HsaINT1044310 @ hg38
Intron Retention
Gene
ENSG00000146872 | TLK2
Description
tousled like kinase 2 [Source:HGNC Symbol;Acc:HGNC:11842]
Coordinates
chr17:62606130-62608148:+
Coord C1 exon
chr17:62606130-62606241
Coord A exon
chr17:62606242-62608040
Coord C2 exon
chr17:62608041-62608148
Length
1799 bp
Sequences
Splice sites
5' ss Seq
AAGGTAAGT
5' ss Score
11
3' ss Seq
TGTTTGTTTTTATGTGACAGCCT
3' ss Score
6.41
Exon sequences
Seq C1 exon
GTATTTACCACCAGAGTGTTTTGTGGTTGGGAAAGAACCACCAAAGATCTCAAATAAAGTTGATGTGTGGTCGGTGGGTGTGATCTTCTATCAGTGTCTTTATGGAAGGAAG
Seq A exon
GTAAGTTAGAAGGTTGATGGAGAAGCTTGATCTCTTTCTTGGGTGGCACACACACACACAGTGCCTTGGTATGGATTAGTCTATTGGAGTTAATTATTGGGTTATACAAAATAGAATCCTGAAAGGAGTGGTTTAAAGAAAATACAGACTTAATAATACAAGCCTTATTCGTAAGCAGAAATCCTCAACCCTAGGGCACCTAATGAGTTCTGCGGGGCTGTTAAAAACATGCACTTTTGCTGTTCTCAATTAGATCTGGAACATGTATTTATTCTGATAGTGTGTATAGGGATTTACAAAAATCGTTTATTTATTAAAGTATACAATCTTCCCAAGAACCTGGGGGCCCCAAGAACCAAAACTCAAAATATCCCCAGAATCTTTATCGCCAGCCATCCCATTAGTTGAACCTATTATTAATGAAAGCGTGCTTTATATTTCTATACTGGGGAGATGGTGTCAGGATGTATTCATTGTTACCTCTGATCAAGGTGACATATTTCAACAAGTGGTAAACTACACCTAATGAATTGTCACATTTGTTTTTCCTTGTGAACATGCCTTATAAATGTATATATTAGGATCCATTTGTGTATTTATGTTCCTATTGCTGTTTTTGTGTGTTTGTTTGTTTCAGTGTTTCCCAGTAGGCTGTGGGTATAAGCCAGATGGGAGTTCTGTGTGTCCTTTGAATTCTTAATATTTTGATTACATTCCCCAGACCAGGCTCTTAATTCAGATTATACCTTCCTCTTTAGCTTCTCCTTGGTCTTTTTTTTTTTTTTTTTTCTATCTCACCTCTCTAAAACAGGGAAACTATTCAGAGGTAGTAGGCTTAATTATTATTTACATTCCCTGACAATGTTGAATTGCTGCCGATAACAGCAGTAGAAATTATCTAGAAATAACTGTTTGAGAGAGATCTCAGTAGAACCAGTATAGAGAGACTTGAGTTGAACTTGTTTTTAAGAGTTTATTAGAAAATGGCAGCTCGGTGACCAGGCGTGGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGTGGATCACAAGATCAGGAGATCGAGACCATCCTGACTAACATGGTGAAACCCCGTCTGTACTAAAATTACCAAAAAAAAAAAAAAATTAGCCGGGCGTGGTGGCGGGTGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCATGAACCCGGGAGGCAGAGCTTTCACTGAGCTGAGATCATGCCACTGTACTCCAGTCTGGGCGACAGAGCGAGACTCCATCTCAAAAAAAAAGACAAAGGAAATGGCAGCTCGGCATAGTTGAAGCCATTAAGTAACCCCAACTCTTTCTTTTTCCCACTCTGTCCTTACCCCTCTTGGTTTTGACTTCCTTTCCTTCTCTTTTTCTGTTTTTTGAGTTGGCCTGAGGCACAGGTGTGTATTTCTTAGGGCCGCATGTATCCCTCAGAGCAGGTGAGGTTGCTGGGTCCTGCTCTAGATCTCCCTTTTCTCTGGTGTGAGCAAAGCTTAGCAGAGCATTAGGATATAGGAGATGCTGCTTCTGGTCCCCACTCTGCTTTGACCTGGTAGTTGAACTGTGAGCAAGTTACATATGCTCTGAGCTCTCAACCCCTTTTATCTATAAAGTGAGAGAACTAGAGGGGATTGTCTCCAGAGTTCCTTGCAGCAATTCAAATTAGAAGATGTCTTATCCTTTTCCTTCCCTGGGGTATTGAATTGTTTTCTCTATAATTTTCATCAGAGGCCTACATTATTTGTTTGTTTTTATGTGACAG
Seq C2 exon
CCTTTTGGCCATAACCAGTCTCAGCAAGACATCCTACAAGAGAATACGATTCTTAAAGCTACTGAAGTGCAGTTCCCGCCAAAGCCAGTAGTAACACCTGAAGCAAAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSG00000146872:ENST00000346027:20
Average complexity
IR
Mappability confidence:
NA
Protein Impact
ORF disruption upon sequence inclusion
No structure available
Features
Disorder rate (Iupred):
C1=0.000 A=NA C2=0.000
Domain overlap (PFAM):
C1:
PF0006920=Pkinase=FE(13.2=100)
A:
NA
C2:
PF0006920=Pkinase=FE(12.5=100)
Main Inclusion Isoform:
NA
Other Inclusion Isoforms:
NA
Associated events
Conservation
Zebrafish
(danRer10)
No conservation detected
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
TTACCACCAGAGTGTTTTGTGGT
R:
TTGCTTCAGGTGTTACTACTGGC
Band lengths:
214-2013
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Autistic and control brains