Special

MmuEX0006591 @ mm10

Exon Skipping

Gene
ENSMUSG00000099083 | Atf7
Description
activating transcription factor 7 [Source:MGI Symbol;Acc:MGI:2443472]
Coordinates
chr15:102547773-102553921:-
Coord C1 exon
chr15:102553784-102553921
Coord A exon
chr15:102551404-102551561
Coord C2 exon
chr15:102547773-102547872
Length
158 bp
Sequences
Splice sites
3' ss Seq
TTACTGTCTCCTCTTCCTAGGAA
3' ss Score
11.62
5' ss Seq
AGGGTAAGT
5' ss Score
10.45
Exon sequences
Seq C1 exon
GGTGCTGCTGGGCCTCTTGACATGTCTCTGCCTTCTACACCAGACATCAAAATCAAGGAAGAAGAGCCAGTGGAAGTAGACTCATCGCCCCCTGACAGTCCTGCTTCTAGCCCCTGTTCCCCACCACTGAAGGAGAAG
Seq A exon
GAAGTTACCACAAAACCGGTTGTGATCTCTACCCCTACACCTACCATTGTACGTCCTGGCTCCCTGCCTCTCCACTTAGGTTATGATCCACTTCATCCAACTCTTCCTTCCCCAACCTCTGTCATCACACAGGCTCCACCATCCAACAGGCAAATAGG
Seq C2 exon
ATCTCCTACTGGCTCCCTCCCTCTCGTCATGCATCTTGCTAATGGACAGACCATGCCTATGTTGCCAGGGCCTCCAGTACAGATGCCTTCTGTTATTTCG
VastDB Features
Vast-tools module Information
Secondary ID
ENSMUSG00000099083_CASSETTE3
Average complexity
S
Mappability confidence:
100%=100=100%
Protein Impact





	

	
ORF disruption upon sequence exclusion





No structure available

		

			
Features


			

				
Disorder rate (Iupred):
  C1=0.985 A=0.982 C2=1.000
 
                        

				
Domain overlap (PFAM):

					





						

							
C1:
NO

							
A:
NO

							
C2:
NO

						

					

				








    
Main Inclusion Isoform:
ENSMUSP00000139181





     
                   









    
Main Skipping Isoform:
NA





     
      









    
Other Inclusion Isoforms:
ENSMUSP00000104456, ENSMUSP00000130130, ENSMUSP00000139054, ENSMUSP00000139217, ENSMUSP00000139243, ENSMUSP00000139308, ENSMUSP00000139379
          









    
Other Skipping Isoforms:
NA
  



Associated events






Other assemblies


mm9




Conservation


Human
(hg38)
chr12:53534502-53534659 
HIGH PSI
HsaEX0006517
(ATF7)
Human
(hg19)
chr12:53928286-53928443 
HIGH PSI
HsaEX0006517
(ATF7)
Rat
(rn6)
chr7:144149037-144149194 
HIGH PSI
RnoEX0012557
(Atf7)
Cow
(bosTau6)
chr5:26659222-26659379 
HIGH PSI
BtaEX6020300
(ATF7)
Chicken
(galGal4)
chrUn_JH376268:12043-12200 
Chicken
(galGal3)
chrUn_random:38349549-38349580 
HIGH PSI
GgaEX6047969
(ATF7)
Zebrafish
(danRer10)
chr23:27531968-27532125 
HIGH PSI
DreEX6081106
(atf7a)
Fruitfly
(dm6)
No conservation detected




Primers PCR

	

		

			
Suggestions for RT-PCR validation

			

				
F: 
GTGCTGCTGGGCCTCTTG

				
R: 
GAAGGCATCTGTACTGGAGGC

				
Band lengths: 
227-385

			

		

	





	
Functional annotations
(Submit an annotation)

	


There are 2 annotated functions for this event 


PMID: 25301550
HsaEX0006517
Encodes an experimentally validated Eukaryotic Linear Motif (ELM). Method: two hybrid. ELM ID: ELMI003062; ELM sequence: RPGSLPL; Overlap: FULL


PMID: 26538579
HsaEX0006517
Encodes an experimentally validated Eukaryotic Linear Motif (ELM). Method: fluorescence polarization spectroscopy, protein array. ELM ID: ELMI003062; ELM sequence: RPGSLPL; Overlap: FULL


		










GENOMIC CONTEXT[edit]












INCLUSION PATTERN[edit]






SPECIAL DATASETS
  • Pre-implantation embryo development
  • Ribosome-engaged transcriptomes of neuronal types
  • Neural differentiation time course
  • Muscular differentiation time course
  • Spermatogenesis cell types
  • Reprogramming of fibroblasts to iPSCs
  • Hematopoietic precursors and cell types





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