MmuEX0004887 @ mm10
Exon Skipping
Gene
ENSMUSG00000031543 | Ank1
Description
ankyrin 1, erythroid [Source:MGI Symbol;Acc:MGI:88024]
Coordinates
chr8:23123832-23135834:+
Coord C1 exon
chr8:23123832-23123978
Coord A exon
chr8:23132097-23132634
Coord C2 exon
chr8:23135558-23135834
Length
538 bp
Sequences
Splice sites
3' ss Seq
CCCTCTGTCTGCCCTTCCAGGTT
3' ss Score
12.85
5' ss Seq
CAGGTAAGG
5' ss Score
11.08
Exon sequences
Seq C1 exon
TGGAGAATTTGTACACAGCCCTGCGGAACATCGACAGGAGTGAGATTGTTAACATGTTGGAGGGCTCCGGCAGGCAGAGCAGAAACCTCAAACCAGAGCGGAGACATGGGGACCGGGAGTACTCATTGTCACCCTCCCAGGTGAATG
Seq A exon
GTTACTCCTCGCTGCAGGACGAGCTGCTGTCCCCCGCCTCCCTGCAGTACGCTCTCCCCTCTCCACTGTGTGCAGACCAGTACTGGAACGAAGTGGCCGTCATAGACGCCATCCCCCTGGCGGCTACAGAGCATGACACCATGCTGGAGATGTCTGACATGCAGGTGTGGTCTGCGGGCCTCACACCCTCCCTGGTCACTGCTGAGGACTCCTCTCTGGAGTGCAGCAAGGCTGAGGACTCTGACGCCATACCAGAGTGGAAGTTGGAAGGGGCACACTCAGAGGACACGCAGGGCCCGGAGCTGGGCTCTCAGGACCTGGTGGAGGACGACACAGTGGATTCAGATGCCACAAATGGCCTGGCAGATTTGCTAGGTCAGGAGGAAGGTCAGAGGTCAGAAAAGAAGAGGCAGGAAGTCTCAGGCACAGAGCAGGACACGGAGACTGAAGTGTCTCTTGTTTCAGGCCAGCAGCGAGTTCACGCCCGAATCACAGACTCACCCTCAGTGAGGCAGGTGCTGGACAGAAGCCAGGCCAG
Seq C2 exon
AACACTGGACTGGGATAAACAGGGTTCCACAGCGGTACACCCGCAAGAAGCCACACAGAGCTCCTGGCAAGAGGAGGTCACGCAGGGCCCACACTCATTCCAGAGAAGGATCACCACCATCCAAGGGCCGGAGCCTGGTGCGCTTCAGGAATACGAGCAGGTGCTGGTGTCTACCAGGGAGCATGTGCAGAGGGGGCCACCTGAGACCGGCAGCCCCAAAGCTGGCAAGGAACCTAGCCTGTGGGCACCTGAGAGCGCCTTCTCTCAAGAGGTGCAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSMUSG00000031543-'50-69,'50-66,57-69
Average complexity
C1
Mappability confidence:
100%=100=100%
Protein Impact
ORF disruption upon sequence exclusion
No structure available
Features
Disorder rate (Iupred):
C1=0.510 A=0.702 C2=1.000
Domain overlap (PFAM):
C1:
PF0053117=Death=PD(27.4=46.0)
A:
NO
C2:
NO
Main Skipping Isoform:
NA
Other Inclusion Isoforms:
Other Skipping Isoforms:
NA
Associated events
Other assemblies
Conservation
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
CAGGCAGAGCAGAAACCTCAA
R:
CTGCACCTCTTGAGAGAAGGC
Band lengths:
354-892
Functional annotations
There are 1 annotated functions for this event
PMID: 1388161
Skipping (probably more as an ALTA) exhibits increased affinity for the cytoplasmic domain of the anion exchanger, spectrin, and tubulin.
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Pre-implantation embryo development
- Ribosome-engaged transcriptomes of neuronal types
- Neural differentiation time course
- Muscular differentiation time course
- Spermatogenesis cell types
- Reprogramming of fibroblasts to iPSCs
- Hematopoietic precursors and cell types