Special

MmuEX0004887 @ mm9

Exon Skipping

Gene
ENSMUSG00000031543 | Ank1
Description
ankyrin 1, erythroid [Source:MGI Symbol;Acc:MGI:88024]
Coordinates
chr8:24234304-24243106:+
Coord C1 exon
chr8:24234304-24234450
Coord A exon
chr8:24242569-24242955
Coord C2 exon
chr8:24243034-24243106
Length
387 bp
Sequences
Splice sites
3' ss Seq
CCCTCTGTCTGCCCTTCCAGGTT
3' ss Score
12.85
5' ss Seq
AAGGTCAGA
5' ss Score
6.8
Exon sequences
Seq C1 exon
TGGAGAATTTGTACACAGCCCTGCGGAACATCGACAGGAGTGAGATTGTTAACATGTTGGAGGGCTCCGGCAGGCAGAGCAGAAACCTCAAACCAGAGCGGAGACATGGGGACCGGGAGTACTCATTGTCACCCTCCCAGGTGAATG
Seq A exon
GTTACTCCTCGCTGCAGGACGAGCTGCTGTCCCCCGCCTCCCTGCAGTACGCTCTCCCCTCTCCACTGTGTGCAGACCAGTACTGGAACGAAGTGGCCGTCATAGACGCCATCCCCCTGGCGGCTACAGAGCATGACACCATGCTGGAGATGTCTGACATGCAGGTGTGGTCTGCGGGCCTCACACCCTCCCTGGTCACTGCTGAGGACTCCTCTCTGGAGTGCAGCAAGGCTGAGGACTCTGACGCCATACCAGAGTGGAAGTTGGAAGGGGCACACTCAGAGGACACGCAGGGCCCGGAGCTGGGCTCTCAGGACCTGGTGGAGGACGACACAGTGGATTCAGATGCCACAAATGGCCTGGCAGATTTGCTAGGTCAGGAGGAAG
Seq C2 exon
GCCAGCAGCGAGTTCACGCCCGAATCACAGACTCACCCTCAGTGAGGCAGGTGCTGGACAGAAGCCAGGCCAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSMUSG00000031543_MULTIEX1-2/2=C1-C2
Average complexity
C1*
Mappability confidence:
100%=100=100%
Protein Impact





	

	
Alternative protein isoforms (Ref)





No structure available

		

			
Features


			

				
Disorder rate (Iupred):
  C1=0.512 A=0.671 C2=0.758
 
                        

				
Domain overlap (PFAM):

					





						

							
C1:
PF0053117=Death=PD(27.4=46.0)

							
A:
NO

							
C2:
NO

						

					

				








    
Main Inclusion Isoform:
ENSMUSP00000133322





     
                   









    
Main Skipping Isoform:
ENSMUSP00000106316





     
      









    
Other Inclusion Isoforms:
ENSMUSP00000081050, ENSMUSP00000081051, ENSMUSP00000106313, ENSMUSP00000112850, ENSMUSP00000113495, ENSMUSP00000113531, ENSMUSP00000113571, ENSMUSP00000113656, ENSMUSP00000117966
          









    
Other Skipping Isoforms:
NA
  



Associated events







Other assemblies


mm10




Conservation


Human
(hg38)
chr8:41672354-41672912 
HIGH PSI
HsaEX0004114
(ANK1)
Human
(hg19)
chr8:41529872-41530430 
HIGH PSI
HsaEX0004114
(ANK1)
Rat
(rn6)
chr16:73690163-73690537 
ALTERNATIVE
RnoEX0009334
(Ank1)
Cow
(bosTau6)
chr27:36272646-36273035 
Chicken
(galGal4)
chr22:2617199-2617751 
HIGH PSI
GgaEX0004702
(chAnk1)
Chicken
(galGal3)
chr22:2667468-2668020 
HIGH PSI
GgaEX0004702
(Q90715_CHICK)
Zebrafish
(danRer10)
No conservation detected
Fruitfly
(dm6)
No conservation detected




Primers PCR

	

		

			
Suggestions for RT-PCR validation

			

				
F: 
AATTTGTACACAGCCCTGCGG

				
R: 
CTGGCCTGGCTTCTGTCCAG

				
Band lengths: 
215-602

			

		

	





	
Functional annotations
(Submit an annotation)

	


There are 1 annotated functions for this event 


PMID: 1388161
HsaEX0004114
Skipping (probably more as an ALTA) exhibits increased affinity for the cytoplasmic domain of the anion exchanger, spectrin, and tubulin.


		










GENOMIC CONTEXT[edit]












INCLUSION PATTERN[edit]






SPECIAL DATASETS
  • Pre-implantation embryo development
  • Neural differentiation time course
  • Muscular differentiation time course
  • Spermatogenesis cell types
  • Reprogramming of fibroblasts to iPSCs
  • Hematopoietic precursors and cell types






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