HsaINT0124922 @ hg19
Intron Retention
Gene
ENSG00000011405 | PIK3C2A
Description
phosphoinositide-3-kinase, class 2, alpha polypeptide [Source:HGNC Symbol;Acc:8971]
Coordinates
chr11:17135908-17139218:-
Coord C1 exon
chr11:17139038-17139218
Coord A exon
chr11:17136013-17139037
Coord C2 exon
chr11:17135908-17136012
Length
3025 bp
Sequences
Splice sites
5' ss Seq
CAGGTATGT
5' ss Score
9.8
3' ss Seq
TATCACATCTCTTTCTATAGGTT
3' ss Score
10.37
Exon sequences
Seq C1 exon
GCTTCTCAAAGATGCCCTGCATGATGTACAGTTTAGTACCCGATACGAACATGTTTTGGGTGCTCTCCTGTCAGTAGGAGGAAAACGACTTAGAGAAGAACTTCTAAAACAGACGAAACTTGTACAGCTTTTAGGAGGAGTAGCAGAAAAAGTAAGGCAGGCTAGTGGATCAGCCAGACAG
Seq A exon
GTATGTACCCATAAAAGGTAATATAAATGTGTTAATGTTAAAGGAAGGATCTTTATGGTGCTGACTAATTAAGTTGCTATTCTTTATTGGTAGACTCCCAGTAGAACTCTAACTATACCCATGCTATTTGGGGCAGATAAATTCAAAGATTGTTTAAAATATATAGGAACATATTTCACAACCTATTAAAATCAGTGATTTTCCCATGCTTATTTATTTCCATGCTTATTTATTCCTTTCTGATGAAAATTGTTTTCTTGAATTCCTTTACCTCCACTATCAAAGTCCACAGTATTTTCATCACACCAAAAAGAAAGCATGTCCCCATTTTCCCCTCCCAGCCACTAAACTGTTTTCTGTCAATATGGATACGTCTATACTTCTATATGGATATTCTGGACACTTCATGGACTTTTCTGTCTAGTTTCTTTCACTTAGCATAAAGTTTTCAGAGTTCATCTGTGTTCTAGCATGTGTACTACATGCCATTTTTGGTTGAATAATATTCCATTGTGTGGATATACCACATTTGGTTTAAACATTCATCAGTTGGTGGACATTTGGGTTGTTTCCACTTTTTGACTATTAATAATAATACTGCTGGCCAGGCGTGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCCAGGCGGGCAGATCACGAGGTCAGGAGATCGAGACCATCCTGGTTAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAAATTAGCCAGGCATGGTGGCGGGCGCCTGCAGTCCCAGCTGCTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGGCGGAGCTTGCAGTGAACCGAGATCGAGCCACTATACTCCAGCCTGGGCGACAGAGCAAGACTCTGTCTCAAAAAAAAAAAAAGAATACTGCTATGAATATTCATGTATAAATTTGTGTTTAAACAACTGTTTCCACTTAGGAATGGCAGAGCTAGGTCATATGGTAGTTCTGTGCTTAACTTTTTGGGGAATCATAGAATTATTGTCTGTAGCAGCTATATCACTTTACATTCCCACCAGCAATATAGAAGGGTTCCAGTTTCACCACATCCTCACCAACATTGTTTTTTTTCCTGTTTTTTGATTATGGCCATTCTAGTGGGTGTGAAGCAGTATCTCGTTGTGGTTTTGAGTTGAATTTCCCTAGTGACTAATGATATTGAGCACATTCTCATATGTTTATTGGCCATTTGTATTCTTTGGAGAAATATCTATTCAAAGTCCTTTGTCCATTTTAAATTGGAATGTCTTTTTTGTTGTTGAGTTGTAAGAGTTATTTATATATTTTGGATACTAGACCTTTATCACATACACTATTTGCAAATATTTTTTTCATTCTGCAGTTGTCTTTTTAATTCCTTAATAGTGTCCTTTAATATATTAATACAAAAATGTTTAAGTTTGATGAAGTCCAGTTTATCTATTTTTTTCTTTTGTGGCTCATGCTTTTAGTGTCATATCTAAGAATCCATCATTAAATCTAATGCCATAAAGATGTACACCTGTGTTTTCTTCTAAGCTTTTCTAGTTTTAGCTCTTATGTTTAGGTCTTTGATCCGTTGTGGTATGAAGTAGAGGCCCAACTTTATTCTTTTGAATGAGGTTATCCAGTTGTCTTAGCACCATTTGTTAAAGAGACCCCCTCCTTCCTCTTGAATGGTTTTGGCGTACTTGTCAAAAATCAGTTGACCCTGTGCTTGCTTCGGTAACACATATACTAAAATTGGAATGATACAGAGAAGATTAGCATGCCCCCTACACTACGATGACATGCAAATTCGTGAAGTGTTCTGTTAAAAATTTTTAAATAAAAAAGTTGACCACATATATGGGTTTTTTTCTAGACTCTCAATTCTATATCATATATGTCTATCCATATGCTATATTTGTTTTTTTTTTTTTTTTCCTTTTTTTCCTTGAGATGAGGTCTCTCTGTTGCCCAGGCTGGAGTGCAGTGGTGTGATCACAATTCACCACAGCCTCAGCCTCCTGGGCTCAAGTGATCTTCTCGCTTCAGCCTCCCAAGTAGCTGGGACCACAGGTGTTTGCCACCATGCCTGTCTTTTTTTTTTTTTTTTTTTTTTCTTGTAGGGACAGGGTTTTGCCATGTTTCCCAGGCTGGTCTTGAACTCCTGGGCTCAAGCAGTCCTCCCATTTTGGCCTCCCAAAGTCCTAGGATTATAGATATGAGCCATCCACCCAGCCTATACTTTTTTTAATTACCATAGTTTTATAGTAAGTTTTGAAATTGGACAATGTAAGTCCTCCTACTTTGTTCTTTTTCATTATTATTTTTGGCTATTCAGGGGACACTTGCAATTTCATATGAATTTTAGGAACCGTGTATCCATTGCTGCAAAAAGGCAGTTGGAATTTTGATAAGAATTATAGATTAATTTGGGGAAATATTACATACAATCTTAATTATAAACTATTACCTCTATATACATTGTTTACCTGTTTTCTCTTTACTAAACAATACTGCAATGAACTTTGGTTGGTGTGTACATTTTTATTTCTTTGCTAGTATTTCTTTCAGAAAATTCCTACAGGTGAAATAGCTGAGTCAAGAGCGACATGTATTTTTAGTTATAATAGTTGTTACATTGCTCTACAAAAGAAGCTACACCTGTGTACACCTCTCTCCCTACCAATAAGTTATGAAATCGTTTCCTAACACAGGATGTTGTTTTAAATTTTCATCTGATAGGTGAAAAACTGCATTCATTTTTGTTTGGCTTCTATTTCTTTGACTATTAGTGAGCTTTAACATTTTCGTATACATTGGTTGGCCAAATGTACCTTTGCCCACTATATTTATAGCCTTTGGCCATTCTAGTTTTATAGTAAAAATTAACTCTCTTTAGTAACAACCTTTTTTTCACCGTTTGACAACTGGGCATTTTATAAATTGTATCCACAGCATAACTTGTCTGAAAAATAGATCTTCATTTTCATTATGTACTTACAGTATCACATCTCTTTCTATAG
Seq C2 exon
GTTGTTCTCCAAAGAAGTATGGAACGAGTACAGTCCTTTTTTCAGAAAAATAAATGCCGTCTCCCTCTCAAGCCAAGTCTAGTGGCAAAAGAATTAAATATTAAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSG00000011405-PIK3C2A:NM_002645:18
Average complexity
IR-S
Mappability confidence:
NA
Protein Impact
ORF disruption upon sequence inclusion
No structure available
Features
Disorder rate (Iupred):
C1=0.000 A=NA C2=0.000
Domain overlap (PFAM):
C1:
PF0061315=PI3Ka=PD(18.5=55.7)
A:
NA
C2:
NO
Main Inclusion Isoform:
NA
Other Inclusion Isoforms:
NA
Associated events
Other assemblies
Conservation
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
No suggested primer sequences
R:
No suggested primer sequences
Band lengths:
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Autistic and control brains
- Pre-implantation embryo development
Other AS DBs:
FasterDB (Includes CLIP-seq data)
AS-ALPS (AS-induced ALteration of Protein Structure, links to PINs)
APPRIS (Selection of principal isoform)
DEU primates (Only for human)