HsaINT0145207 @ hg19
Intron Retention
Gene
ENSG00000188322 | SBK1
Description
SH3-binding domain kinase 1 [Source:HGNC Symbol;Acc:17699]
Coordinates
chr16:28328706-28330518:+
Coord C1 exon
chr16:28328706-28328938
Coord A exon
chr16:28328939-28330315
Coord C2 exon
chr16:28330316-28330518
Length
1377 bp
Sequences
Splice sites
5' ss Seq
CAGGTGAAC
5' ss Score
5.56
3' ss Seq
GTTGCTGTTGCTCCCATCAGGCA
3' ss Score
6.32
Exon sequences
Seq C1 exon
GGAGAAGATGAGCGTGGGCTGCCCAGAGCCTGAGCCGCCCCGCTCCCTGACCTGCTGTGGGCCGGGGACTGCCCCTGGGCCTGGTGCCGGTGTGCCCCTTCTCACTGAAGACATGCAGGCCCTGACTCTCCGCACACTGGCCGCCAGCGACGTCACCAAGCACTACGAACTAGTCCGGGAGCTGGGCAAAGGCACCTATGGGAAGGTTGACCTGGTGGTCTACAAGGGCACAG
Seq A exon
GTGAACAAGTGCAGGGTGGCAGGGCTGAGAGGTTGGGGTGGGGCAGGGCTGGGAGGTCAGGGTTGGGGGACATGACCTTGCAGCTGGGCCGGGGCTCTCTGGTGCTCTGTGGAAGCCAGGAGGCAGGGTCAGGGGCCAGATGTAGAGGATGAGGCCTGAGGCAGCCCAGGGGGAAAGAGACTGGGCAGATGGGGCAAGGGAGGAATCCGGGGCAGAGTGGCCAGGGTACAGGATGGGCTGCTGTGGGGCCATCTGGGGTGACTTTGAGACAGCCAAGGGGCTGTGCCAGGAGTGTCTGGGGAGGGCAGGGCTGCCGGCTGTGTCTGAGTATCACCAGCGTCTCAGGGATGTCTGGCCCCAGGAAGGTGGATGGAGAGTGAGGGTGGTTCCTCAGGAACAGGGTGCCACACTTAATGGGTGGTGGAAGGACCTGTGAGGTCAATATTGCAATCACCATCTCTCAGGTGAGGACAGGGAGACCTAGGCCAATTCAGCCACATAGCCAATGCCCTGCAGCTACAGAGGCTGTGAACCAAAACGAGACCCCAGGAGTCATCTCCAGAGCCTTGTCGCTTAGTCACTGAGCTTGATACCTCCCCCACACTGTAGGTCACAGCCGTGCCACCCAGCCAGCCAGGGGCTGGGGCTGTGTGAGCTCCCACAGCTGCACGCGCTTGGGTCCAGGGGCTTTGTGCTAACTGAGGGCAGCAGGAGGAGCACCTAACATGGGGTCACCTGAGCTTTGTTACTTGCTTGCTGTGTGACCTTGAGCAAGTGACTTCACCTCTCTGTGCTTCAGAGTCCTTCTCTGTAAAATAGGGTAACATTAGTGCACAACCCATACAATCATAATGAAGTGTGAGTTGTGAATGTGCAGTGCTGAAGGCAGGGCCTGCGATGTGTAAATGCTCCGTGGACACACATGTGTGCTCCACCCAGCTATGTACCAGATGGGCACAGATGCTTGCCCAGGCACAGAGTTGTGGACACATGCCTTGCAGTGTCTCATTTCTTATTCATTCATCCATTTAGCAAGACAGGAAGCTTAGGGAGACCCGTTCTAGATGGGGTAGGCTGACAAGATAAATAAGCATATGGCGGGCAGGACAAAATGAGAGAGGTGGAGGGCATCACAGGCCCCCTCGCCCCCTCCTCTTGGAGAGCTGCAGAGTGGGTGTAGAAGGCTCAGGTTGACCCTGCCTGCATGGCCTTGGGCAAGTCCTTTCCTCTCTCTGGGTCTGTTCCCATCCGTGAGATGAGGACAGTCATGCCTGCTGGGGACCCTGTTGCACCAGGGTCCAGAGACAGGCATGGGTGCATCCAGTGCGGAGGCACTGGGAGAGGGGGCTTCAACCCTGTTGCTGTTGCTCCCATCAG
Seq C2 exon
GCACAAAAATGGCACTGAAGTTTGTGAACAAGAGCAAAACCAAGCTGAAGAACTTCCTACGGGAGGTGAGCATCACCAACAGCCTCTCCTCCAGCCCCTTCATCATCAAGGTCTTTGACGTGGTCTTTGAGACAGAGGACTGCTACGTCTTTGCCCAGGAGTACGCACCTGCTGGGGACCTGTTTGACATCATCCCTCCCCAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSG00000188322-SBK1:NM_001024401:2
Average complexity
IR-S
Mappability confidence:
NA
Protein Impact
ORF disruption upon sequence inclusion (1st CDS intron)
No structure available
Features
Disorder rate (Iupred):
C1=0.263 A=NA C2=0.000
Domain overlap (PFAM):
C1:
PF0006920=Pkinase=PU(8.7=30.3)
A:
NA
C2:
PF0006920=Pkinase=FE(25.5=100)
Main Inclusion Isoform:
NA
Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
NA
Associated events
Other assemblies
Conservation
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
GGTGTGCCCCTTCTCACTGAA
R:
GGGGAGGGATGATGTCAAACA
Band lengths:
346-1723
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Autistic and control brains
- Pre-implantation embryo development
Other AS DBs:
FasterDB (Includes CLIP-seq data)
AS-ALPS (AS-induced ALteration of Protein Structure, links to PINs)
APPRIS (Selection of principal isoform)
DEU primates (Only for human)