HsaINT0124918 @ hg19
Intron Retention
Gene
ENSG00000011405 | PIK3C2A
Description
phosphoinositide-3-kinase, class 2, alpha polypeptide [Source:HGNC Symbol;Acc:8971]
Coordinates
chr11:17141333-17143880:-
Coord C1 exon
chr11:17143735-17143880
Coord A exon
chr11:17141522-17143734
Coord C2 exon
chr11:17141333-17141521
Length
2213 bp
Sequences
Splice sites
5' ss Seq
TGGGTATGT
5' ss Score
7.43
3' ss Seq
TAATTCTATTATATATGCAGACT
3' ss Score
4.2
Exon sequences
Seq C1 exon
GTTGATTTTCCTTCTCCTGCATTTGATATTATTTATACAACTCCTCAAGTTGACAGAAGCATTATACAGCAACATAACTTAGAAACACTAGAGAATGATATAAAAGGGAAACTTCTTGATATTCTTCATAAAGACTCATCACTTGG
Seq A exon
GTATGTTCTGTTTATTCTGTTTTGGGCTAAGTATCTCCTGTAATGTAAAAGTCAAGTTAGGACTTACATTAAATAACCTGATTCTGTTCATGATTTATCAGCTTTCTTGGTGTGGAAAGTTTTCTATTTAACTTACTTTTTTTCCTTTTTTTTTTTTTTAATAATCTACAAAACTTTTGTCTCGAGGGCCAGCTAGTATTTAAGTTATTTTTAAAATTATATAAAAAGACTACATAACTGCATAAAATTTTAGAAATTTGTCAAGTCAAACCTTTTTACTTAAAAGGCAAACAATAGACTGGAAACTATATTTACAATACATATCAAGAGATTTTTTTAACCGTAAGGAACTTTTTCTTATTAATAAGATTAAGACCAAGAACTCAGTAGTCAAGGAGACTAAGTAGGAACAAGCAATTTTTTTAGAAAAATACAATACTTTTAAACAATCTGAAAAGATGTTCAATTTCTCAGTAATCAGGGAAATATAAATTAATTCAAGATACCATCTAACACATCAGAGTGGCAAAAATTAAAATACCTTGTGAAAAGTGTTGATAAGGATACATAAAATGGGAATTATACTATTTGCAGAAGTATAAAAAGCTATGTCTCCTTTGGAGAGCAATTTGGCAAAATCTACAAGGTTATAATGTGTATATTCTGTCCCAGCAGTGCCATTTGCAGTTATATAAAACTCTTTTATATTTGCTTATGGAGTCAAGAATATTCATTGCAGTACTTATTTGGATTATTGAAAAACTGTTCGGAGACTGGGCGTGGTGGCTCATGCCTGTACTCTTGACACTTTGGAAGGCTGAGGTGGGAGGATTGCTTGAGCCCAGGAGTTGGAGACCAACACTGACAATATAGTGAGACCCTGTCTCTACAAAAAAATTAAAAGTAGCCAGGCACAGTGTTGTGCATCTGTAGTCCTAGCGACTCAGGAGGCTGAGGTGGGAGAATTGCTTGAGCCCAGGAGGTCAAGGCTGCAGTGATCTATGATCTCATCACTGCACTGCAGCCTGGGCAACAGAGCAATACCCTGTCTCAAAAAAGAAAAGAAAAGAAAAGAAAAGAAAAATTGATTGGAAATGTCCATCAATAGGGATTAAATTAAGGTACATTTATCTGGTAGAGAACCATGTAACTATTAAAAATGAGATTGTAGGCTGAACGTGGTGGCTCACACCTGTAATCTCAGCACTTTGGGAGGCTGAGATGGTGGCACATGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCGCTTGAACCTGGGAGGCGGAGGTTGCAGTGAGCCAAGATCGTGCCACTGCATTCCAGCCTGGGTGACAGAGCGAGACTCCATCTCAAACAAAAATAAAATAAATAAAAATGAGATTATAGCTGTATGTACTAATTTTTAAAATAGGTTAGCTGAAGAAAACCAGGAGTAGAATAGTGTATATAGTGTATTACCACGAAAATAAAGGAAAAAAGAGGATCTACATATATCCGTGTGTGTGCCTCTGTATGAATAAACTCTCTAGAAGAGCATACAAGCTTAGGTGGTTGCCTCTTAGAAGGGGAATTAGAAGGAGAGAGATTTCACTGTATACCTTTTGCAGTGTTTGAATTTTTTCATTACTCCACATGAAATGAATAAATTTCAGTGCATGTATATGTATATATATATTTATATATATATGGATGGATAGTAAAATGGTGAAATATTTCATTCACGTAAACATTTGTGATTAAGCTTAAAACAATTAGGATCTTCAAAACAAGTCCTTTTCATTTGAACTGTATAAATATGTTCCAAAATTTTATAGTAGTATTTTTTTTTTCATAGCATTTGATTTTATTTGTACGAAATGGATGAAATCCTTGCTATCTCTTAGGGTGGGATCTGCTTTTTCAACTCTGATTTCTAGTGCCTGGCATCTAGTTAGAGCTCAATAAATTTTTATTATACTGAATTATCCTTCATTTTCCTAACTAAGCATCTTTTATCAAGACATAATCATTCCTTTCAGTTCCCGGATTAGCATTAATTACTGGCATTTGCCATACATTGCATTTTTCTATTCCAAATTAGTATTAATGATTTTATGAAGAAGTAGCTGTCCCAAATAAATAAATTTCTTCTTTGTATTTTTAATCATTGAGATTATATCATTATGTTATCACTGAGAAGTAATTTAATTCTATTATATATGCAG
Seq C2 exon
ACTTTCTAAAGAAGATAAAGCTTTTTTATGGGAGAAACGTTATTATTGCTTCAAACACCCAAATTGTCTTCCTAAAATATTAGCAAGCGCCCCAAACTGGAAATGGGTTAATCTTGCCAAAACTTACTCATTGCTTCACCAGTGGCCTGCATTGTACCCACTAATTGCATTGGAACTTCTTGATTCAAA
VastDB Features
Vast-tools module Information
Secondary ID
ENSG00000011405-PIK3C2A:NM_002645:14
Average complexity
IR-S
Mappability confidence:
NA
Protein Impact
ORF disruption upon sequence inclusion
No structure available
Features
Disorder rate (Iupred):
C1=0.000 A=NA C2=0.000
Domain overlap (PFAM):
C1:
PF0079219=PI3K_C2=PD(3.5=10.2),PF0061315=PI3Ka=PU(12.5=46.9)
A:
NA
C2:
PF0061315=PI3Ka=FE(34.2=100)
Main Inclusion Isoform:
NA
Other Inclusion Isoforms:
NA
Associated events
Other assemblies
Conservation
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
No suggested primer sequences
R:
No suggested primer sequences
Band lengths:
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Autistic and control brains
- Pre-implantation embryo development
Other AS DBs:
FasterDB (Includes CLIP-seq data)
AS-ALPS (AS-induced ALteration of Protein Structure, links to PINs)
APPRIS (Selection of principal isoform)
DEU primates (Only for human)