HsaINT0107503 @ hg19
Intron Retention
Gene
ENSG00000133392 | MYH11
Description
myosin, heavy chain 11, smooth muscle [Source:HGNC Symbol;Acc:7569]
Coordinates
chr16:15850198-15851857:-
Coord C1 exon
chr16:15851684-15851857
Coord A exon
chr16:15850372-15851683
Coord C2 exon
chr16:15850198-15850371
Length
1312 bp
Sequences
Splice sites
5' ss Seq
CCGGTGAGG
5' ss Score
9.35
3' ss Seq
GCCCTACTTGTCTCCCACAGAAC
3' ss Score
10.81
Exon sequences
Seq C1 exon
GTGAACTCCTTCGAGCAGCTGTGCATCAACTACACCAACGAGAAGCTGCAGCAGCTCTTCAACCACACCATGTTCATCCTGGAGCAGGAGGAGTACCAGCGCGAGGGCATCGAGTGGAACTTCATCGACTTTGGGCTGGACCTACAGCCCTGCATCGAGCTCATCGAGCGACCG
Seq A exon
GTGAGGGGCACGTGGGCGTGCGGGGCTCCGTCACACCTTGTACACGTGTGTGGCCTCTGTGGAGCCGACGTGGACCCCACACTCTCCCCATGCACATAGCATTCCCCCACCCAATCCATCACCCAGTCCTGAAAGGCTGTAAGCTGAATCCTTGTGAACTCTTACAATTTCCATTAACCCACATTTTCATATCAAAGGTATTTTCTTTAATTTCTGCCTTCCTTCCATCCTCTTTTTTCTTCCTTTTTTTCTTCCCTACCCTCTTTCCCTTCCCTTTCCTTCTCTGCCATTGCTTTTTTTTTTTTTTTTTTTTTTTTTATGACATGGTCTGACTCTGTTGCCCAGGCTGGAGTGCAGTGGCACAATCTTGCCTCACTGCAACCTCCACCTCCCTGCCTCAAGTGATCCTCCCGCCTCAGCCTCCCAAGTGGCTGAGACTACAGGCGTGCACCACCACGCCCACCTAACTTTTGTATTTTCAGTAGAGACAGGGTTTCTACTAATTAGCCGGGCCTGGTGGTGCACGCCTGTGGTCCCAGCTATTTGGGAGGCTGAGGTGGGAGGATTGCTTGAGCCCTGGAGGCAGAGGTTGCTGTAAGCCGAGATTGCGCCACTGCATTCCAGCCTGGATAACAGAGTGAGACCCTGTCTCCAAAAAAAACTTTTCTAACAGGAACCCTAGGTGAATTCAAGTCAAGCAACAAATTCATTTGCAAGAATTATGAACTCGGCCGGGCGCGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCGGATCACGAGGTCAGGAGATGGAGACCATCCTGGCTAACACGGTGAAACCCCGCCTCTACTAAAAATAGAAAAAATCAGCCGGGCGCCGTGGCAGGCGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCAGGAAGCGGAGCTTGCAGTGAGTCGAGATCGCGCCACTGCACCGTCTGCCTGGGCGACAAGGCAAAACTCTGTCTCAAAAAAAAAAAAAAAAAAAAAAGAGTTATGAACTCTTCATGATGTTGCCTGCGTGTTGCCCACTAGGGGGCGGCAGCAAACATTATGTTCTGCCTTCCATCCCTGTTACTGGTCCATTGGGCACAGGGTAATTTGAAGGTAGATTTGGAAGCATGGGGGTCATAAACTCATCTTTATATGTGGGCAAATACAGTATCAGATCTCGGCGGATGCCCATGCGTTGTGTATAGTTGGCCAGCTCTTCATGGAATGCCTGAGGTTGGGTGTTCTCTCTGATTCAAGCCCTACTTGTCTCCCACAG
Seq C2 exon
AACAACCCTCCAGGTGTGCTGGCCCTGCTGGACGAGGAATGCTGGTTCCCCAAAGCCACGGACAAGTCTTTCGTGGAGAAGCTGTGCACGGAGCAGGGCAGCCACCCCAAGTTCCAGAAGCCCAAGCAGCTCAAGGACAAGACTGAGTTCTCCATCATCCATTATGCTGGGAAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSG00000133392-MYH11:NM_001040113:14
Average complexity
IR-S
Mappability confidence:
NA
Protein Impact
ORF disruption upon sequence inclusion
No structure available
Features
Disorder rate (Iupred):
C1=0.000 A=NA C2=0.052
Domain overlap (PFAM):
C1:
PF0006316=Myosin_head=FE(8.3=100)
A:
NA
C2:
PF0006316=Myosin_head=FE(8.3=100)
Main Inclusion Isoform:
NA
Other Inclusion Isoforms:
NA
Associated events
Other assemblies
Conservation
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
GTGAACTCCTTCGAGCAGCTG
R:
CAGCATAATGGATGATGGAGAACTCA
Band lengths:
343-1655
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Genotype-Tissue Expression Project (GTEx)
- Autistic and control brains
- Pre-implantation embryo development
Other AS DBs:
FasterDB (Includes CLIP-seq data)
AS-ALPS (AS-induced ALteration of Protein Structure, links to PINs)
APPRIS (Selection of principal isoform)
DEU primates (Only for human)