorder rate (Iupred):
C1=0.184 A=NA C2=0.000
Domain overlap (PFAM):
C1:
PF0142914=MBD=PU(29.9=52.6)
A:
NA
C2:
PF0142914=MBD=FE(50.7=100)
Main Inclusion Isoform:
NA
Other Inclusion Isoforms:
NA
Associated events
Other assemblies
Conservation
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
No suggested primer sequences
R:
No suggested primer sequences
Band lengths:
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Autistic and control brains
- Pre-implantation embryo development
Other AS DBs:
FasterDB (Includes CLIP-seq data)
AS-ALPS (AS-induced ALteration of Protein Structure, links to PINs)
APPRIS (Selection of principal isoform)
DEU primates (Only for human)