HsaINT0133048 @ hg19
Intron Retention
Gene
ENSG00000185198 | PRSSL1
Description
protease, serine, 57 [Source:HGNC Symbol;Acc:31397]
Coordinates
chr19:691858-694970:-
Coord C1 exon
chr19:694814-694970
Coord A exon
chr19:692003-694813
Coord C2 exon
chr19:691858-692002
Length
2811 bp
Sequences
Splice sites
5' ss Seq
CAGGTGAGC
5' ss Score
9.6
3' ss Seq
CCACCACCTCCTCCCTGCAGAGA
3' ss Score
10.52
Exon sequences
Seq C1 exon
CAGGCTCCTGGGGGGCCCAGATCATCGGGGGCCACGAGGTGACCCCCCACTCCAGGCCCTACATGGCATCCGTGCGCTTCGGGGGCCAACATCACTGCGGAGGCTTCCTGCTGCGAGCCCGCTGGGTGGTCTCGGCCGCCCACTGCTTCAGCCACAG
Seq A exon
GTGAGCTCACCTGTCGGGCCCCTTCTTTCTGGACACCGTATCCCGACATGAGGGGGACTCCAGGCTGGTGGGGGAGCTGGGGGCGCCGTGGCTCCTGCAGGAGGGGGAGTCTCAGCAGGGGCTGGATTTAAAGGGCAACAAAGGGAAAACAGGAGGATAAGGCAGGGAGGCAAAAGAAGCACAGAAGAAGCAACAGGCGCAACAAGTACATATTCTGTTACTGTAACTGTCACTATGTTCTTTTTTTTTTTTGAGGCAGTCTCGGTTCCCCAGGCTGGAGTGCAACGGTGCAATCTCGGCTCACTGCAACCTCCACCTCCCGGGCTCAAGCGATTCTCCTGCCTCAGCTTCCCGAGTAGCTGGGATCACAGGCGCCCACCACCACACCTGGCTAATTTTTGCATTTTTAGTAGAGACTGGATTTCACCATGTTGGCCAGGCTGGTCTCGAACTCCTGACTTCAAATGATCCACCCGCCTCTGCCTCCCAAAGTGCTGGGATTGCAGGTGTGAGCCGCCATGCCCTGCCTCGTTTTAAACATATTGTTATAATAACTATTAAAATGTATATTGGGGCCAGGGTGGGTGGGTCCCCTCCTGCAGGAGCCCCCACCAGGCACGGGATAGGTTGGTCCTGGGCTGCAGTGTCCCCAGCTCCCCCGCCAGCCTGCAGTCCCCCTCACGTTGGGACACGGTGGATTGTTTGAGGTCAGGAGTATGAGACCAGCCTGGCCAACATGGTGAAACTCTGTCTCTACTAAAAATACGAAAATTAGGCTGGGTGCGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGAGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAATACAGTGAAACCCCATCTCTACTAAAAATACAAAAAAATTAGCCGGATGTGGTGGCAGGCGCCTGTAGTCCCAGCTACCCAGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGGCGGCGCTTTCAGTGAGCCGAGATCGCGCCACTGCACTCCAGCCTGGGGGACAGAGCGAGACTCTGTCTCAAAAAAAAAATACGAAAATTAGTTGGGCATGGTAGCAAGTGGCTGTACGTATCCCCAGCTACTCGGGAGGCTGAGGTAGGAGAATCACTTGAACCCAGGAGGTGGAGGTGGCAGTGAGCCGAGATGGCACCACTGCACTCCAGCCTAGGGGAAAGAGTGAGATTCTGTCGGAAAAAAAAAAGTTAATTGTGGTTTTTGCCATTTAATTTTTTTCGTGCAATTACTTTTGCACCAACCTAATATTATCACGGGGCCGGCGTGAGCATTAAATGGATTACTGGGCCTCCATTTCATAGATGAGTGGACTGAGGCCCAGACGGGCAGCCGTCACCCCCATCTCACCCACCCCCTCCTCCCCGCAGAGTCCTCCGCACCGGAGCTGTGCTTCTGTGGTCCCAGCTACTTGAAAGGCTGCTGTGGGAGGATCGCTTGAGCCTGGGAGGTCGAGGCTGCAGTGAGCTGTGATCACACCACTGCGGCCTGGGTGACAGAGTGAGACCTTGTCTCAAAAAAAAAAAAAAAAAAAAGGCCGGGTGCGGTGGCTCACGCCTGTAATCCCGGCACTTTGGGAGGCCGAGGCAGGCGGATCACGAGGTCAGGAGATCGAGACTGTCCTGGCTAACACGGTGAAACCCTGTCTCTACTAAAAAAAAATACAAAAAATTAGCCGGATATGGTGGCGGGCGCCTGTAGTCCCAGCTATTCAGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGGTGGAGCTTGCAGAGAGCCAAGATTGCACCACTGCAATCTTGCCTGGGTGACAGAGCGAGACTCCGTCTCAAAAAAAAAAATTAAAGAAATAAAAAAAGGAGAATATTGAAATTACTGTAGTTAATATTATAATTGAAATAGAACTTATAATAAATATAATAAGTATTATCTTCATTCTAAATATGTTTTTATAATAATGATTCAAATTAATACCACAACTATTGCAGTTAATTCTATATTGGAGGTAGGAAAAATAATAAACATAATTATTAATTTATTATCATAATATTAAGTTGGGGGCTGGGCACCGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGTGGATCACTTCAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCTGTCTCTACTGAAAATACAAAAATTAGCTGGGAGTGGTGGCGCACGCCTGTAGTCTTAGCTGCTTGGAGGGCTGAGGCAGGAGAATCACTGGAACCCAGGAGGCAGAGGTTGCAGTAAGCCTCGATTGCACTCTAGCCTAGGGGACAGAGTGAGACTCTGTCTCAAAAAAAAAAAAAAAGAAAAAAGGAAAAGAATATTAAGTTGATGCAAAAGTAATTGTTTTTTTTTTGTTTTTTTGAGACGGAGTCTTGTTCTGTCGCTCAGGCTGGAGTGCAATGGTGCAATCTCAGCTCACTGCAACCTCCGCCTCCCAGGCTCAAGCAATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATGACAGGCATGTGCCACCACACCTGGCTAATTTTGTATTTTTAGTAGAGACGGGGTTTCTCCATGTTGATCAGGCTGGTCTTGAACTCCCGACCTCAGGTGATCCACCCTCCTCACCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGTGCCCGGCCTGGGCCTCCGTTTCATAGATGAGTGGACCGAGGCCCAGGACGGGCAGCCCTCACCCCCGTCTCACCCACCACCTCCTCCCTGCAG
Seq C2 exon
AGACCTCCGCACTGGCCTGGTGGTGCTGGGCGCCCACGTCCTGAGTACTGCGGAGCCCACCCAGCAGGTGTTTGGCATCGATGCTCTCACCACACACCCCGACTACCACCCCATGACCCACGCCAACGACATCTGCCTGCTGCGG
VastDB Features
Vast-tools module Information
Secondary ID
ENSG00000185198-PRSSL1:NM_214710:2
Average complexity
IR-S
Mappability confidence:
NA
Protein Impact
ORF disruption upon sequence inclusion
No structure available
Features
Disorder rate (Iupred):
C1=0.000 A=NA C2=0.000
Domain overlap (PFAM):
C1:
PF0008921=Trypsin=PU(20.0=84.9)
A:
NA
C2:
PF0008921=Trypsin=FE(21.3=100)
Main Inclusion Isoform:
NA
Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
NA
Associated events
Other assemblies
Conservation
Chicken
(galGal4)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
No suggested primer sequences
R:
No suggested primer sequences
Band lengths:
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Autistic and control brains
- Pre-implantation embryo development
Other AS DBs:
FasterDB (Includes CLIP-seq data)
AS-ALPS (AS-induced ALteration of Protein Structure, links to PINs)
APPRIS (Selection of principal isoform)
DEU primates (Only for human)